Hallazgos de la tomografía computarizada de cráneo en pacientes pediátricos con cefalea, tendidos en el hospital Manuel de Jesús Rivera "La Mascota" de enero a junio del 2016

La cefalea es un síntoma muy frecuente en la edad pediátrica, y a veces de mucho tiempo de evolución, por lo cual es necesario realizar un estudio neurológico acompañado con estudios de imagen para obtener un diagnóstico. Actualmente la tomografía de cráneo es un examen muy utilizado e indicado en niños, llevando en muchas ocasiones a un uso innecesario que aumenta riesgos para el paciente y costos para la unidad. Determinar los principales hallazgos de la tomografía de cráneo en pacientes pediátricos que acuden con cefalea atendidos en el hospital Manuel de Jesús Rivera “La Mascota” de enero a junio del 2016 Se realizó un estudio descriptivo de corte transversal, en 90 pacientes pediátricos que acudieron al hospital aquejando cefalea de larga evolución, se diseñó una base de datos en SPSS22, realizando un análisis univariado, estimando frecuencias y porcentajes, así como medidas de tendencia central. Se muestran los resultados en tablas y gráficos. La edad promedio de los pacientes fue de 9 años, el grupo etáreo predominante fue de 12 años, con un 43,4%, siendo 50% mujeres y 50% varones. 31,1% de tomografías de cráneo fueron clasificadas como anormales.El hallazgo tomografíico más frecuente fue sinusitis. En el 100% de pacientes la cefalea se clasificó como primaria. El tiempo de evolución de la cefalea fue menor de 1 mes para un 37,8%. Como diagnostico presuntivo predominante fue el tumor cerebral con un 72,2%. Sólo un 33,3% de tomografías estuvieron adecuadamente indicadas. Más de la mitad de tomografías de cráneo realizadas en los pacientes pediátricos resultaron normales, sin aportar hallazgos relevantes para el diagnóstico de la cefalea

Additional file 1: of Memory is preserved in older adults taking AT1 receptor blockers

Baseline medications. (DOC 29 kb

Right atrial volume by cardiovascular magnetic resonance predicts mortality in patients with heart failure with reduced ejection fraction

<div><p>Background</p><p>Right Atrial Volume Index (RAVI) measured by echocardiography is an independent predictor of morbidity in patients with heart failure (HF) with reduced ejection fraction (HFrEF). The aim of this study is to evaluate the predictive value of RAVI assessed by cardiac magnetic resonance (CMR) for all-cause mortality in patients with HFrEF and to assess its additive contribution to the validated Meta-Analysis Global Group in Chronic heart failure (MAGGIC) score.</p><p>Methods and results</p><p>We identified 243 patients (mean age 60 ± 15; 33% women) with left ventricular ejection fraction (LVEF) ≤ 35% measured by CMR. Right atrial volume was calculated based on area in two- and four -chamber views using validated equation, followed by indexing to body surface area. MAGGIC score was calculated using online calculator. During mean period of 2.4 years 33 patients (14%) died. The mean RAVI was 53 ± 26 ml/m²; significantly larger in patients with than without an event (78.7±29 ml/m² vs. 48±22 ml/m², p<0.001). RAVI (per ml/m²) was an independent predictor of mortality [HR = 1.03 (1.01–1.04), p = 0.001]. RAVI has a greater discriminatory ability than LVEF, left atrial volume index and right ventricular ejection fraction (RVEF) (C-statistic 0.8±0.08 vs 0.55±0.1, 0.62±0.11, 0.68±0.11, respectively, all p<0.02). The addition of RAVI to the MAGGIC score significantly improves risk stratification (integrated discrimination improvement 13%, and category-free net reclassification improvement 73%, both p<0.001).</p><p>Conclusion</p><p>RAVI by CMR is an independent predictor of mortality in patients with HFrEF. The addition of RAVI to MAGGIC score improves mortality risk stratification.</p></div

ROC analysis.

<p>ROC analysis.</p

Mortality estimates by RAVI more or less than the median at the time of CMR imaging.

<p>Mortality estimates by RAVI more or less than the median at the time of CMR imaging.</p

Multivariable Cox Proportional Hazard Model.

<p>Multivariable Cox Proportional Hazard Model.</p

Baseline characteristics.

<p>Baseline characteristics.</p

Patient flow chart.

<p>Patient flow chart.</p

Discrimination analysis.

<p>Discrimination analysis.</p

Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals

<div><p>Context</p><p>Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results.</p><p>Objective</p><p>We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding.</p><p>Data sources and Study Selection</p><p>Original articles published in three calendar years (1988, 1998, and 2008) in The Lancet, New England Journal of Medicine and Journal of American Medical Association were collected.</p><p>Data Extraction</p><p>Studies were reviewed and investigational design categorized as prospective and retrospective clinical trials. Prospective trials were categorized into randomized or non-randomized and single-center or multi-center trials. Retrospective trials were categorized as registries, meta-analyses and other studies, mostly comprising of case reports or series. Study outcomes were categorized as positive or negative depending on whether the pre-specified hypothesis was met. Financial disclosures were researched for financial relationships and profit status, and accordingly categorized as government, non-profit or industry sponsored. Studies were assessed for reporting COI.</p><p>Results</p><p>1,671 original articles were included in this analysis. Total number of published studies decreased by 17% from 1988 to 2008. Over 20 year period, the proportion of prospective randomized trials increased from 22 to 46% (p < 0.0001); whereas the proportion of prospective non-randomized trials decreased from 59% to 27% (p < 0.001). There was an increase in the percentage of prospective randomized multi-center trials from 11% to 41% (p < 0.001). Conversely, there was a reduction in non-randomized single-center trials from 47% to 10% (p < 0.001). Proportion of government funded studies remained constant, whereas industry funded studies more than doubled (17% to 40%; p < 0.0001). The number of studies with negative results more than doubled (10% to 22%; p<0.0001). While lack of funding disclosure decreased from 35% to 7%, COI reporting increased from 2% to 84% (p < 0.0001).</p><p>Conclusion</p><p>Improved reporting of COI, clarity in financial sponsorship, increased publication of negative results in the setting of larger and better designed clinical trials represents a positive step forward in the scientific publications, despite the higher percentage of industry funded studies.</p></div