Trajectories of the Effects of Sad Mood Induction Procedures (MIPs)

Mood Induction Procedures (MIPs) are used widely in cognitive vulnerability to depression research. Although research supports certain MIPs as effective, little research has validated the assumption that MIP-induced sad moods are sufficiently persistent. This study addressed three questions: How long does an MIP-induced mood last? What are the shapes of the trajectories of the mood effects? Do these trajectories differ by type of MIP? Four-hundred-and-one undergraduate students were randomly assigned to undergo one of three commonly used sad MIPs or a neutral MIP. Mood was repeatedly measured immediately prior to and following the MIP.Results did not support the widely held belief that commonly used MIPs induce a sufficient and persistent sad mood. Current theories of cognitive vulnerability may therefore be biased by empirical findings predicated on such assumptions. This study has profound implications for the validity of current conceptualizations of depression and recommendations for the treatment of this disorder

A Framework for Creating a Campus Culture of Compassion: A Participatory Action Research Approach to Equality

The presence of students with disabilities on university campuses is steadily increasing; however, their total integration and inclusion into campus life has not been as successful (Merchant & Gajar, 1997; Promis, et al., 2001). Canadian students with disabilities continue to be marginalized within universities, mainly because a framework for inclusion has not been firmly established (Promis et al., 2001). Although universities offer services to support academic success, other facets of campus life offered to the general student population, such as recreation or athletics, are often neglected for students with disabilities. These aspects of student life should not be considered trivial as they have many benefits and can enhance a person’s experiences and quality of life at university (Ashton-Shaeffer et al., 2001; Blinde & McLung, 1997; Blinde & Taub, 1999; Promis et al., 2001). Guided by critical disability theory and the concept of embodiment, this dissertation used a participatory action research approach that united key partners from the University of Guelph community in order to examine issues around accessibility and inclusion of students with disabilities in campus recreational and athletic opportunities. The team included representatives from the University’s Centre for Students with Disabilities and the Department of Athletics, an undergraduate student with a disability, and two university alumni. The ultimate goal was to develop a planning framework to guide universities in supporting the human rights and inclusion of students with disabilities in extra-curricular campus life. Interviews were conducted with five research team members and 18 University of Guelph stakeholders, including: students with and without disabilities, staff members from the Department of Athletics and the Centre for Students with Disabilities, faculty members, and senior administrators. A focus group was also held to share findings and generate feedback on a preliminary draft of the framework. What emerged from data analysis of the interviews, the focus group, team meetings, and journal entries was the development of a framework for Creating a Campus Culture of Compassion. This framework identifies how universities can implement programs, policies, services and practices that better respond to the changing and diverse needs and interests of students with disabilities in order to ensure their full engagement in all areas of campus life. The framework centres around six guiding principles that help guide universities toward developing a campus culture that is compassionate. Essentially, a campus culture of compassion values: (a) access for all; (b) diversity and uniqueness; (c) interdependence and social responsibility; (d) diverse knowledge basis, voices, and perspectives; (e) the power of learning and education as a tool for social change; and (f) the whole person. The framework also indicates three fundamental characteristics that a campus culture of compassion must possess. In essence, post-secondary institutions and their community members must be: (a) interconnected, (b) supportive and enabling, and (c) informed. Six process pieces are included in the framework which enables a campus culture of compassionate to be fuelled and sustained over time. These pieces include: (a) creating a vision for the future, (b) constructing a plan to achieve the vision, (c) securing funds to put the plan in place, (d) thinking critically and measuring actions against the vision, (e) being proactive to make change happen, and (f) reaching beyond compliance. The framework encourages university stakeholders to collectively reflect, dialogue, and collaborate in order to create broader systemic changes. These changes are necessary since constraints to campus engagement can threaten a student’s well-being and sense of self. This framework can serve as a starting point to initiate these conversations and inspire universities to use a participatory approach to encourage positive social change within the university context

How long do mood induction procedure (MIP) primes really last? Implications for cognitive vulnerability research.

BACKGROUND: Mood Induction Procedures (MIPs) are used widely in research on cognitive vulnerability to depression. Although empirical evidence supports certain MIPs as effective, little research has evaluated whether MIP-induced sad moods are sufficiently persistent. This study aimed to determine (1) how long an MIP-induced mood lasts according to commonly used operational definitions and (2) whether these findings vary according to the type of MIP used. METHODS: Four-hundred-and-one undergraduate students were randomly assigned to one of three commonly used sad MIPs (music, memory, music+memory) or to one of three matched neutral MIPs. Mood was repeatedly measured immediately prior to and following the MIP. RESULTS: Results did not support the widely held belief that commonly used MIPs induce a sufficient and persistent sad mood. The memory-related MIPs induced the most persistent sad mood. Based on the majority of operational definitions, however, induced mood effects did not last longer than 4 min, regardless of MIP type. LIMITATIONS: Future studies should examine additional factors that may have affected the trajectories observed in the current study (e.g., task completed in between mood measurements) and in vulnerable (e.g., past-depressed) populations. CONCLUSIONS: This study constitutes an important first step in validating the use of MIPs in cognitive vulnerability research and provides researchers with important information on future study designs. More important, the study raises doubt about the validity of various conclusions drawn from some MIP studies and calls into question the theoretical conceptualizations of depression that are based on potentially biased results and a possibly incomplete literature

Using a behavioural approach to explore the factors that affect questionnaire return within a clinical trial : a qualitative study based on the Theoretical Domains Framework

Funding This research is funded by the Chief Scientist Office of the Scottish Government’s Health and Social Care Department (HIPS/16/46). KG held a Medical Research Council UK Methodology Fellowship during the delivery of this project (MR/L01193X/1). The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. The funders had no involvement in study design, collection, analysis and interpretation of data, reporting or the decision to publish. in a recent paper. Acknowledgements The authors would like to thank the patients for volunteering their time to participate in this study and to Rebecca Bruce and Karen Innes for facilitating recruitment.Peer reviewedPublisher PD

A systematic review of economic analyses of psychological interventions and therapies in health-related settings

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Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital : a multicentre randomised controlled trial

Copyright © 2012 Elsevier Ltd. All rights reserved. PMID: 23134837 [PubMed - indexed for MEDLINE]Peer reviewedPostprin

The Infrared Imaging Spectrograph (IRIS) for TMT: Data Reduction System

IRIS (InfraRed Imaging Spectrograph) is the diffraction-limited first light instrument for the Thirty Meter Telescope (TMT) that consists of a near-infrared (0.84 to 2.4 $\mu$m) imager and integral field spectrograph (IFS). The IFS makes use of a lenslet array and slicer for spatial sampling, which will be able to operate in 100's of different modes, including a combination of four plate scales from 4 milliarcseconds (mas) to 50 mas with a large range of filters and gratings. The imager will have a field of view of 34$\times$34 arcsec$^{2}$ with a plate scale of 4 mas with many selectable filters. We present the preliminary design of the data reduction system (DRS) for IRIS that need to address all of these observing modes. Reduction of IRIS data will have unique challenges since it will provide real-time reduction and analysis of the imaging and spectroscopic data during observational sequences, as well as advanced post-processing algorithms. The DRS will support three basic modes of operation of IRIS; reducing data from the imager, the lenslet IFS, and slicer IFS. The DRS will be written in Python, making use of open-source astronomical packages available. In addition to real-time data reduction, the DRS will utilize real-time visualization tools, providing astronomers with up-to-date evaluation of the target acquisition and data quality. The quicklook suite will include visualization tools for 1D, 2D, and 3D raw and reduced images. We discuss the overall requirements of the DRS and visualization tools, as well as necessary calibration data to achieve optimal data quality in order to exploit science cases across all cosmic distance scales.Comment: 13 pages, 2 figures, 6 tables, Proceeding 9913-165 of the SPIE Astronomical Telescopes + Instrumentation 201

Assessing the accuracy of a large observational registry of neovascular age-related macular degeneration

PURPOSE To evaluate the accuracy of an observational database that tracks real-world treatment outcomes for neovascular age-related macular degeneration. METHODS We audited 245 randomly sampled eyes from 189 patients with 3,356 visits from 11 doctors in the Fight Retinal Blindness! DATABASE Sex, birth year, previous treatments received, treatment, and visual acuity were validated against the clinical notes. Error rates, the proportion of missed visits (the number of visits present in the patient record but not entered into Fight Retinal Blindness!), the level of agreement using Cohen's kappa (κ) and intraclass correlation coefficients, and positive and negative predictive values were calculated. A visual acuity error was defined as an absolute difference of ≥5 letters. RESULTS The overall error rate was 3.5% (95% confidence interval: 3.1-3.9). The error rate for visual acuity was 5.1% (95% confidence interval: 4.2-5.9) and <5% for the remaining fields. The level of agreement for each field ranged from good to excellent (κ or intraclass correlation ≥ 0.75). The positive predictive value and negative predictive value for visits were 99% and 89%, respectively. The proportion of missed visits was 10.2%. CONCLUSION Accuracy of the Fight Retinal Blindness! database was good (>95%). The rate of missed visits was high, possibly due to the high burden of retrospective data entry or patients switching practitioners during treatment

Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells

Extent: 13p.Background: Walnuts significantly decrease total and low-density lipoprotein cholesterol in normo- and hypercholesterolemic individuals. No study to date has evaluated the effects of walnuts on cholesterol efflux, the initial step in reverse cholesterol transport, in macrophage-derived foam cells (MDFC). The present study was conducted to investigate the mechanisms by which walnut oil affects cholesterol efflux. Methods: The extract of English walnuts (walnut oil) was dissolved in DMSO and applied to cultured THP-1 MDFC cells (0.5 mg/mL). THP-1 MDFC also were treated with human sera (10%, v:v) taken from subjects in a walnut feeding study. Cholesterol efflux was examined by liquid scintillation counting. Changes in gene expression were quantified by real time PCR. Results: Walnut oil treatment significantly increased cholesterol efflux through decreasing the expression of the lipogenic enzyme stearoyl CoA desaturase 1 (SCD1) in MDFC. Alpha-linolenic acid (ALA), the major n-3 polyunsaturated fatty acids found in walnuts, recaptured SCD1 reduction in MDFC, a mechanism mediated through activation of nuclear receptor farnesoid-X-receptor (FXR). Postprandial serum treatment also increased cholesterol efflux in MDFC. When categorized by baseline C-reactive protein (CRP; cut point of 2 mg/L), subjects in the lower CRP sub-group benefited more from dietary intervention, including a more increase in cholesterol efflux, a greater reduction in SCD1, and a blunted postprandial lipemia. Conclusion: In conclusion, walnut oil contains bioactive molecules that significantly improve cholesterol efflux in MDFC. However, the beneficial effects of walnut intake may be reduced by the presence of a pro-inflammatory state.Jun Zhang, Jessica A Grieger, Penny M Kris-Etherton, Jerry T Thompson, Peter J Gillies, Jennifer A Fleming and John P Vanden Heuve