Early Childhood Special Education in a Refugee Resettlement Community: Challenges and Innovative Practices

There has been a significant increase in the number of children who are culturally and linguistically diverse (CLD) who qualify for early childhood special education (ECSE) services (Banerjee & Guiberson, 2012). The current study investigates the challenges and innovative practices in the evaluation and (ECSE) services for preschool aged children who are refugees. Twenty-eight early childhood educators who work in a small refugee resettlement community participated in a qualitative study using semi-structured interviews resulting in themes regarding challenges and innovative practices. Challenges include: lack of validated assessments, wait time for evaluations, different cultural perspectives and family advocacy. Innovative practices include: assessing skills not dependent on language and including caregivers in evaluations. Implications for future research and teacher preparation are discussed

Long Days Enhance Recognition Memory and Increase Insulin-like Growth Factor 2 in the Hippocampus

Light improves cognitive function in humans; however, the neurobiological mechanisms underlying positive effects of light remain unclear. One obstacle is that most rodent models have employed lighting conditions that cause cognitive deficits rather than improvements. Here we have developed a mouse model where light improves cognitive function, which provides insight into mechanisms underlying positive effects of light. To increase light exposure without eliminating daily rhythms, we exposed mice to either a standard photoperiod or a long day photoperiod. Long days enhanced long-term recognition memory, and this effect was abolished by loss of the photopigment melanopsin. Further, long days markedly altered hippocampal clock function and elevated transcription of Insulin-like Growth Factor2 (Igf2). Up-regulation of Igf2 occurred in tandem with suppression of its transcriptional repressor Wilm’s tumor1. Consistent with molecular de-repression of Igf2, IGF2 expression was increased in the hippocampus before and after memory training. Lastly, long days occluded IGF2-induced improvements in recognition memory. Collectively, these results suggest that light changes hippocampal clock function to alter memory, highlighting novel mechanisms that may contribute to the positive effects of light. Furthermore, this study provides insight into how the circadian clock can regulate hippocampus-dependent learning by controlling molecular processes required for memory consolidation

Seismic Coupling of Short-Period Wind Noise Through Mars’ Regolith for NASA’s InSight Lander

NASA’s InSight lander will deploy a tripod-mounted seismometer package onto the surface of Mars in late 2018. Mars is expected to have lower seismic activity than the Earth, so minimisation of environmental seismic noise will be critical for maximising observations of seismicity and scientific return from the mission. Therefore, the seismometers will be protected by a Wind and Thermal Shield (WTS), also mounted on a tripod. Nevertheless, wind impinging on the WTS will cause vibration noise, which will be transmitted to the seismometers through the regolith (soil). Here we use a 1:1-scale model of the seismometer and WTS, combined with field testing at two analogue sites in Iceland, to determine the transfer coefficient between the two tripods and quantify the proportion of WTS vibration noise transmitted through the regolith to the seismometers. The analogue sites had median grain sizes in the range 0.3–1.0 mm, surface densities of 1.3-1.8 gcm−3, and an effective regolith Young’s modulus of 2.5+1.9−1.4 MPa. At a seismic frequency of 5 Hz the measured transfer coefficients had values of 0.02–0.04 for the vertical component and 0.01–0.02 for the horizontal component. These values are 3–6 times lower than predicted by elastic theory and imply that at short periods the regolith displays significant anelastic behaviour. This will result in reduced short-period wind noise and increased signal-to-noise. We predict the noise induced by turbulent aerodynamic lift on the WTS at 5 Hz to be ∼2×10−10 ms−2 Hz−1/2 with a factor of 10 uncertainty. This is at least an order of magnitude lower than the InSight short-period seismometer noise floor of 10−8 ms−2 Hz−1/2

Intrapulmonary administration of recombinant activated factor VII in pediatric, adolescent, and young adult oncology and hematopoietic cell transplant patients with pulmonary hemorrhage

IntroductionDiffuse alveolar hemorrhage (DAH) is a devastating disease process with 50-100% mortality in oncology and hematopoietic cell transplant (HCT) recipients. High concentrations of tissue factors have been demonstrated in the alveolar wall in acute respiratory distress syndrome and DAH, along with elevated levels of tissue factor pathway inhibitors. Activated recombinant factor VII (rFVIIa) activates the tissue factor pathway, successfully overcoming the tissue factor pathway inhibitor (TFPI) inhibition of activation of Factor X. Intrapulmonary administration (IP) of rFVIIa in DAH is described in small case series with successful hemostasis and minimal complications.MethodsWe completed a single center retrospective descriptive study of treatment with rFVIIa and outcomes in pediatric oncology and HCT patients with pulmonary hemorrhage at a quaternary hematology/oncology hospital between 2011 and 2019. We aimed to assess the safety and survival of patients with pulmonary hemorrhage who received of IP rFVIIa.ResultsWe identified 31 patients with pulmonary hemorrhage requiring ICU care. Thirteen patients received intrapulmonary rFVIIa, while eighteen patients did not. Overall, 13 of 31 patients (41.9%) survived ICU discharge. ICU survival (n=6) amongst those in the IP rFVIIa group was 46.2% compared to 38.9% (n=7) in those who did not receive IP therapy (p=0.69). Hospital survival was 46.2% in the IP group and 27.8% in the non-IP group (p=0.45). There were no adverse events noted from use of IP FVIIa.ConclusionsIntrapulmonary rFVIIa can be safely administered in pediatric oncology patients with pulmonary hemorrhage and should be considered a viable treatment option for these patients

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Mu ̈ ller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss

A walking programme and a supervised exercise class versus usual physiotherapy for chronic low back pain: a single-blinded randomised controlled trial. (The Supervised Walking In comparison to Fitness Training for Back Pain (SWIFT) Trial)

BACKGROUND: Chronic low back pain (CLBP) is a persistent disabling condition with rising significant healthcare, social and economic costs. Current research supports the use of exercise-based treatment approaches that encourage people with CLBP to assume a physically active role in their recovery. While international clinical guidelines and systematic reviews for CLBP support supervised group exercise as an attractive first-line option for treating large numbers of CLBP patients at low cost, barriers to their delivery include space and time restrictions in healthcare settings and poor patient attendance. The European Clinical Guidelines have identified the need for research in the use of brief/minimal contact self-activation interventions that encourage participation in physical activity for CLBP. Walking may be an ideally suited form of individualized exercise prescription as it is easy to do, requires no special skills or facilities, and is achievable by virtually all ages with little risk of injury, but its effectiveness for LBP is unproven. METHODS AND DESIGN: This study will be an assessor-blinded randomized controlled trial that will investigate the difference in clinical effectiveness and costs of an individualized walking programme and a supervised general exercise programme compared to usual physiotherapy, which will act as the control group, in people with chronic low back pain. A sample of 246 patients will be recruited in Dublin, Ireland through acute general hospital outpatient physiotherapy departments that provide treatment for people with CLBP. Patients will be randomly allocated to one of the three groups in a concealed manner. The main outcomes will be functional disability, pain, quality of life, fear avoidance, back beliefs, physical activity, satisfaction and costs, which will be evaluated at baseline, and 3, 6 and 12 months [follow-up by pre-paid postage]. Qualitative telephone interviews and focus groups will be embedded in the research design to obtain feedback about participants' experiences of the interventions and trial participation, and to inform interpretation of the quantitative data. Planned analysis will be by intention to treat (quantitative data) and thematic analysis (qualitative data) DISCUSSION: The trial will evaluate the effectiveness of a walking programme and a supervised general exercise programme compared to usual physiotherapy in people with CLBP. TRIAL REGISTRATION: Current controlled trial ISRCTN1759209

SDSS J124602.54+011318.8: A Highly Luminous Optical Transient at z=0.385

We report the discovery of a highly luminous optical transient (OT), SDSS J124602.54+011318.8, associated with a galaxy at a redshift of 0.385. In this paper we consider the possibility that the OT may be a GRB afterglow. Three sets of images and two sets of spectra were obtained as part of the normal operations of the Sloan Digital Sky Survey (SDSS). In the first two image sets, observed two nights apart, the object appears as a point source at $r^{*}\approx 17$. The third image set, observed about 410 days later, shows an extended source which is more than 2.5 magnitudes fainter. The spectra were observed about 400 and 670 days after the first two image sets, and both show an apparently normal galaxy at a redshift of 0.385. Associating the OT with the galaxy, the absolute magnitude was $M_{r^*}=-24.8$, which is over 4 magnitudes brighter than the most luminous supernova ever measured. The spectral energy distributions of the galaxy-subtracted OT derived from the first two image sets are well-fit by single power-laws with indices of $\beta_{\nu}=-0.92$ and -1.29 respectively, similar to most GRB afterglows. Based upon the luminosity of the OT, non-detections in contemporaneous ROTSE-I images, and the change in spectral slope, the OT, if an afterglow, was likely discovered early during a ``plateau'' or slowly-fading phase. The discovery of a GRB afterglow at this stage of the SDSS is consistent with expectations, but only if the optical emission is much less strongly beamed than the gamma-rays. We emphasize that other explanations for the OT cannot be ruled out; a recent follow-up study by [galyam02] provides strong evidence that this source is in fact an unusual AGN.Comment: Updated version to appear in Ap