Uticaj izbora modela utvrđivanja transfernih cena na performanse poslovanja multidivizionog preduzeća

The aim of this study is examining the relationship between the presence of insulin rОsТstaЧМО (IR) aЧН tСО ε4 allОlО ТЧ tСО APOE РОЧО, ТЧНОpОЧНОЧtlв aЧН assШМТatОН with the existence, severity and pattern of cognitive impairment in patients with MS. According to our hypothesis the existence of cognitive impairment is positively МШrrОlatОН аТtС tСО prОsОЧМО ШП ТЧsulТЧ rОsТstaЧМО aЧН / Шr ε4 allОlО ШП tСО APOE РОЧО. Methods: Clinical observational cross-sectional study includes 81 patients diagnosed with clinically definite MS with RR disease course. The total group of respondents is composed of subgroups: 50 patients are receiving the immunomodulatory therapy IFNβ1b (Betaferon) from the moment of diagnosis and 31 patients did not, until the beginning of the study, receive any therapy that modifies the natural course of the disease. In all subjects we determined: the presence of insulin resistance (HOMA index); glucose intolerance using an oral glucose tolerance test (OGTT); the APOE gene polymorphisms; cognitive status using four neuropsychological tests taken from a neuropsychological battery, "The Brief Repeatable Battery of Neuropsychological Tests", which examined the most frequently impaired cognitive domains. Results: The presence of cognitive impairment was 39.51.The most common is episodic memory impairment, in 67% of patients. Significantly higher incidence of patients with poor achievements in the visual memory test was in the group with an impaired glucose tolerance. (80% vs. 54.10%, p = 0.04). We determined a significant independent negative ОППОМt ШП tСО prОsОЧМО ШП ε4 allОlО ТЧ tСО ApШE РОЧО ШЧ tСО ШММurrОЧМО ШП ЦТlН МШРЧТtТvО impairment (OR = 5:55; 95% CI, 0.96-32.25, p = 0.049). TСО prОsОЧМО ШП tСО ε4 allОlО represents 5.5 times the risk that the patient will develop a mild cognitive deficit independently from the presence of IR indicators. It was found that the predictors of mild cognitive deficits and memory impairment were female sex, longer illness duration, fewer relapses and more progressive course of the disease. The predictors of cognitive impairment are longer and more progressive course of the disease. Application of the immunomodulatory therapy IFNβ1 sСШаОН ЧШ assШМТatТШЧ аТtС aЧв ШП tСО tОstОН parameters. Conclusion: This study examines for the first time the association between glucose and insulin metabolic disorders with the presence and characteristics of cognitive impairment in RR MS, indepenНОЧtlв aЧН assШМТatОН аТtС tСО ОбТstОЧМО ШП ε4 allОlОs ТЧ tСО APOE РОЧО. A ЦШrО ПrОquОЧt prОsОЧМО ШП ε4 allОlО aЦШЧР patТОЧts аТtС ЦТlН cognitive deficit in comparison to the cognitively preserved ones makes them a group of interest for further observation because of the possible greater vulnerability to future cognitive impairment. The study contributes to the early detection and better understanding of cognitive impairment in MS which is present from the earliest stages of the disease. This is important in predicting the course of the disease,the degree of functional disability and represents an important factor in determining the therapy that alters the natural course of the disease

Early electrophysiological markers of the sleep and motor control disorders during aging in rats with neurodegeneration of the cholinergic neurons

The aim of the present doctoral dissertation was to evaluate the impact of aging during sleep in the rat models of Alzheimer’s and Parkinson’s disease cholinergic neuropathology, and to determine the possible different and earlier onset of age-related sleep disorder during healthy aging and aging with the neurodegenerative diseases. We used the bilateral nucleus basalis (NB) and nucleus pedunculopontinus tegmentalis (PPT) lesioned rats as the in vivo models of functionally distinct cholinergic neuropathology, and we followed the impact of aging on sleep architecture, the electroencephalographic (EEG) microstructure and motor control across sleep/wake states. We evidenced the topographically distinct impact of healthy aging on sleep architecture and motor control within the sensorimotor (SMCx) vs. motor cortex (MCx). Whereas healthy aging consistently altered only the SMCx sleep architecture, it increased the delta and beta cortical drives from both cortices during Wake, but only through the MCx drive during rapid eye movement sleep (REM). Our results have shown for the first time that the earliest signs of aging during distinct cholinergic neuropathology were expressed through a different and topographically specific EEG microstructure during REM. EEG delta amplitude attenuation within the SMCx was the earliest sign of aging in the NB lesion, whereas EEG sigma amplitude augmentation within the MCx was the earliest sign of aging in the PPT lesion during REM. In addition, aging was differently expressed through the SMCx drive alterations, but it was commonly expressed through the MCx drive alterations during all sleep/wake states. This doctoral dissertation provided for the first time an evidence of distinct REM sleep disorders and sleep state related cortical drives as the signs of aging onset during functionally distinct cholinergic neuropathologies.Cilj ove doktorske disertacije bio je da ispita uticaj starenja na spavanje u eksperimentalnim modelima holinergičke neuropatologije Alchajmerove i Parkinsonove bolesti, i da pronađe najranije znake poremećaja spavanja u fiziološkom starenju i u starenju sa neurodegenerativnim bolestima. Uticaj starenja na arhitekturu spavanja, elektroencefalografsku (EEG) mikrostrukturu i motornu kontrolu, u toku svake faze spavanja, je praćen u eksperimentalnim modelima bilateralnih oštećenja jedara nucleus basalis (NB) i nucleus pedunculopontinus tegmentalis (PPT) u pacova, kao eksperimentalnim in vivo modelima funkcionalno različitih holinergičkih neuropatologija. Fiziološko starenje dovodi do topografski različitih promena arhitekture spavanja i motorne kontrole iz senzomotorne kore (SMCx) u odnosu na motornu koru (MCx). Pored promena arhitekture spavanja koje su se javile samo u SMCx, fiziološko starenje dovodi i do povećanja propagacije delta i beta oscilacija iz obe kore za vreme budnosti, ali samo iz MCx za vreme REM faze spavanja. Najraniji znaci starenja u eksperimentalnim modelima funkcionalno različitih holinergičkih neuropatologija, dokazani po prvi put, predstavljaju topografski specifične razlike u EEG mikrostrukturi za vreme REM faze spavanja. Smanjenje delta EEG relativne amplitude u SMCx predstavlja najraniji znak starenja kod NB lediranih pacova, dok povećanje sigma EEG relativne amplitude u MCx predstavlja najraniji znak starenja kod PPT lediranih pacova, za vreme REM faze spavanja. Pored toga, starenjem izazvane promene su različito izražene kroz mišićnu kontrolu iz SMCx, a istovremeno i istovetno izražene iz MCx u toku svih faza spavanja. Ova doktorska disertacija je po prvi put dokazala različite poremećaje REM faze spavanja i motorne kontrole u toku spavanja, kao najranije znake početka starenja u funkcionalno različitim holinergičkim neuropatologijama.University of Belgrade, Faculty of Biology (2017

Weighted Automata over Vector Spaces

In this paper we deal with three models of weighted automata that take weights in the field of real numbers. The first of these models are classical weighted finite automata, the second one are crisp-deterministic weighted automata, and the third one are weighted automata over a vector space. We explore the interrelationships between weighted automata over a vector space and other two models.Comment: In Proceedings AFL 2023, arXiv:2309.0112

Early electrophysiological markers of the sleep and motor control disorders during aging in rats with neurodegeneration of the cholinergic neurons

The aim of the present doctoral dissertation was to evaluate the impact of aging during sleep in the rat models of Alzheimer’s and Parkinson’s disease cholinergic neuropathology, and to determine the possible different and earlier onset of age-related sleep disorder during healthy aging and aging with the neurodegenerative diseases. We used the bilateral nucleus basalis (NB) and nucleus pedunculopontinus tegmentalis (PPT) lesioned rats as the in vivo models of functionally distinct cholinergic neuropathology, and we followed the impact of aging on sleep architecture, the electroencephalographic (EEG) microstructure and motor control across sleep/wake states. We evidenced the topographically distinct impact of healthy aging on sleep architecture and motor control within the sensorimotor (SMCx) vs. motor cortex (MCx). Whereas healthy aging consistently altered only the SMCx sleep architecture, it increased the delta and beta cortical drives from both cortices during Wake, but only through the MCx drive during rapid eye movement sleep (REM). Our results have shown for the first time that the earliest signs of aging during distinct cholinergic neuropathology were expressed through a different and topographically specific EEG microstructure during REM. EEG delta amplitude attenuation within the SMCx was the earliest sign of aging in the NB lesion, whereas EEG sigma amplitude augmentation within the MCx was the earliest sign of aging in the PPT lesion during REM. In addition, aging was differently expressed through the SMCx drive alterations, but it was commonly expressed through the MCx drive alterations during all sleep/wake states. This doctoral dissertation provided for the first time an evidence of distinct REM sleep disorders and sleep state related cortical drives as the signs of aging onset during functionally distinct cholinergic neuropathologies.Cilj ove doktorske disertacije bio je da ispita uticaj starenja na spavanje u eksperimentalnim modelima holinergičke neuropatologije Alchajmerove i Parkinsonove bolesti, i da pronađe najranije znake poremećaja spavanja u fiziološkom starenju i u starenju sa neurodegenerativnim bolestima. Uticaj starenja na arhitekturu spavanja, elektroencefalografsku (EEG) mikrostrukturu i motornu kontrolu, u toku svake faze spavanja, je praćen u eksperimentalnim modelima bilateralnih oštećenja jedara nucleus basalis (NB) i nucleus pedunculopontinus tegmentalis (PPT) u pacova, kao eksperimentalnim in vivo modelima funkcionalno različitih holinergičkih neuropatologija. Fiziološko starenje dovodi do topografski različitih promena arhitekture spavanja i motorne kontrole iz senzomotorne kore (SMCx) u odnosu na motornu koru (MCx). Pored promena arhitekture spavanja koje su se javile samo u SMCx, fiziološko starenje dovodi i do povećanja propagacije delta i beta oscilacija iz obe kore za vreme budnosti, ali samo iz MCx za vreme REM faze spavanja. Najraniji znaci starenja u eksperimentalnim modelima funkcionalno različitih holinergičkih neuropatologija, dokazani po prvi put, predstavljaju topografski specifične razlike u EEG mikrostrukturi za vreme REM faze spavanja. Smanjenje delta EEG relativne amplitude u SMCx predstavlja najraniji znak starenja kod NB lediranih pacova, dok povećanje sigma EEG relativne amplitude u MCx predstavlja najraniji znak starenja kod PPT lediranih pacova, za vreme REM faze spavanja. Pored toga, starenjem izazvane promene su različito izražene kroz mišićnu kontrolu iz SMCx, a istovremeno i istovetno izražene iz MCx u toku svih faza spavanja. Ova doktorska disertacija je po prvi put dokazala različite poremećaje REM faze spavanja i motorne kontrole u toku spavanja, kao najranije znake početka starenja u funkcionalno različitim holinergičkim neuropatologijama.University of Belgrade, Faculty of Biology (2017

Early electrophysiological markers of the sleep and motor control disorders during aging in rats with neurodegeneration of the cholinergic neurons

Cilj ove doktorske disertacije bio je da ispita uticaj starenja na spavanje u eksperimentalnim modelima holinergičke neuropatologije Alchajmerove i Parkinsonove bolesti, i da pronađe najranije znake poremećaja spavanja u fiziološkom starenju i u starenju sa neurodegenerativnim bolestima. Uticaj starenja na arhitekturu spavanja, elektroencefalografsku (EEG) mikrostrukturu i motornu kontrolu, u toku svake faze spavanja, je praćen u eksperimentalnim modelima bilateralnih oštećenja jedara nucleus basalis (NB) i nucleus pedunculopontinus tegmentalis (PPT) u pacova, kao eksperimentalnim in vivo modelima funkcionalno različitih holinergičkih neuropatologija. Fiziološko starenje dovodi do topografski različitih promena arhitekture spavanja i motorne kontrole iz senzomotorne kore (SMCx) u odnosu na motornu koru (MCx). Pored promena arhitekture spavanja koje su se javile samo u SMCx, fiziološko starenje dovodi i do povećanja propagacije delta i beta oscilacija iz obe kore za vreme budnosti, ali samo iz MCx za vreme REM faze spavanja. Najraniji znaci starenja u eksperimentalnim modelima funkcionalno različitih holinergičkih neuropatologija, dokazani po prvi put, predstavljaju topografski specifične razlike u EEG mikrostrukturi za vreme REM faze spavanja. Smanjenje delta EEG relativne amplitude u SMCx predstavlja najraniji znak starenja kod NB lediranih pacova, dok povećanje sigma EEG relativne amplitude u MCx predstavlja najraniji znak starenja kod PPT lediranih pacova, za vreme REM faze spavanja. Pored toga, starenjem izazvane promene su različito izražene kroz mišićnu kontrolu iz SMCx, a istovremeno i istovetno izražene iz MCx u toku svih faza spavanja...The aim of the present doctoral dissertation was to evaluate the impact of aging during sleep in the rat models of Alzheimer’s and Parkinson’s disease cholinergic neuropathology, and to determine the possible different and earlier onset of age-related sleep disorder during healthy aging and aging with the neurodegenerative diseases. We used the bilateral nucleus basalis (NB) and nucleus pedunculopontinus tegmentalis (PPT) lesioned rats as the in vivo models of functionally distinct cholinergic neuropathology, and we followed the impact of aging on sleep architecture, the electroencephalographic (EEG) microstructure and motor control across sleep/wake states. We evidenced the topographically distinct impact of healthy aging on sleep architecture and motor control within the sensorimotor (SMCx) vs. motor cortex (MCx). Whereas healthy aging consistently altered only the SMCx sleep architecture, it increased the delta and beta cortical drives from both cortices during Wake, but only through the MCx drive during rapid eye movement sleep (REM). Our results have shown for the first time that the earliest signs of aging during distinct cholinergic neuropathology were expressed through a different and topographically specific EEG microstructure during REM. EEG delta amplitude attenuation within the SMCx was the earliest sign of aging in the NB lesion, whereas EEG sigma amplitude augmentation within the MCx was the earliest sign of aging in the PPT lesion during REM. In addition, aging was differently expressed through the SMCx drive alterations, but it was commonly expressed through the MCx drive alterations during all sleep/wake states..