Political efficacy and participation in twenty-seven democracies: how electoral systems shape political behaviour

© 2008 Cambridge University PressAdvocates of proportional representation (PR) often cite its potential for increasing citizen involvement in politics as one of PR's fundamental advantages over plurality or first-past-the-post systems. The assumption is that plurality electoral systems distort the translation of votes into seats, discouraging and alienating small party supporters and other political minorities. In contrast, PR systems are believed to provide greater opportunities for representation which are assumed to instil greater efficacy and increase participation. We examine this theory linking institutions to electoral participation across a diverse set of countries using data from the Comparative Study of Electoral Systems. Using a multi-level approach we find evidence consistent with the expectations about the negative influence of disproportional systems on political minorities. Voters are also likely to have stronger partisan preferences in PR systems, which enhances political efficacy and increases voter participation. The effects of PR, however, are not all positive; broad coalitions, which are likely to be a feature of these systems, reduce political efficacy

How elections change the way citizens view the political system: campaigns, media effects and electoral outcomes in comparative perspective

© 2003 Cambridge University PressAttitudes towards the political system have often been assumed to be stable attributes that are not easily influenced by short-term forces. We examine the extent to which attention to media coverage, campaign activity and electoral outcomes can mobilize support for the political system in the context of an election campaign. Using pre-election and post-election survey panels from the United States, Britain and New Zealand, we find only small shifts in aggregate measures of system support. However, we find that there are significant shifts in system support at the individual level that can be explained by status as election winners, attention to the media, particularly serious news coverage and economic perceptions. The results have implications for the debate over measures of system support such as trust, cynicism and efficacy.EU Fifth Framework Programme; Netherlands Organisation for Scientific Researc

Getting out the vote: party mobilization in a comparative perspective

© 2007 Cambridge University PressA long tradition within political science examines the impact of party canvassing on voter participation. Very little of this work, however, is comparative in scope. This essay examines how system-level characteristics shape the nature and impact of party canvassing and how voters respond to those efforts. Parties are found to target the same types of potential voters everywhere – those who are likely to participate. However, one important difference is that overall levels of party contact are far greater in candidate-based systems than in proportional representation (PR) systems. Party mobilization, therefore, cannot explain the higher rates of turnout observed in PR systems

Electoral Systems and Government Arrangements:Preferences of Parliamentary Candidates in Germany, the Netherlands and New Zealand

We examine elite support for electoral arrangements in Germany and New Zealand. Both countries share a mixed electoral system (MMP) that combines single member districts with proportional representation. New Zealand's experience with MMP is relatively brief, having held just three elections since 1996 while Germany's experience dates back to the 1950s. Using data collected through surveys of parliamentary candidates we consider how various factors such as partisan self-interest, minority status, incumbency, ideology, and attitudes about candidate selection structure support for the electoral system. We find strong overall support for MMP in both countries, with small parties and those to the left of the ideological spectrum being most supportive of the system. Those who are dissatisfied with MMP are likely to be those dissatisfied with the candidate selection process or those in the opposition

Mega-gifts in American Philanthropy: General & Jewish Giving Patterns Between 1995-2000

The researchers collected data on gifts of $10 million or above in order to compile this report. From this set, they identified gifts from Jewish philanthropists and offer some conclusions about the nature of high-end giving. Among other findings, the authors note that the largest number of gifts, by far, went to private educational institutions, and among Jewish donors, arts and culture was the second most popular recipient group. A listing of the donations is included in the appendices. With bibliographic references

Voters and coalition governments

a b s t r a c t Coalition governments are the norm in parliamentary democracies. Yet, despite the predominance of this type of government, political scientists have only recently started to investigate how voters approach elections when a coalition government is the likely outcome. Such elections present additional uncertainty and complexity for voters compared with elections in plurality systems, where party choice translates more directly into a choice of government. These factors have lead to the assumption that strategic voting is unlikely to occur in systems that produce coalition governments. In this introductory article to the special issue on Voters and Coalition Governments, we consider whether voters have the capacity to anticipate specific coalition outcomes and propose a framework for understanding the conditions that lead to strategic voting in both plurality and proportional systems

Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of MSC immunomodulatory function. This effect depends on signaling through the glucocorticoid receptor and is mediated through up-regulation of FOXO3. Treatment of MSCs with glucocorticoids, budesonide or dexamethasone, enhanced IDO expression following IFN-γ stimulation in multiple donors and was able to restore IDO expression in over-passaged MSCs. As IDO enhancement was most notable when cells were continuously exposed to budesonide, we engineered MSC with budesonide loaded PLGA microparticles. MSC efficiently internalized budesonide microparticles and exhibited 4-fold enhanced IDO activity compared to budesonide preconditioned and naïve MSC, resulting in a 2-fold improvement in suppression of stimulated peripheral blood mononuclear cells in an IDO-dependent manner. Thus, the augmentation of MSC immune modulation may abrogate challenges associated with inadequate potency and enhance their therapeutic efficacy

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

Myeloid cells are a feature of most tissues. Here we show that during development, retinal myeloid cells (RMCs) produce Wnt ligands to regulate blood vessel branching. In the mouse retina, where angiogenesis occurs postnatally, somatic deletion in RMCs of the Wnt ligand transporter Wntless results in increased angiogenesis in the deeper layers. We also show that mutation of Wnt5a and Wnt11 results in increased angiogenesis and that these ligands elicit RMC responses via a non-canonical Wnt pathway. Using cultured myeloid-like cells and RMC somatic deletion of Flt1, we show that an effector of Wnt-dependent suppression of angiogenesis by RMCs is Flt1, a naturally occurring inhibitor of vascular endothelial growth factor (VEGF). These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Targeting drugs selectively to the inflamed intestine may improve therapeutic outcomes and minimize systemic toxicity. We report the development of an inflammation-targeting hydrogel (IT-hydrogel) that acts as a drug delivery system to the inflamed colon. Hydrogel microfibers were generated from ascorbyl palmitate, an amphiphile that is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration. IT-hydrogel microfibers loaded with the anti-inflammatory corticosteroid dexamethasone (Dex) were stable, released drug only upon enzymatic digestion, and demonstrated preferential adhesion to inflamed epithelial surfaces in vitro and in two mouse colitis models in vivo. Dex-loaded IT-hydrogel enemas, but not free Dex enemas, administered every other day to mice with colitis resulted in a significant reduction in inflammation and were associated with lower Dex peak serum concentrations and, thus, less systemic drug exposure. Ex vivo analysis of colon tissue samples from patients with ulcerative colitis demonstrated that IT-hydrogel microfibers adhered preferentially to mucosa from inflamed lesions compared with histologically normal sites. The IT-hydrogel drug delivery platform represents a promising approach for targeted enema-based therapies in patients with colonic IBD