94 research outputs found

    Sparser Johnson-Lindenstrauss Transforms

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    We give two different and simple constructions for dimensionality reduction in ℓ2\ell_2 via linear mappings that are sparse: only an O(ε)O(\varepsilon)-fraction of entries in each column of our embedding matrices are non-zero to achieve distortion 1+ε1+\varepsilon with high probability, while still achieving the asymptotically optimal number of rows. These are the first constructions to provide subconstant sparsity for all values of parameters, improving upon previous works of Achlioptas (JCSS 2003) and Dasgupta, Kumar, and Sarl\'{o}s (STOC 2010). Such distributions can be used to speed up applications where ℓ2\ell_2 dimensionality reduction is used.Comment: v6: journal version, minor changes, added Remark 23; v5: modified abstract, fixed typos, added open problem section; v4: simplified section 4 by giving 1 analysis that covers both constructions; v3: proof of Theorem 25 in v2 was written incorrectly, now fixed; v2: Added another construction achieving same upper bound, and added proof of near-tight lower bound for DKS schem

    Bounded Independence Fools Degree-2 Threshold Functions

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    Let x be a random vector coming from any k-wise independent distribution over {-1,1}^n. For an n-variate degree-2 polynomial p, we prove that E[sgn(p(x))] is determined up to an additive epsilon for k = poly(1/epsilon). This answers an open question of Diakonikolas et al. (FOCS 2009). Using standard constructions of k-wise independent distributions, we obtain a broad class of explicit generators that epsilon-fool the class of degree-2 threshold functions with seed length log(n)*poly(1/epsilon). Our approach is quite robust: it easily extends to yield that the intersection of any constant number of degree-2 threshold functions is epsilon-fooled by poly(1/epsilon)-wise independence. Our results also hold if the entries of x are k-wise independent standard normals, implying for example that bounded independence derandomizes the Goemans-Williamson hyperplane rounding scheme. To achieve our results, we introduce a technique we dub multivariate FT-mollification, a generalization of the univariate form introduced by Kane et al. (SODA 2010) in the context of streaming algorithms. Along the way we prove a generalized hypercontractive inequality for quadratic forms which takes the operator norm of the associated matrix into account. These techniques may be of independent interest.Comment: Using v1 numbering: removed Lemma G.5 from the Appendix (it was wrong). Net effect is that Theorem G.6 reduces the m^6 dependence of Theorem 8.1 to m^4, not m^

    FUTURE CARDIAC EVENTS IN NORMALLY DIAGNOSED GATED MYOCARDIAL PERFUSION SPECT (GSPECT)

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    Coronary heart disease (CHD) is a major cause of mortality and morbidity in Europe and USA and its management consumes a large proportion of national healthcare budgets. Many studies had tested the prognostic value of a normal myocardial perfusion scintigraphy; they concluded that a normal MPI study is associated with a very low rate of future cardiac events. In view of the above this study is designed to determine the risk of future cardiac events after normal MPS in local population. Methods: This was a retrospective observational registry performed in a single center in the Kingdom of Saudi Arabia. The data were collected from the nuclear medicine database identifying all the reported normal myocardial perfusion scans between January 2008 and December 2011 . Results: There were 290 patients identified with normal cardiac nuclear scans in the pre-specified time frame. Basic patient demographics were outlined and the patients’ charts were reviewed looking for any major cardiac events such as MI or sudden death. Mean follow up was 14.8 months. There were 2 patients that were admitted with NSTEMI and went on to have diagnostic angiograms. One of those two patients underwent percutaneous coronary intervention with stenting. The other patient had nonobstructive CAD and was advised for medical management only. These findings are consistent with a 0.7% risk of cardiac events after a negative scan Conclusion: The above findings demonstrate that the risk of major cardiac events after a negative nuclear cardiac scan is low and is in keeping with the international statistics available

    FUTURE CARDIAC EVENTS IN NORMALLY DIAGNOSED GATED MYOCARDIAL PERFUSION SPECT (GSPECT)

    Get PDF
    Coronary heart disease (CHD) is a major cause of mortality and morbidity in Europe and USA and its management consumes a large proportion of national healthcare budgets. Many studies had tested the prognostic value of a normal myocardial perfusion scintigraphy; they concluded that a normal MPI study is associated with a very low rate of future cardiac events. In view of the above this study is designed to determine the risk of future cardiac events after normal MPS in local population. Methods: This was a retrospective observational registry performed in a single center in the Kingdom of Saudi Arabia. The data were collected from the nuclear medicine database identifying all the reported normal myocardial perfusion scans between January 2008 and December 2011 . Results: There were 290 patients identified with normal cardiac nuclear scans in the pre-specified time frame. Basic patient demographics were outlined and the patients’ charts were reviewed looking for any major cardiac events such as MI or sudden death. Mean follow up was 14.8 months. There were 2 patients that were admitted with NSTEMI and went on to have diagnostic angiograms. One of those two patients underwent percutaneous coronary intervention with stenting. The other patient had nonobstructive CAD and was advised for medical management only. These findings are consistent with a 0.7% risk of cardiac events after a negative scan Conclusion: The above findings demonstrate that the risk of major cardiac events after a negative nuclear cardiac scan is low and is in keeping with the international statistics available
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