Collective Effects in the CLIC Damping Rings

Possible performance limitations coming fromcollective effects in the CLIC damping rings are the subject of this paper. In particular, the consequences of space charge, due to the very high beam brilliance, and of the resistive wall impedance, due to the locally very small beam pipe, are considered potentially dangerous in spite of the high beam energy. Space charge has been studied in detail with the HEADTAIL code, which was modified in order to take into account a finer lattice structure. This study also includes requirements on the broad band impedance of the damping rings and ion effects in the electron ring (electron cloud in the positron ring is treated in a companion paper). Its goal is to identify all the potential design constraints determined by these phenomena

Kinetic Inductance of Josephson Junction Arrays: Dynamic and Equilibrium Calculations

We show analytically that the inverse kinetic inductance $L^{-1}$ of an overdamped junction array at low frequencies is proportional to the admittance of an inhomogeneous equivalent impedance network. The $ij^{th}$ bond in this equivalent network has an inverse inductance $J_{ij}\cos(\theta_i^0-\theta_j^0-A_{ij})$, where $J_{ij}$ is the Josephson coupling energy of the $ij^{th}$ bond, $\theta_i^0$ is the ground-state phase of the grain $i$, and $A_{ij}$ is the usual magnetic phase factor. We use this theorem to calculate $L^{-1}$ for square arrays as large as $180\times 180$. The calculated $L^{-1}$ is in very good agreement with the low-temperature limit of the helicity modulus $\gamma$ calculated by conventional equilibrium Monte Carlo techniques. However, the finite temperature structure of $\gamma$, as a function of magnetic field, is \underline{sharper} than the zero-temperature $L^{-1}$, which shows surprisingly weak structure. In triangular arrays, the equilibrium calculation of $\gamma$ yields a series of peaks at frustrations $f = \frac{1}{2}(1-1/N)$, where $N$ is an integer $\geq 2$, consistent with experiment.Comment: 14 pages + 6 postscript figures, 3.0 REVTe

Vortex phase transformations probed by the local ac response of Bi_{2}Sr_{2}CaCu_{2}O_{8+\delta} single crystals with various doping

The linear ac response of the vortex system is measured locally in Bi-2212 single crystals at various doping, using a miniature two-coil mutual-inductance technique. It was found that a step-like change in the local ac response takes place exactly at the first-order transition (FOT) temperature T_{FOT}(H) determined by a global dc magnetization measurement. The T_{FOT}(H) line in the H-T phase diagram becomes steeper with increasing doping. In the higher-field region where the FOT is not observed, the local ac response still shows a broadened but distinct feature, which can be interpreted to mark the growth of a short-range order in the vortex system.Comment: 4 pages, including 5 eps figure

Dynamical aperture studies for the CERN LHC: comparison between statistical assignment of magnetic field errors and actual measured field errors

It is customary to evaluate the performance of a circular particle accelerator by computing the dynamical aperture, i.e. the domain in phase space where bounded singleparticle motion occurs. In the case of the LHC the dynamical aperture computation is performed by assuming a statistical distribution of the magnetic field errors of various magnets classes: the numerical computations are repeated for a given set of realisations of the LHC ring. With the progress in the magnet production and allocation of the available positions in the ring, the statistical approach has to be replaced by the computation of one single configuration, namely the actual realisation of the machine. Comparisons between the two approaches are presented and discussed in details.Â

Measuring farmland biodiversity

About one-third of the world’s land surface is used for farming, a fact that bears important implications for biodiversity. In Europe, for instance, an estimated 50 percent of all wild species are reliant on agricultural habitats, while agricultural productivity often depends on the presence or absence of particular species. Despite this close coupling, surprisingly little is known about the status and evolution of farmland biodiversity. A team of European and African researchers, hoping to fill this gap in information, recently invented and piloted a new toolbox called the BioBio indicator set, which measures 23 different instances of biodiversity across a variety of farm types and scales in Europe. Applications were also tested in Tunisia, Ukraine, and Uganda, where they proved a feasible starting point for adaptation to the agricultural context of different countries

Discrete charging of metallic grains: Statistics of addition spectra

We analyze the statistics of electrostatic energies (and their differences) for a quantum dot system composed of a finite number $K$ of electron islands (metallic grains) with random capacitance-inductance matrix $C$, for which the total charge is discrete, $Q=Ne$ (where $e$ is the charge of an electron and $N$ is an integer). The analysis is based on a generalized charging model, where the electrons are distributed among the grains such that the electrostatic energy E(N) is minimal. Its second difference (inverse compressibility) $\chi_{N}=E(N+1)-2 E(N)+E(N-1)$ represents the spacing between adjacent Coulomb blockade peaks appearing when the conductance of the quantum dot is plotted against gate voltage. The statistics of this quantity has been the focus of experimental and theoretical investigations during the last two decades. We provide an algorithm for calculating the distribution function corresponding to $\chi_{N}$ and show that this function is piecewise polynomial.Comment: 21 pages, no figures, mathematical nomenclature (except for Abstract and Introduction

Measuring Farmland Biodiversity

Despite close interaction between agriculture and biodiversity—farms cover one-third of the world’s land surface—little is empirically known about the ecological effects of different farming practices. About one-third of the world’s land surface is used for farming, a fact that bears important implications for biodiversity. In Europe, for instance, an estimated 50 percent of all wild species are reliant on agricultural habitats, while agricultural productivity often depends on the presence or absence of particular species. Despite this close coupling, surprisingly little is known about the status and evolution of farmland biodiversity. A team of European and African researchers, hoping to fill this gap in information, recently invented and piloted a new toolbox called the BioBio indicator set, which measures 23 different instances of biodiversity across a variety of farm types and scales in Europe. Applications were also tested in Tunisia, Ukraine, and Uganda, where they proved a feasible starting point for adaptation to the agricultural context of different countrie

Low temperature superfluid stiffness of d-wave superconductor in a magnetic field

The temperature and field dependence of the superfluid density $\rho_s$ in the vortex state of a d-wave superconductor are calculated using a microscopic model in the quasiclassical approximation. We show that at temperatures below T^{*} \varpropto \sqrt{H}$, the linear T dependence of rho_s crosses over to a T^2 dependence differently from the behavior of the effective penetration depth, lambda_eff^{-2}(T). We point out that the expected dependences could be probed by a mutual-inductance technique experiment.Comment: 4 pages, RevTeX4, 2 EPS figures; minor revisions made and 1 new reference added; final version published in PR

Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis.

The endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for therapeutic intervention in human diseases. Endothelin-receptor antagonists are in clinical use to treat pulmonary arterial hypertension and have been under clinical investigation for the treatment of several other diseases, such as systemic hypertension, cancer, vasospasm, and fibrogenic diseases. In this Perspective, we review the molecules that have been evaluated in human clinical trials for the treatment of pulmonary arterial hypertension, as well as other cardiovascular diseases, cancer, and fibrosis. We will also discuss the therapeutic consequences of receptor selectivity with regard to ETA-selective, ETB-selective, or dual ETA/ETB antagonists. We will also consider which chemical characteristics are relevant to clinical use and the properties of molecules necessary for efficacy in treating diseases against which known molecules displayed suboptimal efficacy