7,915 research outputs found
Treatment of Aspergillosis.
Infections caused by Aspergillus spp. remain associated with high morbidity and mortality. While mold-active antifungal prophylaxis has led to a decrease of occurrence of invasive aspergillosis (IA) in those patients most at risk for infection, breakthrough IA does occur and remains difficult to diagnose due to low sensitivities of mycological tests for IA. IA is also increasingly observed in other non-neutropenic patient groups, where clinical presentation is atypical and diagnosis remains challenging. Early and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals. Recent guidelines recommend voriconazole and/or isavuconazole for the primary treatment of IA, with liposomal amphotericin B being the first alternative, and posaconazole, as well as echinocandins, primarily recommended for salvage treatment. Few studies have evaluated treatment options for chronic pulmonary aspergillosis (CPA), where long-term oral itraconazole or voriconazole remain the treatment of choice
Path Puzzles: Discrete Tomography with a Path Constraint is Hard
We prove that path puzzles with complete row and column information--or
equivalently, 2D orthogonal discrete tomography with Hamiltonicity
constraint--are strongly NP-complete, ASP-complete, and #P-complete. Along the
way, we newly establish ASP-completeness and #P-completeness for 3-Dimensional
Matching and Numerical 3-Dimensional Matching.Comment: 16 pages, 8 figures. Revised proof of Theorem 2.4. 2-page abstract
appeared in Abstracts from the 20th Japan Conference on Discrete and
Computational Geometry, Graphs, and Games (JCDCGGG 2017
Number fields without small generators
Let be an integer, and let be its smallest divisor. We show
that there are infinitely many number fields of degree whose primitive
elements all have relatively large height in terms of , and the
discriminant of the number field. This provides a negative answer to a
questions of W. Ruppert from 1998 in the case when is composite.
Conditional on a very weak form of a folk conjecture about the distribution of
number fields, we negatively answer Ruppert's question for all
An ERP Study of Major-Minor Classification in Melodies
Skip to Next Section COMPOSERS COMMONLY USE MAJOR OR MINOR SCALES to create different moods in music.Nonmusicians show poor discrimination and classification of this musical dimension; however, they can perform these tasks if the decision is phrased as happy vs. sad.We created pairs of melodies identical except for mode; the first major or minor third or sixth was the critical note that distinguished major from minor mode. Musicians and nonmusicians judged each melody as major vs. minor or happy vs. sad.We collected ERP waveforms, triggered to the onset of the critical note. Musicians showed a late positive component (P3) to the critical note only for the minor melodies, and in both tasks.Nonmusicians could adequately classify the melodies as happy or sad but showed little evidence of processing the critical information. Major appears to be the default mode in music, and musicians and nonmusicians apparently process mode differently
Comparison of Visual Analog Pain Score Reported to Physician vs Nurse in Nonoperatively Treated Foot and Ankle Patients
Background: Patient reported outcome measures (PROMs) are taking a more prominent role in Orthopedics as health care seeks to define treatment outcomes. The Visual Analogue Scale (VAS) is considered a reliable measure of acute pain. A previous study found that operative candidates’ VAS pain score was significantly higher when reported to the surgeon compared to the nurse. This study’s aim is to examine whether this phenomenon occurs in nonoperative patients. We hypothesize that patients’ VAS scores reported to the surgeon and a nurse will be the same
Methods: This study is a retrospective cohort of 201 consecutive nonoperative patients treated by a single surgeon. Patients were asked to rate pain intensity by a nurse followed by the surgeon using a horizontal VAS, 0 “no pain” to 10 worst pain”. Differences in reported pain levels were compared with data from the previous cohort of 201 consecutive operative patients.
Results: The mean VAS score reported to the nurse was 3.2 whereas the mean VAS score reported to the surgeon was 4.2 (p\u3c.001). The mean difference in VAS scores reported for operative patients was 2.9, whereas the mean difference for nonoperative patients was 1.0 (p \u3c .001).
Conclusion: This study found statistically significant differences between VAS scores reported to the surgeon versus the nurse in nonoperative patients which support the trend found in our previous study, where operative patients reported significantly higher scores to the surgeon. The mean difference between reported pain scores is significantly higher for operative patients compared to nonoperative patients
Ideology and the Study of Judicial Behavior
http://deepblue.lib.umich.edu/bitstream/2027.42/116253/1/IdPsychLaw.pd
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