How to Perform Umbilical Cord Arterial and Venous Blood Sampling in Neonatal Foals

Umbilical cord arterial and venous blood gas analysis is a commonly performed procedure in human neonatal medicine to help ascertain a newborn infant’s oxygenation and acid-base status prior to birth. Defined protocols for performing the procedure have been described in the medical literature. The aim of this report was to describe in detail the procedure for collecting paired blood samples from the umbilical artery and vein in newborn foals so that stall-side blood gas analysis could be carried out. Thirty-five Thoroughbred foals >320 days gestation from mares at one stud farm were sampled. Paired umbilical arterial and venous whole-blood samples were obtained in n=30 foals, umbilical artery only samples obtained in n=3 and umbilical vein only samples obtained in n=2 foals. There were no adverse events or clinical outcomes associated with the sampling protocol described. The authors found that umbilical cord blood collection for blood gas analysis was a practical clinical technique that potentially could be used as a stall-side method for assessing the in utero oxygenation and acid-base status of newborn foals

Optimization and analysis of frequencies of multi-scale graphene/fibre reinforced nanocomposite laminates with non-uniform distributions of reinforcements

Optimal design and analysis of three-phase graphene/fibre reinforced laminated nanocomposite plates with respect to maximizing the fundamental frequency is the subject of the present study. Optimal design solutions are given for four different sets of design parameters. First design problem determines the optimal graphene contents of individual layers, the second one both graphene and fibre contents, the third optimizes the graphene and fibre contents as well as the layer thicknesses of individual layers, and the fourth problem optimizes the graphene and fibre contents, layer thicknesses and fibre orientations. Purpose of this approach is to assess and compare different levels of optimization by means of a design efficiency index and as such to determine the effectiveness of different design parameters in maximizing the fundamental frequency. Optimization is implemented using a Sequential Quadratic Programming algorithm and the mechanical properties of graphene/fibre nanocomposite are determined via micromechanical relations. Vibration analysis is conducted by the finite element method using four-noded Mindlin plate elements. Results are obtained for simply supported (SSSS), clamped (CCCC) and simply supported-clamped boundary conditions for opposite edges (SCSC). It is observed that non-uniform distributions of graphene and fibre as well as fibre orientations are quite effective in improving the design efficiency