3,506 research outputs found
Oesophageal pressure-flow metrics in relation to bolus volume, bolus consistency and bolus perception
Author version made available in accordance with the publisher's policy.The utility of combined oesophageal pressure–impedance recording has been enhanced by automation of data analysis.
To understand how oesophageal function as measured by automated impedance manometry (AIM) pressure-flow analysis varies with bolus characteristics and subjective perception of bolus passage.
Oesophageal pressure–impedance recordings of 5 and 10 ml liquid or viscous swallows and 2 and 4 cm solid swallows from 20 healthy control subjects (five male; 25–73 years) were analysed. Metrics indicative of bolus pressurization (intrabolus pressure and intrabolus pressure slope) were derived. Bolus flow resistance, the relationship between bolus pressurization and flow timing, was assessed using a pressure-flow index. Bolus retention was assessed using the ratio of nadir impedance to peak pressure impedance (impedance ratio). Subjective perception of bolus passage was assessed swallow by swallow.
Viscosity increased the bolus flow resistance and reduced bolus clearance. Responses to boluses of larger volume and more viscous consistency revealed a positive correlation between bolus pressurization and oesophageal peak pressure. Flow resistance was higher in subjects who perceived bolus hold up of solids.
Bolus volume and bolus type alter oesophageal function and impact AIM analysis metrics descriptive of oesophageal function. Perception of bolus transit was associated with heightened bolus pressurization relative to bolus flow
The Luminosities of Protostars in the Spitzer c2d and Gould Belt Legacy Clouds
Motivated by the long-standing "luminosity problem" in low-mass star
formation whereby protostars are underluminous compared to theoretical
expectations, we identify 230 protostars in 18 molecular clouds observed by two
Spitzer Space Telescope Legacy surveys of nearby star-forming regions. We
compile complete spectral energy distributions, calculate Lbol for each source,
and study the protostellar luminosity distribution. This distribution extends
over three orders of magnitude, from 0.01 Lsun - 69 Lsun, and has a mean and
median of 4.3 Lsun and 1.3 Lsun, respectively. The distributions are very
similar for Class 0 and Class I sources except for an excess of low luminosity
(Lbol < 0.5 Lsun) Class I sources compared to Class 0. 100 out of the 230
protostars (43%) lack any available data in the far-infrared and submillimeter
(70 um < wavelength < 850 um) and have Lbol underestimated by factors of 2.5 on
average, and up to factors of 8-10 in extreme cases. Correcting these
underestimates for each source individually once additional data becomes
available will likely increase both the mean and median of the sample by 35% -
40%. We discuss and compare our results to several recent theoretical studies
of protostellar luminosities and show that our new results do not invalidate
the conclusions of any of these studies. As these studies demonstrate that
there is more than one plausible accretion scenario that can match
observations, future attention is clearly needed. The better statistics
provided by our increased dataset should aid such future work.Comment: Accepted for publication in AJ. 21 pages, 10 figures, 4 table
Young Stellar Objects in the Gould Belt
We present the full catalog of Young Stellar Objects (YSOs) identified in the
18 molecular clouds surveyed by the Spitzer Space Telescope "cores to disks"
(c2d) and "Gould Belt" (GB) Legacy surveys. Using standard techniques developed
by the c2d project, we identify 3239 candidate YSOs in the 18 clouds, 2966 of
which survive visual inspection and form our final catalog of YSOs in the Gould
Belt. We compile extinction corrected SEDs for all 2966 YSOs and calculate and
tabulate the infrared spectral index, bolometric luminosity, and bolometric
temperature for each object. We find that 326 (11%), 210 (7%), 1248 (42%), and
1182 (40%) are classified as Class 0+I, Flat-spectrum, Class II, and Class III,
respectively, and show that the Class III sample suffers from an overall
contamination rate by background AGB stars between 25% and 90%. Adopting
standard assumptions, we derive durations of 0.40-0.78 Myr for Class 0+I YSOs
and 0.26-0.50 Myr for Flat-spectrum YSOs, where the ranges encompass
uncertainties in the adopted assumptions. Including information from
(sub)millimeter wavelengths, one-third of the Class 0+I sample is classified as
Class 0, leading to durations of 0.13-0.26 Myr (Class 0) and 0.27-0.52 Myr
(Class I). We revisit infrared color-color diagrams used in the literature to
classify YSOs and propose minor revisions to classification boundaries in these
diagrams. Finally, we show that the bolometric temperature is a poor
discriminator between Class II and Class III YSOs.Comment: Accepted for publication in ApJS. 29 pages, 11 figures, 14 tables, 4
appendices. Full versions of data tables (to be published in machine-readable
format by ApJS) available at the end of the latex source cod
The Multiplicity of M-Dwarfs in Young Moving Groups
We image 104 newly identified low-mass (mostly M-dwarf) pre-main sequence
members of nearby young moving groups with Magellan Adaptive Optics (MagAO) and
identify 27 binaries with instantaneous projected separation as small as 40
mas. 15 were previously unknown. The total number of multiple systems in this
sample including spectroscopic and visual binaries from the literature is 36,
giving a raw multiplicity rate of at least for this
population. In the separation range of roughly 1 - 300 AU in which infrared AO
imaging is most sensitive, the raw multiplicity rate is at least
for binaries resolved by the MagAO infrared camera (Clio). The
M-star sub-sample of 87 stars yields a raw multiplicity of at least
over all separations, for secondary
companions resolved by Clio from 1 to 300 AU ( for all known
binaries in this separation range). A combined analysis with binaries
discovered by the Search for Associations Containing Young stars shows that
multiplicity fraction as a function of mass and age over the range of 0.2 to
1.2 and 10 - 200 Myr appears to be linearly flat in both parameters
and across YMGs. This suggests that multiplicity rates are largely set by 100
Myr without appreciable evolution thereafter. After bias corrections are
applied, the multiplicity fraction of low-mass YMG members () is
in excess of the field.Comment: 25 page
Helium-isotope constraints on palaeoceanographic change and sedimentation rates during precession cycles (Cenomanian Scaglia Bianca Formation, central Italy)
For much of the pelagic sedimentary record, time control is limited to the resolution of precession cycles (ca 20 kyr): the Milankovitch parameter that forms the most detailed metronome for the Cenozoic and Mesozoic Eras. The influence of precession is often detected in lithological alternations, where the duration represented by individual lithologies is not well constrained. Here the novel technique of extraterrestrial helium abundance (3HeET) is used to investigate the sedimentation dynamics and palaeoceanography within individual precessional cycles. High-resolution 3HeET timescales were produced for four precession cycles from the rhythmically bedded Scaglia Bianca Formation, a sequence of Upper Cretaceous (Cenomanian) deep-marine pelagic limestones from central Italy that are well characterized by cyclostratigraphy. Using 3HeET concentrations as a proxy for sedimentation rate allows instantaneous sedimentation rates and organic-carbon mass accumulation rates to be calculated for each bed within a precession cycle. Eccentricity is known to modulate the amplitude of precession forcing, and precession cycles deposited under eccentricity maxima and minima were selected for comparison. Lithological changes through these chert–(black shale)–limestone cycles are explained using the concept of ‘palaeoenvironmental thresholds’; these timescale calculations indicate that when the amplitude of precessional insolation forcing was greatest (at eccentricity maxima) the palaeoenvironmental system spent longer in the more nutrient-rich environment under which siliceous and organic-rich sediments were deposited, reflecting increased time spent above a ‘threshold’ insolation level. Estimates of primary productivity are relatively elevated for organic-rich beds. An increase in the flux of terrestrial helium (4Heterr) during the deposition of cherts may have been coincident with an increase in terrestrially derived nutrients. The presented results indicate great potential for the use of 3HeET to understand past oceanographic, climatic and sedimentological processes at high temporal resolution
The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae
Many bacteria use population density to control gene expression via quorum sensing. In Vibrio cholerae, quorum sensing coordinates virulence, biofilm formation, and DNA uptake by natural competence. The transcription factors AphA and HapR, expressed at low and high cell density respectively, play a key role. In particular, AphA triggers the entire virulence cascade upon host colonisation. In this work we have mapped genome-wide DNA binding by AphA. We show that AphA is versatile, exhibiting distinct modes of DNA binding and promoter regulation. Unexpectedly, whilst HapR is known to induce natural competence, we demonstrate that AphA also intervenes. Most notably, AphA is a direct repressor of tfoX, the master activator of competence. Hence, production of AphA markedly suppressed DNA uptake; an effect largely circumvented by ectopic expression of tfoX. Our observations suggest dual regulation of competence. At low cell density AphA is a master repressor whilst HapR activates the process at high cell density. Thus, we provide deep mechanistic insight into the role of AphA and highlight how V. cholerae utilises this regulator for diverse purposes
Enhancing the Teaching and Learning of Biometeorology in Higher Education
Information about the annual meeting organized by the organizations the International Society of Biometeorology (ISB) and the Students and New Professionals (SNP) held in Norfolk, Virginia from July 28 to August 1, 2016 is presented. The event was organized to improve the teaching methods of teachers and learning of students on high education biometeorology and the presentations, practical sessions and group discussions participated by attendees
WFPC2 Observations of the Hubble Deep Field-South
The Hubble Deep Field-South observations targeted a high-galactic-latitude
field near QSO J2233-606. We present WFPC2 observations of the field in four
wide bandpasses centered at roughly 300, 450, 606, and 814 nm. Observations,
data reduction procedures, and noise properties of the final images are
discussed in detail. A catalog of sources is presented, and the number counts
and color distributions of the galaxies are compared to a new catalog of the
HDF-N that has been constructed in an identical manner. The two fields are
qualitatively similar, with the galaxy number counts for the two fields
agreeing to within 20%. The HDF-S has more candidate Lyman-break galaxies at z
> 2 than the HDF-N. The star-formation rate per unit volume computed from the
HDF-S, based on the UV luminosity of high-redshift candidates, is a factor of
1.9 higher than from the HDF-N at z ~ 2.7, and a factor of 1.3 higher at z ~ 4.Comment: 93 pages, 25 figures; contains very long table
Core competencies for pain management: results of an interprofessional consensus summit.
ObjectiveThe objective of this project was to develop core competencies in pain assessment and management for prelicensure health professional education. Such core pain competencies common to all prelicensure health professionals have not been previously reported.MethodsAn interprofessional executive committee led a consensus-building process to develop the core competencies. An in-depth literature review was conducted followed by engagement of an interprofessional Competency Advisory Committee to critique competencies through an iterative process. A 2-day summit was held so that consensus could be reached.ResultsThe consensus-derived competencies were categorized within four domains: multidimensional nature of pain, pain assessment and measurement, management of pain, and context of pain management. These domains address the fundamental concepts and complexity of pain; how pain is observed and assessed; collaborative approaches to treatment options; and application of competencies across the life span in the context of various settings, populations, and care team models. A set of values and guiding principles are embedded within each domain.ConclusionsThese competencies can serve as a foundation for developing, defining, and revising curricula and as a resource for the creation of learning activities across health professions designed to advance care that effectively responds to pain
Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection
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