GAN-Based Super-Resolution And Segmentation Of Retinal Layers In Optical Coherence Tomography Scans

Optical Coherence Tomography (OCT) has been identified as a noninvasive and cost-effective imaging modality for identifying potential biomarkers for Alzheimer\u27s diagnosis and progress detection. Current hypotheses indicate that retinal layer thickness, which can be assessed via OCT scans, is an efficient biomarker for identifying Alzheimer\u27s disease. Due to factors such as speckle noise, a small target region, and unfavorable imaging conditions manual segmentation of retina layers is a challenging task. Therefore, as a reasonable first step, this study focuses on automatically segmenting retinal layers to separate them for subsequent investigations. Another important challenge commonly faced is the lack of clarity of the layer boundaries in retina OCT scans, which compels the research of super-resolving the images for improved clarity. Deep learning pipelines have stimulated substantial progress for the segmentation tasks. Generative adversarial networks (GANs) are a prominent field of deep learning which achieved astonishing performance in semantic segmentation. Conditional adversarial networks as a general-purpose solution to image-to-image translation problems not only learn the mapping from the input image to the output image but also learn a loss function to train this mapping. We propose a GAN-based segmentation model and evaluate incorporating popular networks, namely, U-Net and ResNet, in the GAN architecture with additional blocks of transposed convolution and sub-pixel convolution for the task of upscaling OCT images from low to high resolution by a factor of four. We also incorporate the Dice loss as an additional reconstruction loss term to improve the performance of this joint optimization task. Our best model configuration empirically achieved the Dice coefficient of 0.867 and mIOU of 0.765

Learning orientation and innovation performance: The mediating role of operations strategy and supply chain integration

Purpose: The purpose of this study is to explore the effect of operations strategy (cost, quality, flexibility, and delivery) and supply chain integration on innovation performance under influence of learning orientation. Design/Methodology/approach: Taking a quantitative and deductive approach, a conceptual framework was developed and tested by analyzing data gathered through survey questionnaire from 243 UK manufacturing firms using structural equation modeling. Findings: Our findings show that learning orientation influences operations strategy and supply chain integration, but it does not have a direct impact on innovation performance. Additionally, quality and flexibility strategies affect innovation performance and supply chain integration positively, while cost and delivery strategies don't have a significant effect on these variables. Research limitations/implications: Operations strategy types (cost, quality, flexibility and delivery) were studied as distinct variables whereas supply chain integration also has several dimensions but that has not been investigated separately in the present research. The findings are also based on limited 243 responses from UK manufacturing firms. Practical implications: Innovation performance of manufacturing firms can be improved through a more integrated supply chain if managers embody flexibility and quality capabilities in their operations and become learning oriented. Originality/value: The effect of supply chain integration on innovation performance and learning orientation on supply chain integration and operations strategy types have not been fully explored in literature. Also, having all four operations strategy types in a direct relation to supply chain integration and innovation performance is another original aspect of the current study

Superresolution and Segmentation of OCT scans using Multi-Stage adversarial Guided Attention Training

Optical coherence tomography (OCT) is one of the non-invasive and easy-to-acquire biomarkers (the thickness of the retinal layers, which is detectable within OCT scans) being investigated to diagnose Alzheimer's disease (AD). This work aims to segment the OCT images automatically; however, it is a challenging task due to various issues such as the speckle noise, small target region, and unfavorable imaging conditions. In our previous work, we have proposed the multi-stage & multi-discriminatory generative adversarial network (MultiSDGAN) to translate OCT scans in high-resolution segmentation labels. In this investigation, we aim to evaluate and compare various combinations of channel and spatial attention to the MultiSDGAN architecture to extract more powerful feature maps by capturing rich contextual relationships to improve segmentation performance. Moreover, we developed and evaluated a guided mutli-stage attention framework where we incorporated a guided attention mechanism by forcing an L-1 loss between a specifically designed binary mask and the generated attention maps. Our ablation study results on the WVU-OCT data-set in five-fold cross-validation (5-CV) suggest that the proposed MultiSDGAN with a serial attention module provides the most competitive performance, and guiding the spatial attention feature maps by binary masks further improves the performance in our proposed network. Comparing the baseline model with adding the guided-attention, our results demonstrated relative improvements of 21.44% and 19.45% on the Dice coefficient and SSIM, respectively.Comment: 5 pages,conferenc