310 research outputs found

    Investigating the Body in the Victorian Asylum

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    This book explores how the body was investigated in the late nineteenth-century asylum in Britain. As more and more Victorian asylum doctors looked to the bodily fabric to reveal the ‘truth’ of mental disease, a whole host of techniques and technologies were brought to bear upon the patient's body. These practices encompassed the clinical and the pathological, from testing the patient's reflexes to dissecting the brain. Investigating the Body in the Victorian Asylum takes a unique approach to the topic, conducting a chapter-by-chapter dissection of the body. It considers how asylum doctors viewed and investigated the skin, muscles, bones, brain, and bodily fluids. The book demonstrates the importance of the body in nineteenth-century psychiatry as well as how the asylum functioned as a site of research, and will be of value to historians of psychiatry, the body, and scientific practice

    Investigating the Body in the Victorian Asylum: Doctors, Patients, and Practices

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    This book explores how the body was investigated in the late nineteenth-century asylum in Britain. As more and more Victorian asylum doctors looked to the bodily fabric to reveal the ‘truth’ of mental disease, a whole host of techniques and technologies were brought to bear upon the patient's body. These practices encompassed the clinical and the pathological, from testing the patient's reflexes to dissecting the brain. Investigating the Body in the Victorian Asylum takes a unique approach to the topic, conducting a chapter-by-chapter dissection of the body. It considers how asylum doctors viewed and investigated the skin, muscles, bones, brain, and bodily fluids. The book demonstrates the importance of the body in nineteenth-century psychiatry as well as how the asylum functioned as a site of research, and will be of value to historians of psychiatry, the body, and scientific practice

    A demographic study of adolescent in-patients at Lentegeur Psychiatric Hospital 1986-1990 : implications for policy and intervention

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    Bibliography: pages 108-115.The aim of the proposed study is to evaluate demographic factors and treatment characteristics contained in the historical records of those treated as in-patients at the Sonstraal Adolescent unit of Lentegeur Hospital, during the period 1986 to 1990. This demographic study details the following aspects of the adolescent in-patients: size, that is, numbers of those admitted to the unit; composition, including age, sex and area. Treatment characteristics such as reasons for admission, diagnosis of psychopathology, referral agent on admission and discharge and length of stay in the unit are considered. The data for the study have been extracted from the clinical records contained at Sonstraal, namely , the 'Clinical Summary on Discharge' form. This form is completed by the therapist of each adolescent attending the unit. The EpiInfo computer programmes have been utilised to create a database and to select the appropriate procedures and statistics which form the basis for data analysis and interpretation. Data interpretation includes an analysis of the emerging trends and details the implications for policy issues, unit staffing and treatment options. Analysis of the trends and comparisons with literature findings have facilitated the generation of hypotheses which could be tested in future studies. This study therefore provides a working document for future prioritising and planning of in-patient, out-patient and community mental health services to adolescents, their families and communities. This involves recommendations for intervention and community involvement. In addition, the study provides a basis for future research into adolescent mental health care

    Contrasting the effectiveness and efficiency of virtual reality and real environments in the treatment of acrophobia

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    Previous studies reported good results in using virtual reality for the treatment of acrophobia. Similarly this paper reports the use of a virtual environment for the treatment of acrophobia. In the study, 10 subjects were exposed to three sessions of simulated heights in a virtual reality (VR) system, and 5 others were exposed to a real environment. Both groups revealed significant progress in a range of anxiety, avoidance and behaviour measurements when confronted with virtual as well as real height circumstances. Despite VR participants experiencing considerably shorter treatment times than the real-world subjects, significant improvements were recorded on the Behavioural Avoidance Test, the Attitudes Toward Heights Questionnaire and the Acrophobia Questionnaire. These results are suggestive of a possible higher effectiveness and efficiency of VR in treating acrophobia

    Predicting the efficacy of simulator-based training using a perceptual judgment task versus questionnaire-based measures of presence

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    The quality of a virtual environment, as characterized by factors such as presence and fidelity, is of interest to developers and users of simulators for many reasons, not least because both factors have been linked to improved outcomes in training as well as a reduced incidence of simulator sickness. Until recently, most approaches to measuring these factors have been based on subjective, postexposure questioning. This approach has, however, been criticized because of the shortcomings of self-report and the need to delay feedback or interrupt activity. To combat these problems, recent papers on the topic have proposed the use of behavioral measures to assess simulators and predict training outcomes. Following their lead, this paper makes use of a simple perceptual task in which users are asked to estimate their simulated speed within the environment. A longitudinal study of training outcomes using two of the simulators revealed systematic differences in task performance that matched differences measured using the perceptual task in a separate group of control subjects. A separate analysis of two standard presence questionnaires revealed that they were able to predict learning outcomes on a per individual basis, but that they were insensitive to the differences between the two simulators. The paper concludes by explaining how behavioral measures of the type proposed here can complement questionnaire-based studies, helping to motivate design aspects of new simulators, prompting changes to existing systems, and constraining training scenarios to maximize their efficacy

    Synthesis of fluorescent phosphorus ligands and their applications in medical imaging and catalysis

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    Eng. D. ThesisThis thesis reports the synthesis of novel, air-stable, fluorescent phosphorus-containing compounds, based on a Bodipy backbone, and their applications in cell imaging and catalysis. The syntheses of all the novel target compounds reported in this thesis are via a primary phosphine, an under-utilised class of compound due to a hazardous reputation. Chapter 1 explores the stability of primary phosphines, how they can be made user-friendly and the ability to create a library of novel phosphorus compounds via the phosphorus-hydrogen bonds. The LJH group synthesised the first, air-stable, fluorescent primary phosphine and Chapter 2 explores a second generation of this type of ligand with an increased fluorescent quantum yield due to the addition of alkyne groups on the boron atom. Chapter 3 details the coordination chemistry of primary phosphines to group 6 and 8 transition metals. Interestingly, the addition of the metals had different effects on the photophysical properties, group 6 metal complexes retained high quantum yields, whereas group 8 metals quenched the fluorescence, possibly due to the heavy atom effect. Chapter 4 discusses the synthesis of fluorescent phosphonium salts which have the potential to be used as trifunctional imaging agents. The three functions within the compounds include i) a fluorophore, to provide in vitro fluorescence imaging, ii) a positive charge on the phosphorus atom to introduce organelle specificity – in this case, to the mitochondria and iii) the inclusion of an 18F radioisotope enables in vivo imaging techniques such as PET imaging. Chapter 5 shows further versatility of fluorescent primary phosphines where we report the synthesis of a novel, chiral, fluorescent phosphonite ligand that has been tested for its applications as a catalyst in asymmetric hydrogenation reactions of a benchmark substrate. The results showed full conversion and an enantiomeric excess (ee) of >99%. The final chapter discusses the importance of the aryl linker between the Bodipy core and the phosphorus atom. The compounds synthesised in this chapter show decreased fluorescence when the phosphorus atom is directly bound to the fluorophore and have potential applications as a switch.EPSRC for funding, as well as High Force Research who were my industrial sponsor

    A list of balanced incomplete block designs for r \u3c 30

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    A balanced incomplete block design consists of a set of v elements arranged into b k-element subsets called blocks such that each element occurs r times and each pair of elements appears in lambda distinct blocks. The numbers v,b,r,k,lambda are called the parameters of the design. A necessary condition that a design exist is that the parameters be integers satisfying: (1) vr = bk ( 2) r(k-1) = lambda (v-1

    Integer matrices obeying generalized incidence equations

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    Adolescent Healthcare Brokering: Prevalence, Experience, Impact, and Opportunities

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    BACKGROUND: Limited health literacy disproportionately affects those with limited English proficiency (LEP). Parents with LEP might rely on their adolescent children to interpret health information. We call this adolescent health care brokering. This study uncovers the prevalence of brokering, kinds of tasks, emotional and academic impact, and desired support. METHODS: We invited 165 students from health classes (in a community in which 29.8% are foreign-born and 53.4% speak another language at home) to complete a survey. We used IBM SPSS to calculate descriptive statistics. RESULTS: Of the 159 who received parental consent and assented, 54.1% (n=86) assist with healthcare tasks. When brokering, 80.2% (n=69) translate. Most common tasks were talking to a doctor, reading prescriptions, and searching on the Internet. Participants were most confident reading prescriptions and talking to a doctor and least confident finding healthcare services. Among brokers, 29.1% (n=24) missed school; 33.7% did not complete homework. They most wanted to learn about filling out insurance forms and talking to doctors. CONCLUSIONS: Despite assurances that children are not permitted to interpret, adolescents are acting as healthcare brokers. The impact can be academic and emotional. Findings indicate a need for further research and support for adolescents who want to learn about healthcare tasks
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