Le dépôt de l’âge du Bronze moyen de Keravel en Lannilis (Finistère)

Le dépôt du Bronze moyen de Keravel en Lannilis (Finistère) fut mis au jour lors d’une opération de diagnostic archéologique en 2007. Une dizaine d’objets ou fragments d’objets fut découverte, probable reflet d’un dépôt partiellement détruit par une petite carrière d’arène granitique, creusée à une époque indéterminée. Une pointe de lance décorée et des fragments de haches à talon ou à rebord se rattachent au groupe typologique de Tréboul. Ils sont accompagnés de fragments d’une grande hache de type breton. L’ensemble, datable du xve siècle avant J.-C., s’insère dans un état des connaissances, déjà richement documenté en Bretagne, à propos de ce type de dépôts.The Middle Bronze Age Keravel hoard, Lannilis (Finistère), was discovered during an archaeological evaluation in 2007. The small assemblage of objects or fragments uncovered is probably reminiscent of a larger hoard partially destroyed by a small disused granite gravel quarry of uncertain date. A decorated spear head and some palstave or flanged-axe fragments are attributed to the Treboul Group. Fragments of a large Breton Type palstave were also present. The assemblage dates from 15th century BC and adds new material to this already well documented hoard type in Brittany

Un établissement agricole et artisanal de la fin du haut Moyen Âge au 22 de la rue Bourg-les-Bourgs à Quimper (Finistère)

Une opération de fouille préventive réalisée rue Bourg-les-Bourgs à Quimper, dans un contexte antique bien connu, met au jour les structures inédites d’un petit établissement rural daté de la fin du haut Moyen Âge, entre le ixe et le milieu du xie siècle. Celui-ci, appréhendé partiellement par l’emprise des fouilles, se caractérise par la présence de fossés d’enclos, de structures de stockage et de combustion, ainsi que de fosses aux fonctions diverses. Parmi ces vestiges, se distingue un secteur artisanal stratifié dédié à la métallurgie (activités de réduction de fer). L’analyse des structures, alliée à l’étude céramique, permet de définir l’évolution chronologique et spatiale de l’établissement. Ce dernier peut être mis en relation avec des sites contemporains situés autour du bassin de l’Odet et s’intégrer à l’Histoire quimpéroise.Excavations in advance of development at rue Bourg-les-Bourgs, Quimper, in the heart of the Roman settlement, revealed for the first time the remains of a small rural site dating, from the early medieval period, between the 9th and the middle of the 11th century. The settlement, only partially excavated, is defined by enclosure ditches, storage pits and also pits of varied usage. Other features were identified as corn-drying kiln, earth or oven and furnace. Among these features, an area for iron smelting was identified. Combined analysis of the features and the pottery assemblage allow the spatial and chronological evolution of the settlement to be defined. The settlement can be compared to contemporaneous sites located in the Odet basin and will take its place in the history of Quimper. (Trad. J.-Y. Robic

Pseudovasculitis and corticosteroid therapy

Pseudovasculitis, vasculitis-like syndromes, vasculitis look-alikes, or mimics of vasculitis represent a heterogeneous collection of disorders that are capable of simulating vasculitis. Inappropriate diagnosis leads to delay or absence of proper management and exposure to potentially deleterious treatment modalities such as corticosteroids and cytotoxic agents. We report the case of fibromuscular dysplasia suspected to be a polyarteritis nodosa. The progression of the lesions visualized by the ultrasonographic study and computed tomography (CT) scan after 10days of treatment led to an emergency laparotomy. The possible deleterious role of steroids given to treat the suspected vasculitis is discusse

Quimper – 7 rue Anatole-France, Parc-ar-Groas

Un projet immobilier, inclus dans le jardin situé 7 rue Anatole-France, a entraîné la réalisation d’une fouille d’évaluation sur une superficie d’environ 100 m2 au cœur de l’enceinte du sanctuaire de Parc-ar-Groas, sur le sommet du Mont-Frugy. L’érosion anthropique, provoquée successivement par des travaux agricoles, des entraînements militaires puis des activités de jardinage, avait détruit les sols du sanctuaire antique avant l’intervention des archéologues. Peut-être certains des travaux d..

Quimper – Place Laennec

Le réaménagement complet des places Saint-Corentin et Laennec, au cœur de la cité épiscopale de Quimper, a entraîné la réalisation d’une importante fouille de sauvetage au cours du premier semestre de l’année 1998. L’opération de diagnostic conduite en 1996 avait décelé, à faible profondeur, des vestiges de sols empierrés, d’esplanades recouvrant des cimetières médiévaux en excellent état de conservation. Un projet cohérent de fouille archéologique fut monté afin d’étudier minutieusement les ..

Method to calibrate fission chambers in Campbelling mode

Fission chambers are neutron detectors which are widely used to instrument experimental reactors such as material testing reactors or zero power reactors. In the presence of a high level mixed gamma and neutron flux, fission chambers can be operated in Campbelling mode (also known as 'fluctuation mode' or 'mean square voltage mode') to provide reliable and precise neutron related measurements. Fission chamber calibration in Campbelling mode (in terms of neutron flux) is usually done empirically using a calibrated reference detector. A major drawback of this method is that calibration measurements have to be performed in a neutron environment very similar to the one in which the calibrated detector will be used afterwards. What we propose here is a different approach based on characterizing the fission chamber response in terms of fission rate. This way, the detector calibration coefficient is independent from the neutron spectrum and can be determined prior to the experiment. The fissile deposit response to the neutron spectrum can then be assessed independently by other means (experimental or numerical). In this paper, the response of CEA made miniature fission chambers in Campbelling mode is studied. We use a theoretical model of the signal to calculate the calibration coefficient. Input parameters of the model come from statistical distribution of individual pulses. Supporting measurements have been made in the CEA Cadarache zero power reactor MINERVE. Results are compared to an empirical Campbelling mode calibration

Réhabilitation de la capacité d’évacuation des crues – intégration de "PK-Weirs" sur des barrages existants

La réhabilitation des barrages existants impose généralement une augmentation de leur capacité d’évacuation en crue. Dans de nombreuses situations, le PK-Weir (Piano Key Weir) offre à cet égard une solution compacte et efficace. La conception et la réalisation de tels ouvrages représentent un défi pour l’ingénieur, en raison de la multiplicité des conditions locales rencontrées. Cette problématique est illustrée par la présentation de deux cas réels où les questions relatives à la débitance et à la dissipation d’énergie sont examinées. Les exemples des barrages de Saint-Marc et de Gloriettes illustrent également l’importance des ouvrages de dissipation d’énergie à l’aval du PK-Weir, dont le poids, en termes de coût ou de contrainte de projet, devient prépondérant. The rehabilitation of existing dams often requires an increase of the hydraulic capacity of the spillway. In this context, the PK-Weir (Piano Key Weir) offers a compact and efficient solution. Due to the high variety of local conditions, the design and the construction of such structures is a challenge for engineers. This problematic is illustrated by two case studies, where the flood evacuation capacity of the spillway and the energy dissipation structures have been analyzed. Regarding construction constraints and costs, the examples of St-Marc’s and Gloriettes dams reveal the importance of the energy dissipation structures, which become dominant compared to the cost of the PK-Weir itself

Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)

Introduction: Patient-Reported Outcomes (PRO) integrate a wide range of holistic dimensions that arenot captured within clinical outcomes. Particularly, from induction treatment to maintenance therapy, patient quality-of-life (QoL) of kidney transplant recipients have been sparsely investigated in international settings.Methods: In a prospective, multi-centric cohort study, including nine transplant centers in four countries, we explored the QoL during the year following transplantation using validated elicitation instruments (EQ-5D-3L index with VAS) in a population of kidney transplant patients receiving immunosuppressive therapies. Calcineurin inhibitors (tacrolimus and ciclosporin), IMPD inhibitor (mycophenolate mofetil), and mTOR inhibitors (everolimus and sirolimus) were the standard-of-care (SOC) medications, together with tapering glucocorticoid therapy. We used EQ-5D and VAS data as QoL measures alongside descriptive statistics at inclusion, per country and hospital center. We computed the proportions of patients with different immunosuppressive therapy patterns, and using bivariate and multivariate analyses, assessed the variations of EQ-5D and VAS between baseline (i.e., inclusion Month 0) and follow up visits (Month 12).Results: Among 542 kidney transplant patients included and followed from November 2018 to June 2021, 491 filled at least one QoL questionnaire at least at baseline (Month 0). The majority of patients in all countries received tacrolimus and mycophenolate mofetil, ranging from 90.0% in Switzerland and Spain to 95.8% in Germany. At M12, a significant proportion of patients switched immunosuppressive drugs, with proportion varying from 20% in Germany to 40% in Spain and Switzerland. At visit M12, patients who kept SOC therapy had higher EQ-5D (by 8 percentage points, p < 0.05) and VAS (by 4 percentage points, p < 0.1) scores than switchers. VAS scores were generally lower than EQ-5D (mean 0.68 [0.5–0.8] vs. 0.85 [0.8–1]).Discussion: Although overall a positive trend in QoL was observed, the formal analyses did not show any significant improvements in EQ-5D scores or VAS. Only when the effect of a therapy use was separated from the effect of switching, the VAS score was significantly worse for switchers during the follow up period, irrespective of the therapy type. If adjusted for patient characteristics and medical history (e.g., gender, BMI, eGRF, history of diabetes), VAS and EQ-5D delivered sound PRO measures for QoL assessments during the year following renal transplantation