フィリピンの小児デングウイルス感染症の重症化に、HLA-A*33:01アレルは防御的に働く

Dengue virus infection is a leading cause of morbidity among children in the Philippines in recent years. In order to investigate the association of HLA Class I and II alleles and dengue disease severity in a cohort of Filipino children, we performed a case control study in 2 hospitals in Metro Manila from June 2008 to December 2009. A total of 250 laboratory confirmed dengue patients and 300 healthy individuals aged 5 to 15 years old were typed for HLA-A, B and DRB1 alleles. The frequency of HLA-A*33:01 was significantly decreased in severe dengue (DHF/ DSS; Pc = 0.0016)) and DSS (Pc = 0.0032) compared to the background population. These findings support a previous study that this allele may confer protection against the severe form of dengue and provide the first evidence of HLA association with dengue in the Philippines. Future studies should be directed in investigating the possible mechanisms of protection.長崎大学学位論文 学位記番号:博(医歯薬)乙第39号 学位授与年月日:平成27年6月3日Author: Edelwisa Segubre Mercado, Fe Esperanza Espino, Ma. Lucila M. Perez, Josie M. Bilar, Jemimah Dawn P. Bajaro, Nguyen Tien Huy, Benilda Q Baello, Mihoko Kikuchi, Kenji HirayamaCitation: PLOS ONE, 10(2), e0115619; 2015Nagasaki University (長崎大学)論文博

Phenotype frequencies of HLA-A, HLA-B and DRB1 and their association with presence or absence of shock in severe dengue.

<p>^aThe number for each locus shows the number of successfully typed samples</p><p>^bCorrected P-values (Pc) were only calculated for loci with P-values less than 0.05</p><p>Phenotype frequencies of HLA-A, HLA-B and DRB1 and their association with presence or absence of shock in severe dengue.</p

Demographic, clinical and laboratory features of dengue patients classified using WHO 1997 classification.

<p>^aDSS vs DF, OR = 2.65 (1.3–5.3), <i>P</i> = 0.005</p><p>^bDSS vs. DF, OR = 3.89 (2.0–7.7), <i>P</i><0.0001 (Abdominal pain/tenderness); DSS vs. DF, OR = 34.17 (8.0 to 145.1), <i>P</i><0.0001, DHF vs. DF, <i>P</i><0.0001 (Clinical fluid accumulation); DSS vs. DF, OR = 2.47 (1.3–4.6), <i>P</i> = 0.0037 (Mucosal bleeding); DSS vs. DF, OR = 4.57(1.8–11.5), <i>P</i> = 0.0004, DHF vs. DF, <i>P</i> = 0.0405 (Increase in hematocrit with decrease in platelet count)</p><p>^cn.d. = not determined</p><p>Demographic, clinical and laboratory features of dengue patients classified using WHO 1997 classification.</p