143 research outputs found
Le dĂ©pĂŽt de lâĂąge du Bronze moyen de Keravel en Lannilis (FinistĂšre)
Le dĂ©pĂŽt du Bronze moyen de Keravel en Lannilis (FinistĂšre) fut mis au jour lors dâune opĂ©ration de diagnostic archĂ©ologique en 2007. Une dizaine dâobjets ou fragments dâobjets fut dĂ©couverte, probable reflet dâun dĂ©pĂŽt partiellement dĂ©truit par une petite carriĂšre dâarĂšne granitique, creusĂ©e Ă une Ă©poque indĂ©terminĂ©e. Une pointe de lance dĂ©corĂ©e et des fragments de haches Ă talon ou Ă rebord se rattachent au groupe typologique de TrĂ©boul. Ils sont accompagnĂ©s de fragments dâune grande hache de type breton. Lâensemble, datable du xve siĂšcle avant J.-C., sâinsĂšre dans un Ă©tat des connaissances, dĂ©jĂ richement documentĂ© en Bretagne, Ă propos de ce type de dĂ©pĂŽts.The Middle Bronze Age Keravel hoard, Lannilis (FinistĂšre), was discovered during an archaeological evaluation in 2007. The small assemblage of objects or fragments uncovered is probably reminiscent of a larger hoard partially destroyed by a small disused granite gravel quarry of uncertain date. A decorated spear head and some palstave or flanged-axe fragments are attributed to the Treboul Group. Fragments of a large Breton Type palstave were also present. The assemblage dates from 15th century BC and adds new material to this already well documented hoard type in Brittany
Un Ă©tablissement agricole et artisanal de la fin du haut Moyen Ăge au 22 de la rue Bourg-les-Bourgs Ă Quimper (FinistĂšre)
Une opĂ©ration de fouille prĂ©ventive rĂ©alisĂ©e rue Bourg-les-Bourgs Ă Quimper, dans un contexte antique bien connu, met au jour les structures inĂ©dites dâun petit Ă©tablissement rural datĂ© de la fin du haut Moyen Ăge, entre le ixe et le milieu du xie siĂšcle. Celui-ci, apprĂ©hendĂ© partiellement par lâemprise des fouilles, se caractĂ©rise par la prĂ©sence de fossĂ©s dâenclos, de structures de stockage et de combustion, ainsi que de fosses aux fonctions diverses. Parmi ces vestiges, se distingue un secteur artisanal stratifiĂ© dĂ©diĂ© Ă la mĂ©tallurgie (activitĂ©s de rĂ©duction de fer). Lâanalyse des structures, alliĂ©e Ă lâĂ©tude cĂ©ramique, permet de dĂ©finir lâĂ©volution chronologique et spatiale de lâĂ©tablissement. Ce dernier peut ĂȘtre mis en relation avec des sites contemporains situĂ©s autour du bassin de lâOdet et sâintĂ©grer Ă lâHistoire quimpĂ©roise.Excavations in advance of development at rue Bourg-les-Bourgs, Quimper, in the heart of the Roman settlement, revealed for the first time the remains of a small rural site dating, from the early medieval period, between the 9th and the middle of the 11th century. The settlement, only partially excavated, is defined by enclosure ditches, storage pits and also pits of varied usage. Other features were identified as corn-drying kiln, earth or oven and furnace. Among these features, an area for iron smelting was identified. Combined analysis of the features and the pottery assemblage allow the spatial and chronological evolution of the settlement to be defined. The settlement can be compared to contemporaneous sites located in the Odet basin and will take its place in the history of Quimper. (Trad. J.-Y. Robic
Pseudovasculitis and corticosteroid therapy
Pseudovasculitis, vasculitis-like syndromes, vasculitis look-alikes, or mimics of vasculitis represent a heterogeneous collection of disorders that are capable of simulating vasculitis. Inappropriate diagnosis leads to delay or absence of proper management and exposure to potentially deleterious treatment modalities such as corticosteroids and cytotoxic agents. We report the case of fibromuscular dysplasia suspected to be a polyarteritis nodosa. The progression of the lesions visualized by the ultrasonographic study and computed tomography (CT) scan after 10days of treatment led to an emergency laparotomy. The possible deleterious role of steroids given to treat the suspected vasculitis is discusse
Quimper â 7 rue Anatole-France, Parc-ar-Groas
Un projet immobilier, inclus dans le jardin situĂ© 7 rue Anatole-France, a entraĂźnĂ© la rĂ©alisation dâune fouille dâĂ©valuation sur une superficie dâenviron 100 m2 au cĆur de lâenceinte du sanctuaire de Parc-ar-Groas, sur le sommet du Mont-Frugy. LâĂ©rosion anthropique, provoquĂ©e successivement par des travaux agricoles, des entraĂźnements militaires puis des activitĂ©s de jardinage, avait dĂ©truit les sols du sanctuaire antique avant lâintervention des archĂ©ologues. Peut-ĂȘtre certains des travaux d..
Quimper â Place Laennec
Le rĂ©amĂ©nagement complet des places Saint-Corentin et Laennec, au cĆur de la citĂ© Ă©piscopale de Quimper, a entraĂźnĂ© la rĂ©alisation dâune importante fouille de sauvetage au cours du premier semestre de lâannĂ©e 1998. LâopĂ©ration de diagnostic conduite en 1996 avait dĂ©celĂ©, Ă faible profondeur, des vestiges de sols empierrĂ©s, dâesplanades recouvrant des cimetiĂšres mĂ©diĂ©vaux en excellent Ă©tat de conservation. Un projet cohĂ©rent de fouille archĂ©ologique fut montĂ© afin dâĂ©tudier minutieusement les ..
Are Boreal Ovenbirds, Seiurus aurocapilla, More Prone to Move across Inhospitable Landscapes in Alberta's Boreal Mixedwood Forest than in Southern Québec's Temperate Deciduous Forest?
Method to calibrate fission chambers in Campbelling mode
Fission chambers are neutron detectors which are widely used to instrument experimental reactors such as material testing reactors or zero power reactors. In the presence of a high level mixed gamma and neutron flux, fission chambers can be operated in Campbelling mode (also known as 'fluctuation mode' or 'mean square voltage mode') to provide reliable and precise neutron related measurements. Fission chamber calibration in Campbelling mode (in terms of neutron flux) is usually done empirically using a calibrated reference detector. A major drawback of this method is that calibration measurements have to be performed in a neutron environment very similar to the one in which the calibrated detector will be used afterwards. What we propose here is a different approach based on characterizing the fission chamber response in terms of fission rate. This way, the detector calibration coefficient is independent from the neutron spectrum and can be determined prior to the experiment. The fissile deposit response to the neutron spectrum can then be assessed independently by other means (experimental or numerical). In this paper, the response of CEA made miniature fission chambers in Campbelling mode is studied. We use a theoretical model of the signal to calculate the calibration coefficient. Input parameters of the model come from statistical distribution of individual pulses. Supporting measurements have been made in the CEA Cadarache zero power reactor MINERVE. Results are compared to an empirical Campbelling mode calibration
RĂ©habilitation de la capacitĂ© dâĂ©vacuation des crues â intĂ©gration de "PK-Weirs" sur des barrages existants
La rĂ©habilitation des barrages existants impose gĂ©nĂ©ralement une augmentation de leur capacitĂ© dâĂ©vacuation en crue. Dans de nombreuses situations, le PK-Weir (Piano Key Weir) offre Ă cet Ă©gard une solution compacte et efficace. La conception et la rĂ©alisation de tels ouvrages reprĂ©sentent un dĂ©fi pour lâingĂ©nieur, en raison de la multiplicitĂ© des conditions locales rencontrĂ©es. Cette problĂ©matique est illustrĂ©e par la prĂ©sentation de deux cas rĂ©els oĂč les questions relatives Ă la dĂ©bitance et Ă la dissipation dâĂ©nergie sont examinĂ©es. Les exemples des barrages de Saint-Marc et de Gloriettes illustrent Ă©galement lâimportance des ouvrages de dissipation dâĂ©nergie Ă lâaval du PK-Weir, dont le poids, en termes de coĂ»t ou de contrainte de projet, devient prĂ©pondĂ©rant. The rehabilitation of existing dams often requires an increase of the hydraulic capacity of the spillway. In this context, the PK-Weir (Piano Key Weir) offers a compact and efficient solution. Due to the high variety of local conditions, the design and the construction of such structures is a challenge for engineers. This problematic is illustrated by two case studies, where the flood evacuation capacity of the spillway and the energy dissipation structures have been analyzed. Regarding construction constraints and costs, the examples of St-Marcâs and Gloriettes dams reveal the importance of the energy dissipation structures, which become dominant compared to the cost of the PK-Weir itself
Lycopene Modulates THP1 and Caco2 Cells Inflammatory State through Transcriptional and Nontranscriptional Processes
Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)
Introduction: Patient-Reported Outcomes (PRO) integrate a wide range of holistic dimensions that arenot captured within clinical outcomes. Particularly, from induction treatment to maintenance therapy, patient quality-of-life (QoL) of kidney transplant recipients have been sparsely investigated in international settings.Methods: In a prospective, multi-centric cohort study, including nine transplant centers in four countries, we explored the QoL during the year following transplantation using validated elicitation instruments (EQ-5D-3L index with VAS) in a population of kidney transplant patients receiving immunosuppressive therapies. Calcineurin inhibitors (tacrolimus and ciclosporin), IMPD inhibitor (mycophenolate mofetil), and mTOR inhibitors (everolimus and sirolimus) were the standard-of-care (SOC) medications, together with tapering glucocorticoid therapy. We used EQ-5D and VAS data as QoL measures alongside descriptive statistics at inclusion, per country and hospital center. We computed the proportions of patients with different immunosuppressive therapy patterns, and using bivariate and multivariate analyses, assessed the variations of EQ-5D and VAS between baseline (i.e., inclusion Month 0) and follow up visits (Month 12).Results: Among 542 kidney transplant patients included and followed from November 2018 to June 2021, 491 filled at least one QoL questionnaire at least at baseline (Month 0). The majority of patients in all countries received tacrolimus and mycophenolate mofetil, ranging from 90.0% in Switzerland and Spain to 95.8% in Germany. At M12, a significant proportion of patients switched immunosuppressive drugs, with proportion varying from 20% in Germany to 40% in Spain and Switzerland. At visit M12, patients who kept SOC therapy had higher EQ-5D (by 8 percentage points, p < 0.05) and VAS (by 4 percentage points, p < 0.1) scores than switchers. VAS scores were generally lower than EQ-5D (mean 0.68 [0.5â0.8] vs. 0.85 [0.8â1]).Discussion: Although overall a positive trend in QoL was observed, the formal analyses did not show any significant improvements in EQ-5D scores or VAS. Only when the effect of a therapy use was separated from the effect of switching, the VAS score was significantly worse for switchers during the follow up period, irrespective of the therapy type. If adjusted for patient characteristics and medical history (e.g., gender, BMI, eGRF, history of diabetes), VAS and EQ-5D delivered sound PRO measures for QoL assessments during the year following renal transplantation
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