700 research outputs found
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
High-frequency cortical activity, particularly in the 250â600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (4100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100â250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy
Bayesian Analysis of Two Stellar Populations in Galactic Globular Clusters II: NGC 5024, NGC 5272, and NGC 6352
We use Cycle 21 Hubble Space Telescope (HST) observations and HST archival
ACS Treasury observations of Galactic Globular Clusters to find and
characterize two stellar populations in NGC 5024 (M53), NGC 5272 (M3), and NGC
6352. For these three clusters, both single and double-population analyses are
used to determine a best fit isochrone(s). We employ a sophisticated Bayesian
analysis technique to simultaneously fit the cluster parameters (age, distance,
absorption, and metallicity) that characterize each cluster. For the
two-population analysis, unique population level helium values are also fit to
each distinct population of the cluster and the relative proportions of the
populations are determined. We find differences in helium ranging from
0.05 to 0.11 for these three clusters. Model grids with solar
-element abundances ([/Fe] =0.0) and enhanced -elements
([/Fe]=0.4) are adopted.Comment: ApJ, 21 pages, 14 figures, 7 table
An m sin i = 24 Earth Mass Planetary Companion To The Nearby M Dwarf GJ 176
We report the detection of a planetary companion with a minimum mass of m sin
i = 0.0771 M_Jup = 24.5 M_Earth to the nearby (d = 9.4 pc) M2.5V star GJ 176.
The star was observed as part of our M dwarf planet search at the Hobby-Eberly
Telescope (HET). The detection is based on 5 years of high-precision
differential radial velocity (RV) measurements using the
High-Resolution-Spectrograph (HRS). The orbital period of the planet is 10.24
d. GJ 176 thus joins the small (but increasing) sample of M dwarfs hosting
short-periodic planets with minimum masses in the Neptune-mass range. Low mass
planets could be relatively common around M dwarfs and the current detections
might represent the tip of a rocky planet population.Comment: 13 pages preprint, 3 figures, submitted to Ap
Interferometric Astrometry of Proxima Centauri and Barnard's Star Using Hubble Space Telescope Fine Guidance Sensor 3: Detection Limits for sub-Stellar Companions
We report on a sub-stellar companion search utilizing interferometric
fringe-tracking astrometry acquired with Fine Guidance Sensor 3 (FGS 3) on the
Hubble Space Telescope. Our targets were Proxima Centauri and Barnard's Star.
We obtain absolute parallax values for Proxima Cen pi_{abs} = 0.7687 arcsecond
and for Barnard's Star pi_{abs} = 0.5454 arcsecond.
Once low-amplitude instrumental systematic errors are identified and removed,
our companion detection sensitivity is less than or equal to one Jupiter mass
for periods longer than 60 days for Proxima Cen. Between the astrometry and the
radial velocity results we exclude all companions with M > 0.8M_{Jup} for the
range of periods 1 < P < 1000 days. For Barnard's Star our companion detection
sensitivity is less than or equal to one Jupiter mass for periods long er than
150 days. Our null results for Barnard's Star are consistent with those of
Gatewood (1995).Comment: 35 pages, 13 figures, to appear in August 1999 A
Bayesian model comparison applied to the Explorer-Nautilus 2001 coincidence data
Bayesian reasoning is applied to the data by the ROG Collaboration, in which
gravitational wave (g.w.) signals are searched for in a coincidence experiment
between Explorer and Nautilus. The use of Bayesian reasoning allows, under well
defined hypotheses, even tiny pieces of evidence in favor of each model to be
extracted from the data. The combination of the data of several experiments can
therefore be performed in an optimal and efficient way. Some models for
Galactic sources are considered and, within each model, the experimental result
is summarized with the likelihood rescaled to the insensitivity limit value
(`` function''). The model comparison result is given in in terms of
Bayes factors, which quantify how the ratio of beliefs about two alternative
models are modified by the experimental observationComment: 16 pages, 4 figures. Presented at the GWDAW2002 conference, held in
Kyoto on Dec.,2002. This version includes comments by the referees of CQG,
which has accepted the paper for pubblication in the special issue of the
conference. In particular, note that in Eq. 12 there was a typeset error. As
suggested by one of the referees, a uniform prior in Log(alpha) has also been
considere
High-Frequency network activity, global increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures In Vitro
How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. Here we demonstrate the existence, in the hippocampal CA1 region, of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) (100 Hz) and reduction in system complexity.HFAis generated by the firing of neurons, mainly pyramidal cells, at much lower frequencies. Individual cycles ofHFAare generated by the near-synchronous (within 5 ms) firing of small numbers of pyramidal cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization; the presence of very similar HFA in the high-potassium model shows that it does not depend on an absence of synaptic transmission. Immediately before seizure onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing perturbations can trigger seizures. Transition to seizure is haracterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure
Recommended from our members
Psychopathology in Williams syndrome: the effect of individual differences across the lifespan
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability. The parents of 50 participants with WS, aged 6-50 years, were interviewed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS-PL). The prevalence of a wide range of Axis I DSM-IV disorders was assessed. In addition to high rates of anxiety and Attention Deficit Hyperactivity Disorder (ADHD) (38% and 20% respectively), 14% of our sample met criteria for a depressive disorder and 42% of participants were not experiencing any significant psychopathological difficulties. There was some evidence for different patterns of psychopathology between children and adults with WS and between males and females. These relationships were largely in keeping with those found in the typically developing population, thus supporting the validity of applying theory and treatment approaches for psychopathology in the typically developing population to WS
Photometry of Proxima Centauri and Barnard's Star Using HST Fine Guidance Sensor 3: A Search for Periodic Variations
We have observed Proxima Centauri and Barnard's Star with Hubble Space
Telescope Fine Guidance Sensor 3. Proxima Centauri exhibits small-amplitude,
periodic photometric variations. Once several sources of systematic photometric
error are corrected, we obtain 2 milli-magnitude internal photometric
precision. We identify two distinct behavior modes over the past four years:
higher amplitude, longer period; smaller amplitude, shorter period. Within the
errors one period (P ~ 83d) is twice the other. Barnard's Star shows very weak
evidence for periodicity on a timescale of approximately 130 days. If we
interpret these periodic phenomena as rotational modulation of star spots, we
identify three discrete spots on Proxima Cen and possibly one spot on Barnard's
Star. We find that the disturbances change significantly on time scales as
short as one rotation period.Comment: 39 pages, 17 figure
- âŠ