1,3 Dioxolane versus tetrahydrofuran as promoters for CO 2 -hydrate formation: Thermodynamics properties, and kinetics in presence of sodium dodecyl sulfate

This paper makes a comparison between tetrahydrofuran (THF) and 1,3 dioxolane (DIOX) in terms of their respective performances as promoters for the formation of clathrate hydrates with CO2. The aim is to find products that can be substituted for THF, which is known to be harmful and difficult to handle. Drawing on a review of the chemical and physical properties of these two organic compounds, experiments were performed using high-pressure differential scanning calorimetry (DSC) and a batch reactor. Details of the thermodynamic equilibria of mixed THF+CO2 and DIOX+CO2 hydrates obtained with various additive concentrations are provided, along with hydrate kinetics data relating to the hydrate formation. The effect of the presence of an anionic surfactant, SDS (sodium dodecyl sulfate), on hydrate formation kinetics was also evaluated, showing that a combination of THF or DIOX and SDS is a very advantageous solution for accelerating hydrate formation. THF has been found to outperform DIOX as a hydrate promoter from both a thermodynamic, and a kinetic standpoint in presence of SDS. However, DIOX remains an interesting practical solution, due to the benefits offered as the least toxic and aggressive of these two organic compounds

Retransfusion du sang médiastinal et thoracique épanché en période postopératoire de chirurgie cardiaque

Le saignement en chirurgie cardiaque est une préoccupation quotidienne des équipes médico-chirurgicales. L'épargne transfusionnelle est un enjeu de sécurité, de qualité et financier. La récupération sanguine postopératoire (RSPO) du sang épanché et sa retransfusion après lavage est l'un des moyens non médicamenteux préconisés pour diminuer l'incidence de la transfusion. Ce travail a pour but d'évaluer cette thérapeutique en terme de faisabilité, de coût, de retentissement et d'efficacité. Pour un saignement postopératoire médian de 900ml sur 4 heures, l'utilisation de la RSPO chez 26 patients a permis la retransfusion d'un volume de 326 ml de sang à un taux d'hématocrite de 45%, soit l'équivalent d'un concentré globulaire. Cette technique pourrait donc être intégrée à une stratégie multimodale d'épargne transfusionnelle.NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF

Ageing tests at constant currents and modelling of a High-Temperature PEMFC

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Liens entre spécificités sensorielles et sévérité des symptômes dans le trouble du spectre de l’autisme chez de jeunes enfants

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Ageing tests at constant currents and modelling of a High-Temperature PEMFC

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Multipurpose high-throughput filtering microarrays (HiFi) for DNA and protein assays

International audienceWe are reporting here a low cost colorimetric device for high-throughput multiplexed blood group genotyping and allergy diagnosis, displayed as an automated 96-well microtiter plate format. A porous polymeric membrane sealed at the bottom of each well accounts for the sensor support. For each sensing unit, a 6 x 6 matrix of specific probes is spotted on the external surface of the membrane resulting in 5 mm(2) microarrays. Thanks to the membrane porosity, reagents dispensed into the well can be eliminated through vacuum soaking. This unusual design drastically reduces the assay background signal. The system was first validated on robust models composed of either two complementary oligonucleotide sequences or one allergen/specific rabbit IgG pair. The quality of both oligonucleotide and protein immobilisation on the membrane substrate was then demonstrated together with the capacity to use the arrayed biomolecules as probes for the quantitative detection of specific targets (respectively complementary oligonucleotide and specific antibody). On the basis of these good results, two multiplex assays were developed for crude biological samples testing, focussing on two human in vitro diagnosis applications: a hybridisation assay for multiplex blood group genotyping and a multiparametric immunoassay for allergy diagnosis. In both cases, the transfer to crude biological samples testing was successful i.e. high signal to noise ratio of the stained membranes, reproducibility and good correlation with results obtained using routine testing procedures. (C) 2010 Elsevier B.V. All rights reserved

Multiplexed immunoassay for the rapid detection of anti-tumor-associated antigens antibodies

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Short report: Monitoring ESR 1 mutations by circulating tumor DNA in aromatase inhibitor resistant metastatic breast cancer

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