2,348 research outputs found

    What does it take to learn in next generation learning spaces?

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    This chapter identifies the attributes that learners need in order to learn effectively in new technology rich educational environments. There are a number of different ways of synthesising the findings from this emerging literature which relies heavily on qualitative research. This chapter reports on a literature review which adopted a deliberately interpretative qualitative meta-analysis, synthesising the findings from 15 key studies. As such, the chapter demonstrates a way of reviewing and compiling current research. The synthesis resulted in the identification of six attributes that learners need to do well in next generation learning spaces. These are: engaged, connected, confident, adaptable, intentional and self-aware. Although some of these attributes are applicable to all learning contexts, those of being connected, confident, adaptable and intentional seem to be particularly important in learning in next generation learning spaces. The challenge is to design learning activities that encourage and reward the development of these attributes. The hope is that through both its findings and its method, this chapter provokes debate on what it now means to be a successful learner in today’s technology rich world

    Wear Behavior of Low-Cost, Lightweight TiC/Ti-6Al-4V Composite Under Fretting: Effectiveness of Solid-Film Lubricant Counterparts

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    The wear behavior of low-cost, lightweight 10-wt% TiC-particulate-reinforced Ti-6Al-4V matrix composite (TiC/Ti- 6Al-4V) was examined under fretting at 296, 423, and 523 K in air. Bare 10-wt% TiC/Ti-6Al-4V hemispherical pins were used in contact with dispersed multiwalled carbon nanotubes (MWNTs), magnetron-sputtered diamondlike carbon/chromium (DLC/Cr), magnetron-sputtered graphite-like carbon/chromium (GLC/Cr), and magnetron-sputtered molybdenum disulphide/titanium (MoS2/Ti) deposited on Ti-6Al-4V, Ti-48Al-2Cr-2Nb, and nickel-based superalloy 718. When TiC/Ti-6Al-4V was brought into contact with bare Ti-6Al-4V, bare Ti-48Al-2Cr-2Nb, and bare nickel-based superalloy 718, strong adhesion, severe galling, and severe wear occurred. However, when TiC/Ti-6Al-4V was brought into contact with MWNT, DLC/Cr, GLC/Cr, and MoS2/Ti coatings, no galling occurred in the contact, and relatively minor wear was observed regardless of the coating. All the solid-film lubricants were effective from 296 to 523 K, but the effectiveness of the MWNT, DLC/Cr, GLC/Cr, and MoS2/Ti coatings decreased as temperature increased

    Proteomic analysis of Plasmodium falciparum histone deacetylase 1 complex proteins

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    Plasmodium falciparum histone deacetylases (PfHDACs) are an important class of epigenetic regulators that alter protein lysine acetylation, contributing to regulation of gene expression and normal parasite growth and development. PfHDACs are therefore under investigation as drug targets for malaria. Despite this, our understanding of the biological roles of these enzymes is only just beginning to emerge. In higher eukaryotes, HDACs function as part of multi-protein complexes and act on both histone and non-histone substrates. Here, we present a proteomics analysis of PfHDAC1 immunoprecipitates, identifying 26 putative P. falciparum complex proteins in trophozoite-stage asexual intraerythrocytic parasites. The co-migration of two of these (P. falciparum heat shock proteins 70-1 and 90) with PfHDAC1 was validated using Blue Native PAGE combined with Western blot. These data provide a snapshot of possible PfHDAC1 interactions and a starting point for future studies focused on elucidating the broader function of PfHDACs in Plasmodium parasites

    SN2012ab: A Peculiar Type IIn Supernova with Aspherical Circumstellar Material

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    We present photometry, spectra, and spectropolarimetry of supernova (SN) 2012ab, mostly obtained over the course of ∼300\sim 300 days after discovery. SN 2012ab was a Type IIn (SN IIn) event discovered near the nucleus of spiral galaxy 2MASXJ12224762+0536247. While its light curve resembles that of SN 1998S, its spectral evolution does not. We see indications of CSM interaction in the strong intermediate-width emission features, the high luminosity (peak at absolute magnitude M=−19.5M=-19.5), and the lack of broad absorption features in the spectrum. The Hα\alpha emission undergoes a peculiar transition. At early times it shows a broad blue emission wing out to −14,000-14{,}000 km s−1\mathrm{s^{-1}} and a truncated red wing. Then at late times (>> 100 \,days) it shows a truncated blue wing and a very broad red emission wing out to roughly +20,000+20{,}000 km s−1\mathrm{s^{-1}}. This late-time broad red wing probably arises in the reverse shock. Spectra also show an asymmetric intermediate-width Hα\alpha component with stronger emission on the red side at late times. The evolution of the asymmetric profiles requires a density structure in the distant CSM that is highly aspherical. Our spectropolarimetric data also suggest asphericity with a strong continuum polarization of ∼1−3\sim 1-3% and depolarization in the Hα\alpha line, indicating asphericity in the CSM at a level comparable to that in other SNe IIn. We estimate a mass-loss rate of M˙=0.050 M⊙ yr−1\dot{M} = 0.050\, {\rm M}_{\odot}\,\mathrm{yr^{-1}} for vpre=100v_{\rm pre} = 100 \,km \,s−1\mathrm{s^{-1}} extending back at least 75 \,yr prior to the SN. The strong departure from axisymmetry in the CSM of SN 2012ab may suggest that the progenitor was an eccentric binary system undergoing eruptive mass loss.Comment: 18 pages, 12 figure

    IMECE2005-81300 EVALUATION OF HEAVY TRUCK ROLLOVER CRASHWORTHINESS

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    ABSTRACT Heavy trucks (those having a gross vehicle weight rating of greater than 10,000 pounds) are an essential part of the United States economy and account for 4% of all registered vehicles. The large size and weight of these vehicles can pose a serious safety threat to the vehicle's occupants in the event of a rollover collision. The rollover crashworthiness of heavy trucks, in particular the structural integrity of the cab, is analyzed in this paper. An actual rollover accident was analyzed and the cab design of an exemplar vehicle was evaluated. Modifications were made to the exemplar and an inverted drop test onto the roof of the cab was conducted. Recommendations for improving the rollover crashworthiness of heavy trucks are provided. An analysis of heavy truck rollover accidents was also conducted for data available from 1994-2002 by submitting queries to the Fatality Analysis Reporting System (FARS), which is administered by the National Highway Safety Administration (NHTSA), in order to determine the number of incapacitating and fatal injuries that occurred when the occupants were contained in the cab during a rollover accident. The percentage of incapacitating and fatal injuries for restrained occupants was determined by analyzing the rollover data obtained from the FARS rollover query that was used and was found to be 35%. Therefore, restrained occupants in heavy trucks can sustain significant injuries during rollover accidents, in part, due to insufficient rollover crashworthiness

    teigen: An R Package for Model-Based Clustering and Classification via the Multivariate t Distribution

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    The teigen R package is introduced and utilized for model-based clustering and classification. The tEIGEN family of mixtures of multivariate t distributions is formed via an eigen-decomposition of the component covariance matrices and subsequent componentwise constraints. The teigen package implements all previously published tEIGEN family members as well as eight additional models: four multivariate and four univariate. The resulting family of 32 mixture models is implemented in both serial and parallel, with useful dedicated functions. Methodology and examples that illustrate teigen's functionality are presented
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