515 research outputs found
The perception of bicycle crashes with and without motor vehicles : which crash types do older and middle-aged cyclists fear most?
A new southern Laramidian ankylosaurid, Akainacephalus johnsoni gen. et sp. nov., from the upper Campanian Kaiparowits Formation of southern Utah, USA
A partial ankylosaurid skeleton from the upper Campanian Kaiparowits Formation of southern Utah is recognized as a new taxon, Akainacephalus johnsoni, gen. et sp. nov. The new taxon documents the first record of an associated ankylosaurid skull and postcranial skeleton from the Kaiparowits Formation. Preserved material includes a complete skull, much of the vertebral column, including a complete tail club, a nearly complete synsacrum, several fore- and hind limb elements, and a suite of postcranial osteoderms, making Akainacephalus johnsoni the most complete ankylosaurid from the Late Cretaceous of southern Laramidia. Arrangement and morphology of cranial ornamentation in Akainacephalus johnsoni is strikingly similar to Nodocephalosaurus kirtlandensis and some Asian ankylosaurids (e.g., Saichania chulsanensis, Pinacosaurus grangeri, and Minotaurasaurus ramachandrani); the cranium is densely ornamented with symmetrically arranged and distinctly raised ossified caputegulae which are predominantly distributed across the dorsal and dorsolateral regions of the nasals, frontals, and orbitals. Cranial caputegulae display smooth surface textures with minor pitting and possess a distinct conical to pyramidal morphology which terminates in a sharp apex. Character analysis suggests a close phylogenetic relationship with N. kirtlandensis, M. ramachandrani, Tarchia teresae, and S. chulsanensis, rather than with Late Cretaceous northern Laramidian ankylosaurids (e.g., Euoplocephalus tutus, Anodontosaurus lambei, and Ankylosaurus magniventris). These new data are consistent with evidence for distinct northern and southern biogeographic provinces in Laramidia during the late Campanian. The addition of this new ankylosaurid taxon from southern Utah enhances our understanding of ankylosaurid diversity and evolutionary relationships. Potential implications for the geographical distribution of Late Cretaceous ankylosaurid dinosaurs throughout the Western Interior suggest multiple time-transgressive biogeographic dispersal events from Asia into Laramidia
Rising and settling 2D cylinders with centre-of-mass offset
Rotational effects are commonly neglected when considering the dynamics of
freely rising or settling isotropic particles. Here, we demonstrate that
particle rotations play an important role for rising as well as for settling
cylinders in situations when mass eccentricity, and thereby a new pendulum
timescale, is introduced to the system. We employ two-dimensional simulations
to study the motion of a single cylinder in a quiescent unbounded
incompressible Newtonian fluid. This allows us to vary the Galileo number,
density ratio, relative moment of inertia, and Centre-Of-Mass offset (COM)
systematically and beyond what is feasible experimentally. For certain buoyant
density ratios, the particle dynamics exhibit a resonance mode, during which
the coupling via the Magnus lift force causes a positive feedback between
translational and rotational motions. This mode results in vastly different
trajectories with significantly larger rotational and translational amplitudes
and an increase of the drag coefficient easily exceeding a factor two. We
propose a simple model that captures how the occurrence of the COM offset
induced resonance regime varies, depending on the other input parameters,
specifically the density ratio, the Galileo number, and the relative moment of
inertia. Remarkably, depending on the input parameters, resonance can be
observed for centre-of-mass offsets as small as a few percent of the particle
diameter, showing that the particle dynamics can be highly sensitive to this
parameter.Comment: 32 pages, 13 figure
Averaging in Cosmology
In this paper we discuss the effect of local inhomogeneities on the global
expansion of nearly FLRW universes, in a perturbative setting. We derive a
generic linearized averaging operation for metric perturbations from basic
assumptions, and we explicify the issue of gauge invariance. We derive a gauge
invariant expression for the back-reaction of density inhomogeneities on the
global expansion of perturbed FLRW spacetimes, in terms of observable
quantities, and we calculate the effect quantitatively. Since we do not adopt a
comoving gauge, our result incorporates the back-reaction on the metric due to
scalar velocity and vorticity perturbations. The results are compared with the
results by other authors in this field.Comment: 24 pages, Latex, accepted for publication in Phys. Rev.
Dynamics of Generalized Assisted Inflation
We study the dynamics of multiple scalar fields and a barotropic fluid in an
FLRW-universe. The scalar potential is a sum of exponentials. All critical
points are constructed and these include scaling and de Sitter solutions. A
stability analysis of the critical points is performed for generalized assisted
inflation, which is an extension of assisted inflation where the fields
mutually interact. Effects in generalized assisted inflation which differ from
assisted inflation are emphasized. One such a difference is that an
(inflationary) attractor can exist if some of the exponential terms in the
potential are negative.Comment: 27 page
Seven-branes and Supersymmetry
We re-investigate the construction of half-supersymmetric 7-brane solutions
of IIB supergravity. Our method is based on the requirement of having globally
well-defined Killing spinors and the inclusion of SL(2,Z)-invariant source
terms. In addition to the well-known solutions going back to Greene, Shapere,
Vafa and Yau we find new supersymmetric configurations, containing objects
whose monodromies are not related to the monodromy of a D7-brane by an SL(2,Z)
transformation.Comment: 31 pages, 3 figure
The international normalised ratio to monitor coagulation factor production during normothermic machine perfusion of human donor livers
Background: Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. As the liver produces most of the haemostatic proteins, coagulation assays such as the International Normalised Ratio (INR) performed in perfusate may be useful to assess hepatocellular function of donor livers undergoing NMP. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays.Methods: Thirty donor livers that underwent NMP were retrospectively included in this study, of which 18 were subsequently transplanted. We measured INRs in perfusate in presence or absence of exogenously added fibrinogen and/or polybrene. Additionally, we prospectively included 14 donor livers that underwent NMP (of which 11 were transplanted) and measured INR using both a laboratory coagulation analyser and a point-of-care device.Results: In untreated perfusate samples, the INR was above the detection limit in all donor livers. Addition of both fibrinogen and polybrene was required for adequate INR assessment. INRs decreased over time and detectable perfusate INR values were found in 17/18 donor livers at the end of NMP. INR results were similar between the coagulation analyser and the point-of-care device, but did not correlate with established hepatocellular viability criteria.Conclusions: Most of the donor livers that were transplanted showed a detectable perfusate INR at the end of NMP, but samples require processing to allow for INR measurements using laboratory coagulation analysers. Point-of-care devices bypass this need for processing. The INR does not correlate with established viability criteria and might therefore have additional predictive value.</p
The international normalised ratio to monitor coagulation factor production during normothermic machine perfusion of human donor livers
Background: Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. As the liver produces most of the haemostatic proteins, coagulation assays such as the International Normalised Ratio (INR) performed in perfusate may be useful to assess hepatocellular function of donor livers undergoing NMP. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays. Methods: Thirty donor livers that underwent NMP were retrospectively included in this study, of which 18 were subsequently transplanted. We measured INRs in perfusate in presence or absence of exogenously added fibrinogen and/or polybrene. Additionally, we prospectively included 14 donor livers that underwent NMP (of which 11 were transplanted) and measured INR using both a laboratory coagulation analyser and a point-of-care device. Results: In untreated perfusate samples, the INR was above the detection limit in all donor livers. Addition of both fibrinogen and polybrene was required for adequate INR assessment. INRs decreased over time and detectable perfusate INR values were found in 17/18 donor livers at the end of NMP. INR results were similar between the coagulation analyser and the point-of-care device, but did not correlate with established hepatocellular viability criteria. Conclusions: Most of the donor livers that were transplanted showed a detectable perfusate INR at the end of NMP, but samples require processing to allow for INR measurements using laboratory coagulation analysers. Point-of-care devices bypass this need for processing. The INR does not correlate with established viability criteria and might therefore have additional predictive value.</p
The international normalised ratio to monitor coagulation factor production during normothermic machine perfusion of human donor livers
Background: Normothermic machine perfusion (NMP) of donor livers allows for new diagnostic and therapeutic strategies. As the liver produces most of the haemostatic proteins, coagulation assays such as the International Normalised Ratio (INR) performed in perfusate may be useful to assess hepatocellular function of donor livers undergoing NMP. However, high concentrations of heparin and low levels of fibrinogen may affect coagulation assays. Methods: Thirty donor livers that underwent NMP were retrospectively included in this study, of which 18 were subsequently transplanted. We measured INRs in perfusate in presence or absence of exogenously added fibrinogen and/or polybrene. Additionally, we prospectively included 14 donor livers that underwent NMP (of which 11 were transplanted) and measured INR using both a laboratory coagulation analyser and a point-of-care device. Results: In untreated perfusate samples, the INR was above the detection limit in all donor livers. Addition of both fibrinogen and polybrene was required for adequate INR assessment. INRs decreased over time and detectable perfusate INR values were found in 17/18 donor livers at the end of NMP. INR results were similar between the coagulation analyser and the point-of-care device, but did not correlate with established hepatocellular viability criteria. Conclusions: Most of the donor livers that were transplanted showed a detectable perfusate INR at the end of NMP, but samples require processing to allow for INR measurements using laboratory coagulation analysers. Point-of-care devices bypass this need for processing. The INR does not correlate with established viability criteria and might therefore have additional predictive value.</p
Variational dynamics in open spacetimes
We study the effect of non-vanishing surface terms at spatial infinity on the
dynamics of a scalar field in an open FLRW spacetime. Starting from the
path-integral formulation of quantum field theory we argue that classical
physics is described by field configurations which extremize the action
functional in the space of field configurations for which the variation of the
action is well defined. Since these field configurations are not required to
vanish outside a bounded domain, there is generally a non-vanishing
contribution of a surface term to the variation of the action. We then
investigate whether this surface term has an effect on the dynamics of the
action-extremizing field configurations. This question appears to be
surprisingly nontrivial in the case of the open FLRW geometry, since surface
terms tend to grow as fast as volume terms in the infinite volume limit. We
find that surface terms can be important for the dynamics of the field at a
classical and at a quantum level, when there are supercurvature perturbations.Comment: 21 pages, Latex, no figure
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