Identitets-, Byggelinie- og Servitutattest

En Identitet-, Byggelinie- og Servitutattest er en attest, som anvendes til at atteste-re for et byggeris lovlige placering. Attesten knytter sig til et behov og der gives ingen retningslinjer i nogen lov, der præciserer, hvordan attesten skal udarbejdes. Attesten har i praksis opnået en grad af udbredelse, der gør, at det synes væsentligt at undersøge, hvorledes attestens anvendelse og indhold forholder sig til lan-dinspektørens professionelle ansvar. Derfor valgte en specialegruppe på Aalborg Universitet i foråret 2017 at undersøge emnet og denne artikel er blevet til i et efterfølgende samarbejde mel-lem specialegruppen og Aalborg Universitet med henblik på at formidle resultaterne. Undersøgelsen blev bygget op omkring den juridiske metode, hvilket afspejles i artiklen, der på denne ene side undersøger praksis og på den anden side reglen

Polycystic ovary syndrome and hyperglycaemia in pregnancy. A narrative review and results from a prospective Danish cohort study

Insulin resistance is common in polycystic ovary syndrome (PCOS). PCOS may be associated with increased risk of gestational diabetes mellitus (GDM).To 1) review literature regarding PCOS and hyperglycaemia in pregnancy and 2) present original data from Odense Child Cohort (OCC) regarding GDM in PCOS.Literature search including original studies from 2000-18. OCC included 2,548 pregnant women, 9.5 % (n=241) had PCOS. Fasting plasma glucose was measured in 1,519 and 659 oral glucose tolerance tests were performed (with risk factor for GDM, n= 384, without risk factors, n=275), applying two different GDM criteria RESULTS: 30 studies were eligible using 12 different sets of diagnostic criteria for GDM. Ten studies included n > 50, control group, assessment of GDM and BMI. Results were not uniform, but supported that higher BMI, higher age, Asian ethnicity, and fertility treatment increased the risk of GDM in PCOS. In OCC, women with PCOS and controls had similar prevalences of GDM independent of different sets of criteria for GDM.PCOS may not be an individual risk factor for GDM. Pregnancies in PCOS are characterized by factors known to increase risk of GDM, especially high BMI and fertility treatment

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Glucagon is secreted from pancreatic a cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in b cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion