Application of Computable General Equilibrium Model to Derive Impacts of Surface Water Reallocation Policy

Resource /Energy Economics and Policy,

Bioresorbable Polylactide Interbody Implants in an Ovine Anterior Cervical Discectomy and Fusion Model: Three-Year Results

Study Design. In vivo study of anterior discectomy and fusion using a bioresorbable 70:30 poly(l-lactide-co-d,l-lactide) interbody implant in an ovine model. Objective. To evaluate the efficacy of the polylactide implant to function as an interbody fusion device, and to assess the tissue reaction to the material during the resorption process. Summary of Background Data. The use of polylactide as a cervical interbody implant has several potential advantages when compared with traditional materials. Having an elastic modulus very similar to bone minimizes the potential for stress shielding, and as the material resorbs additional loading is transferred to the developing fusion mass. Although preclinical and clinical studies have demonstrated the suitability of polylactide implants for lumbar interbody fusion, detailed information on cervical anterior cervical discectomy and fusion (ACDF) with polylactide devices is desirable. Methods. Single level ACDF was performed in 8 skeletally mature ewes. Bioresorbable 70:30 poly (l-lactide-co-d,l-lactide) interbody implants packed with autograft were used with single-level metallic plates. Radiographs were made every 3 months up to 1 year, and yearly thereafter. The animals were killed at 6 months (3 animals), 12 months (3 animals), and 36 months (2 animals). In addition to the serial plain radiographs, the specimens were evaluated by nondestructive biomechanical testing and undecalcified histologic analysis. Results. The bioresorbable polylactide implants were effective in achieving interbody fusion. The 6-month animals appeared fused radiographically and biomechanically, whereas histologic sections demonstrated partial fusion (in 3 of 3 animals). Radiographic fusion was confirmed histologically and biomechanically at 12 months (3 of 3 animals) and 36 months (2 of 2 animals). A mild chronic inflammatory response to the resorbing polylactide implant was observed at both 6 months and 12 months. At 36 months, the operative levels were solidly fused and the implants were completely resorbed. No adverse tissue response was observed in any animal at any time period. Conclusion. Interbody fusion was achieved using bioresorbable polylactide implants, with no evidence of implant collapse, extrusion, or adverse tissue response to the material. The use of polylactide as a cervical interbody device appears both safe and effective based on these ACDF animal model results

Sediment dynamics in the Adriatic Sea investigated with coupled models

Several large research programs focused on the Adriatic Sea in winter 2002-2003, making it an exciting place for sediment dynamics modelers (Figure 1). Investigations of atmospheric forcing and oceanic response (including wave generation and propagation, water-mass formation, stratification, and circulation), suspended material, bottom boundary layer dynamics, bottom sediment, and small-scale stratigraphy were performed by European and North American researchers participating in several projects. The goal of EuroSTRATAFORM researchers is to improve our ability to understand and simulate the physical processes that deliver sediment to the marine environment and generate stratigraphic signatures. Scientists involved in the Po and Apennine Sediment Transport and Accumulation (PASTA) experiment benefited from other major research programs including ACE (Adriatic Circulation Experiment), DOLCE VITA (Dynamics of Localized Currents and Eddy Variability in the Adriatic), EACE (the Croatian East Adriatic Circulation Experiment project), WISE (West Istria Experiment), and ADRICOSM (Italian nowcasting and forecasting) studies

Household Monthly Alcohol Purchases After Washington\u27s Privatization of Liquor

Thirteen states limit alcohol purchases to state-run stores. Washington was among these states until 2011, when voters passed Initiative 1183, which privatized liquor sales and imposed taxes and fees on them. As a result, the number of retail sites increased dramatically, and the cost of liquor went up. The authors compared the amount of alcohol purchased by households in Washington metropolitan areas to the amount purchased by households in 10 states that retained monopoly control of alcohol sales, before and after privatization

Beam Tests of Ionization Chambers for the NuMI Neutrino Beam

We have conducted tests at the Fermilab Booster of ionization chambers to be used as monitors of the NuMI neutrino beamline. The chambers were exposed to proton fluxes of up to 10$^{12}$ particles/cm$^2$/1.56$\mu$s. We studied space charge effects which can reduce signal collection from the chambers at large charged particle beam intensities.Comment: submitted to IEEE Trans Nucl. Sc