28 research outputs found
CONSTITUENTS OFERYTHRINA SIGMOIDEA
. The study of the secondary metabolites of the chloroform extract of the stem wood of Erythrina sigmoidea afforded a new compound a -sophoradiol (1), and the known compounds: acetate of b -amyrin (2), acetate of oleanolic acid (3), n-isocosanyl-isocosanoate (4), and n-hexatetracontanol (5). Their structures were characterised by spectroscopic methods.
(Received February 12, 2001, revised July 3, 2001)
Bull.Chem.Soc.Ethiop. 2001, 15(2), 151-15
The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
SCORODOPHLONE A, A NOVEL ALKYLSULFONE FROM THE SEEDS OF SCORODOPHLOEUS ZENKERI. HARMS
A novel alkylsulfone, scorodophlone A 1, from the seeds of Scorodophloeus zenkeri Harms, has been assigned the structure 6-(methylsulfonyl)-1,2,3-dithiazinan-4-one on the basis of its spectroscopic properties. The known compounds α-sophoradiol (12-oleanene-3β,22α-diol), lupeol and sitosterol were also obtained.
KEY WORDS: Scorodophloeus zenkeri, Caesalpiniaceae, Scorodophlone A, Pentacyclic triterpene, Phytosterol
Bull. Chem. Soc. Ethiop. 2006, 20(1), 173-176
Constituents of <i>erythrina sigmoidea</i>
The study of the secondary metabolites of the chloroform extract of the stem wood of Erythrina sigmoidea afforded a new compound a-sophoradiol (1), and the known compounds: acetate of b-amyrin (2), acetate of oleanolic acid (3), n-isocosanyl-isocosanoate (4), and n-hexatetracontanol (5). Their structures were characterised by spectroscopic methods
Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco)
Fomani M, Ngeufa Happi E, Nouga Bisoue A, et al. Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco). Bioorganic & Medicinal Chemistry Letters. 2015;26(2):306-309
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The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids Amoa Onguéné et al
ntral</Provider><DateDelivered>2013-12-28T14:13:49</DateDelivered><Date plants, part I: a pharmacological evaluation of alkaloids and terpenoids
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New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)
Fractionation of a MeOH/CH2Cl2 (1/1) extract of the aerial parts of Senecio erechtitoides led to the isolation of six compounds including the hitherto unknown N-phenethylamide derivative named N-(p-hydroxyphenethyl)pentacosanamide (1), and a kauranoid derivative named derivative named ent-7-oxo-16 alpha,17-dihydroxykauran-19-oic acid (2), as well as four known compounds, ent-Kaur-16-en-19-oic acid (3), ent-7 beta-hydroxykaur-16-en-19-oic acid (4), ent-7-oxokaur-16-en-19-oic acid (5), steppogenin 4′-O-beta-d-glucoside (6). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, chemical reactions, and comparison with previously known analogs. All isolates were evaluated for their antimicrobial activity and only diterpenoids were found to possess a potent inhibitor effect against the range of microorganism
Two new 30-norfriedelane triterpenes from Caloncoba glauca (P. Beauv.) Gilg (Achariaceae)
Ndoumbe Tamba C, Tsopgni WDT, Fotso BSH, et al. Two new 30-norfriedelane triterpenes from Caloncoba glauca (P. Beauv.) Gilg (Achariaceae). Natural Product Research . 2023.The chemical investigation of the methanolic root extract of Caloncoba glauca (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B (1-2), together with eight known compounds, caloncobalactone (3), friedelin (4), friedelanol (5), 3-oxo-friedelan-28-oic acid (6), stigmasterol (7), beta-sitosterol (8), beta-sitosterol-3-O-beta-D-glucopyranoside (9) and pentacosanoic acid (10). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 125mug/mL against Staphylococcus aureus and Escherishia coli. Compound 6 exhibited moderated antifungal activity against Candida krusei with MIC value of 62.5mug/mL. All the isolates were found to be inactive as antioxidants in the DPPH, ABTS and FRAP assays
Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae)
Tameye SCP, Mbeunkeu ABD, Fouokeng Y, et al. Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters. 2021;43:150-153.Phytochemical investigation of the stem barks of Ficus exasperata Vahl. (Moraceae) led to the isolation of two new cinnamic acid derivatives stereoisomers, named ficusanolide A (1) and ficusanolide B (2) along with twelve known compounds: ficusanol (3), umbelliferone-6-carboxylic acid (4), oxypeucedanin hydrate (5), marmesin (6), decursinol (7), beta-amyrin acetate (8), lupeol (9), betulinic acid (10), ursolic acid (11), a mixture of stigmasterol (12) and beta-sitosterol (13), sitosteryl-3-O-beta-D-glucopyranoside (14); and one hemisynthetic derivative : per acetylated betulinic acid (15). Their structures were established by the means of their physical data (melting point, rotatory power), their spectroscopic data, particularly IR, NMR (1H, 13C, DEPT, COSY, HSQC and HMBC) data, and HR-ESIMS data. Crude extract, compounds 1, 2, 3, 5, 6, 7, 9, 10, 11, as well as the semisynthetic derivative 15 were evaluated for their cytotoxic activity on the human cervix carcinoma cell line KB-3-1 and the human colon cancer cell line HT-29. Ursolic acid 11 showed a moderate activity on both cancer cells tested with IC50s of 50.9 mu M and 34.4 mu M respectively