Cogeneration and Small Power Production: Florida\u27s Approach to Decentralized Generation

The changing economics of electricity generation in the 1970\u27s, coupled with the 1973-74 oil crisis, prompted both a legislative and societal examination of the United States\u27 approach to decentralized electricity production

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease

There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need. AD is characterized by episodic memory loss followed by severe cognitive decline and is associated with many neuropathological changes. AD is characterized by deposits of amyloid beta (A?), neurofibrillary tangles, and neuroinflammation. Active immunization or passive immunization against A? leads to the clearance of deposits in transgenic mice expressing human A?. This clearance is associated with reversal of associated cognitive deficits, but these results have not translated to humans, with both active and passive immunotherapy failing to improve memory loss. One explanation for these observations is that certain anti-A? antibodies mediate damage to the cerebral vasculature limiting the top dose and potentially reducing efficacy. Fc gamma receptors (Fc?R) are a family of immunoglobulin-like receptors which bind to the Fc portion of IgG, and mediate the response of effector cells to immune complexes. Data from both mouse and human studies suggest that cross-linking Fc?R by therapeutic antibodies and the subsequent pro-inflammatory response mediates the vascular side effects seen following immunotherapy. Increasing evidence is emerging that Fc?R expression on CNS resident cells, including microglia and neurons, is increased during aging and functionally involved in the pathogenesis of age-related neurodegenerative diseases. Therefore, we propose that increased expression and ligation of Fc?R in the CNS, either by endogenous IgG or therapeutic antibodies, has the potential to induce vascular damage and exacerbate neurodegeneration. To produce safe and effective immunotherapies for AD and other neurodegenerative diseases it will be vital to understand the role of Fc?R in the healthy and diseased brain. Here we review the literature on Fc?R expression, function and proposed roles in multiple age-related neurological diseases. Lessons can be learnt from therapeutic antibodies used for the treatment of cancer where antibodies have been engineered for optimal efficacy

The Opinion - Vol. 07, No. 08

Originally published in print for Fuller Theological Seminary\u27s community from 1962 through 1977.https://digitalcommons.fuller.edu/fts-opinion/1114/thumbnail.jp

Florida Takeover Law: Control-Share Acquisitions

Under Florida\u27s new control-share acquisition law, a shareholder\u27s right to vote will be determined in certain circumstances by a vote of the other shareholders. Merrs. [sic] Rasmussen and Fuller contend that the commerce clause precludes the law\u27s interference with interstate commerce, that the law might be preempted by the Williams Act, and that the law\u27s validity is questionable on other constitutional grounds. The authors also suggest answers to the may questions they raise regarding ambiguities in the law, and offer advice for both potential targets and stock acquirers on how to comply with the law

The Opinion - Vol. 07, No. 09

Originally published in print for Fuller Theological Seminary\u27s community from 1962 through 1977.https://digitalcommons.fuller.edu/fts-opinion/1115/thumbnail.jp

Intellectual need and problem-free activity in the mathematics classroom

Intellectual need, a key part of the DNR theoretical framework, is posited to be necessary for significant learning to occur. This paper provides a theoretical examination of intellectual need and its absence in mathematics classrooms. Although this is not an empirical study, we use data from observed high school algebra classrooms to illustrate four categories of activity students engage in while feeling little or no intellectual need. We present multiple examples for each category in order to draw out different nuances of the activity, and we contrast the observed situations with ones that would provide various types of intellectual need. Finally, we offer general suggestions for teaching with intellectual need