25,110 research outputs found
The use of a simplified structural model as an aid in the strain gage calibration of a complex wing
The use of a relatively simple structural model to characterize the load responses of strain gages located on various spars of a delta wing is examined. Strains measured during a laboratory load calibration of a wing structure are compared with calculations obtained from a simplified structural analysis model. Calculated and measured influence coefficient plots that show the shear, bending, and torsion characteristics of typical strain gage bridges are presented. Typical influence coefficient plots are shown for several load equations to illustrate the derivation of the equations from the component strain gage bridges. A relatively simple structural model was found to be effective in predicting the general nature of strain distributions and influence coefficient plots. The analytical processes are shown to be an aid in obtaining a good load calibration. The analytical processes cannot, however, be used in lieu of an actual load calibration of an aircraft wing
Cold Flow Determination of the Internal Flow Environment Around the Submerged TVC Nozzle for the Space Shuttle SRM
A series of subscale cold flow tests was performed to quantify the gas flow characteristics at the aft end of the Space Shuttle Solid Rocket Motor. This information was used to support the analyses of the redesigned nozzle/case joint. A portion of the thermal loads at the joint are due to the circumferential velocities and pressure gradients caused primarily by the gimbaling of the submerged nose TVC nozzle. When the nozzle centerline is vectored with respect to the motor centerline, asymmetries are set up in the flow field under the submerged nozzle and immediately adjacent to the nozzle/case joint. Specific program objectives included: determination of the effects of nozzle gimbal angle and propellant geometry on the circumferential flow field; measurement of the static pressure and gas velocities in the vicinity of the nozzle/case joint; use of scaling laws to apply the subscale cold flow data to the full scale SRM; and generation of data for use in validation of 3-D computational fluid dynamic, CFD, models of the SRM flow field. These tests were conducted in the NASA Marshall Space Flight Center Airflow Facility with a 7.5 percent scale model of the aft segment of the SRM. Static and dynamic pressures were measured in the model to quantify the flow field. Oil flow data was also acquired to obtain qualitative visual descriptions of the flow field. Nozzle gimbal angles of 0, 3.5, and 7 deg were used with propellant grain configurations corresponding to motor burn times of 0, 9, 19, and 114 seconds. This experimental program was successful in generating velocity and pressure gradient data for the flow field around the submerged nose nozzle of the Space Shuttle SRM at various burn times and gimbal angles. The nature of the flow field adjacent to the nozzle/case joint was determined with oil droplet streaks, and the velocity and pressure gradients were quantified with pitot probes and wall static pressure measurements. The data was applied to the full scale SRM thru a scaling analysis and the results compared well with the 3-D computational fluid dynamics computer model
Intravenous versus subcutaneous drug administration. Which do patients prefer? A systematic review
BACKGROUND:
Intravenous (IV) drug delivery is commonly used for its rapid administration and immediate drug effect. Most studies compare IV to subcutaneous (SC) delivery in terms of safety and efficacy, but little is known about what patients prefer.
METHODS:
A systematic review was conducted by searching seven electronic databases for articles published up to February 2014. Included studies were randomized controlled trials (RCTs) and/or crossover designs investigating patient preference for SC versus IV administration. The risk of bias in the RCTs was determined using the Cochrane Collaboration tool. Reviewers independently extracted data and assessed the risk of bias. Any discrepancies were resolved by consensus.
RESULTS:
The search identified 115 publications, but few (6/115) met the inclusion criteria. Patient populations and drugs investigated were diverse. Four of six studies demonstrated a clear patient preference for SC administration. Main factors associated with SC preference were time saving and the ability to have treatment at home. Only three studies used study-specific instruments to measure preference.
CONCLUSIONS:
Results suggest that patients prefer SC over IV delivery. Patient preference has clearly been neglected in clinical research, but it is important in medical decision making when choosing treatment methods as it has implications for adherence and quality of life. If the safety and efficacy of both administration routes are equivalent, then the most important factor should be patient preference as this will ensure optimal treatment adherence and ultimately improve patient experience or satisfaction. Future drug efficacy and safety studies should include contemporaneous, actual patient preference where possible, utilizing appropriate measures
Analysis of General Power Counting Rules in Effective Field Theory
We derive the general counting rules for a quantum effective field theory
(EFT) in dimensions. The rules are valid for strongly and weakly
coupled theories, and predict that all kinetic energy terms are canonically
normalized. They determine the energy dependence of scattering cross sections
in the range of validity of the EFT expansion. We show that the size of cross
sections is controlled by the power counting of EFT, not by chiral
counting, even for chiral perturbation theory (PT). The relation between
and is generalized to dimensions. We show that the
naive dimensional analysis counting is related to counting. The
EFT counting rules are applied to PT, low-energy weak interactions,
Standard Model EFT and the non-trivial case of Higgs EFT.Comment: V2: more details and examples added; version published in journal. 17
pages, 4 figures, 2 table
Bosonic Operator Methods for the Quark Model
Quark model matrix elements can be computed using bosonic operators and the
holomorphic representation for the harmonic oscillator. The technique is
illustrated for normal and exotic baryons for an arbitrary number of colors.
The computations are much simpler than those using conventional quark model
wavefunctions
Shocks in supersonic sand
We measure time-averaged velocity, density, and temperature fields for steady
granular flow past a wedge and calculate a speed of granular pressure
disturbances (sound speed) equal to 10% of the flow speed. The flow is
supersonic, forming shocks nearly identical to those in a supersonic gas.
Molecular dynamics simulations of Newton's laws and Monte Carlo simulations of
the Boltzmann equation yield fields in quantitative agreement with experiment.
A numerical solution of Navier-Stokes-like equations agrees with a molecular
dynamics simulation for experimental conditions excluding wall friction.Comment: 4 pages, 5 figure
On the structure of large N cancellations in baryon chiral perturbation theory
We show how to compute loop graphs in heavy baryon chiral perturbation theory
including the full functional dependence on the ratio of the Delta--nucleon
mass difference to the pion mass, while at the same time automatically
incorporating the 1/N cancellations that follow from the large-N spin-flavor
symmetry of baryons in QCD. The one-loop renormalization of the baryon axial
vector current is studied to demonstrate the procedure. A new cancellation is
identified in the one-loop contribution to the baryon axial vector current. We
show that loop corrections to the axial vector currents are exceptionally
sensitive to deviations of the ratios of baryon-pion axial couplings from SU(6)
values
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