51 research outputs found
Greenland and Canadian Arctic ice temperature profiles database
Here, we present a compilation of 95 ice temperature profiles from 85 boreholes from the Greenland ice sheet and peripheral ice caps, as well as local ice caps in the Canadian Arctic. Profiles from only 31 boreholes (36â%) were previously available in open-access data repositories. The remaining 54 borehole profiles (64â%) are being made digitally available here for the first time. These newly available profiles, which are associated with pre-2010 boreholes, have been submitted by community members or digitized from published graphics and/or data tables. All 95 profiles are now made available in both absolute (meters) and normalized (0 to 1 ice thickness) depth scales and are accompanied by extensive metadata. These metadata include a transparent description of data provenance. The ice temperature profiles span 70Â years, with the earliest profile being from 1950 at Camp VI, West Greenland. To highlight the value of this database in evaluating ice flow simulations, we compare the ice temperature profiles from the Greenland ice sheet with an ice flow simulation by the Parallel Ice Sheet Model (PISM). We find a cold bias in modeled near-surface ice temperatures within the ablation area, a warm bias in modeled basal ice temperatures at inland cold-bedded sites, and an apparent underestimation of deformational heating in high-strain settings. These biases provide process level insight on simulated ice temperatures
Rhinitis associated with asthma is distinct from rhinitis alone: TARIAâMeDALL hypothesis
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of âone-airway-one-disease,â coined over 20âyears ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the âEpithelial Barrier Hypothesis.â This review determined that the âone-airway-one-diseaseâ concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme âallergicâ (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio
ARDD 2020: from aging mechanisms to interventions
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA
Optimering af bygningers energibehov, indeklima og robusthed ved brug af generiske rumtype og Machine Learning
Early Holocene sea-level changes in Ăresund, southern Scandinavia
The Baltic Sea and Kattegat are connected via three straits: StorebĂŠlt, LillebĂŠlt and Ăresund (Fig. 1). Ăresund is the shallowest with a threshold around 7 m deep and increasing water depths to the north (Fig. 2). In the early Holocene, global sea-level rise led to reflooding of Ăresund. It started in northern Ăresund which was transformed into a fjord. However, so far the timing of the transgression has not been well determined, but sediment cores collected north of the threshold, at water depths of 12 to 20 m, and a new series of radiocarbon ages help to constrain this. As the relative sea level continued to rise, the threshold in Ăresund was also flooded, and Ăresund became a strait. In mid-Holocene time, the relative sea level rose until it was 4â5 m higher than at present, and low-lying areas around Ăresund became small fjords. During the late Holocene, the relative sea level fell again. Part of the data set discussed here was presented by Andreasen (2005)
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