Randomised trials relevant to mental health conducted in low and middle-income countries: protocol for a survey of studies published in 1991, 1995 and 2000 and assessment of their relevance

BACKGROUND A substantial proportion of the psychiatric burden of disease falls on the world's poorest nations. Despite this, relatively little is known about the quality and content of clinical research undertaken in these countries, or the relevance of the interventions evaluated and specifically that of randomised trials. This project aims to survey the content, quality and accessibility of a sample of trials relevant to mental health conducted within low and middle-income countries; to compare these with studies conducted in high-income countries; and to assess their relevance for the needs of low and middle-income countries. METHODS An extensive search for all trials, or possible trials, published in 1991, 1995 and 2000 with participants in low and middle-income countries has already been conducted. Studies evaluating prevention or treatment of a mental health problem within these three years will be identified and further searches conducted to assess completeness of the initial search. Data on study quality and characteristics will be extracted from each report. Accessibility will be estimated based on whether each citation is available on MEDLINE. Trials relevant to schizophrenia will be compared with a random sample of schizophrenia trials from high-income countries in the same years. Topics covered by the trials will be compared with the estimated burden of disease. CONCLUSION Trials and systematic reviews of trials are the gold standard of evaluation of care and increasingly provide the basis for recommendations to clinicians, to providers of care and to policy makers. Results from this study will present the first assessment of the scope, quality and accessibility of mental health trials in low and middle-income countries

Some experience in the production of high silicon Fe-Mn at TISCO Joda Plant

The paper describes the experience gained over the last few years in the production of Silico manganese at Ferro Manganese Plant, Joda. The quality of the quartzite is a very important factor governing the level of silicon in the alloys. An alloy of 16% silicon could be produced successfully with 96% SiO2 in the quartzite. Trials in the production of the alloy and the improvement effected of its grade has also been discussed

Geometric Mechanics of Contact-Switching Systems

Discrete and periodic contact switching is a key characteristic of steady state legged locomotion. This paper introduces a framework for modeling and analyzing this contact-switching behavior through the framework of geometric mechanics on a toy robot model that can make continuous limb swings and discrete contact switches. The kinematics of this model forms a hybrid shape space and by extending the generalized Stokes' theorem to compute discrete curvature functions called stratified panels, we determine average locomotion generated by gaits spanning multiple contact modes. Using this tool, we also demonstrate the ability to optimize gaits based on system's locomotion constraints and perform gait reduction on a complex gait spanning multiple contact modes to highlight the scalability to multilegged systems.Comment: 6 pages, 7 figures, and link to associated video: https://drive.google.com/file/d/12Sgl0R1oDLDWRrqlwwAt3JR2Gc3rEB4T/view?usp=sharin

HIghMass - High HI Mass, HI-Rich Galaxies at z∼0z\sim0: Combined HI and H2_2 Observations

We present resolved HI and CO observations of three galaxies from the HIghMass sample, a sample of HI-massive ($M_{HI} > 10^{10} M_\odot$), gas-rich ($M_{HI}$ in top $5\%$ for their $M_*$) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low surface brightness galaxies, and have typical specific star formation rates (SFR$/M_*$) for their stellar masses. The three galaxies have normal star formation rates for their HI masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of HI to H$_2$, not in converting H$_2$ to stars. In addition, their dark matter spin parameters ($\lambda$) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but are now becoming active, in agreement with prior H$\alpha$ observations.Comment: 20 pages, 13 figure

Assessing airway inflammation in clinical practice – experience with spontaneous sputum analysis

<p>Abstract</p> <p>Background</p> <p>The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, however, does have its limits and therefore there will always be a need for methods enabling a direct evaluation of airway inflammatory cell composition. Sampling of spontaneous sputum is a well-known, simple, economic and non-invasive method to derive a qualitative cytology of airway cells and here we aimed to assess today's value of spontaneous sputum cytology in clinical practice.</p> <p>Methods</p> <p>Three pneumologists provided final diagnoses in 481 patients having sputum cytology and we retrospectively determined posterior versus prior probabilities of inflammatory airway disorders. Moreover, in a prospective part comprising 108 patients, pneumologists rated their confidence in a given diagnosis before and after knowing sputum cytology and rated its impact on the diagnostic process on an analogue scale.</p> <p>Results</p> <p>Among the 481 patients, 45% were diagnosed as having asthma and/or airway hyperresponsiveness. If patients showed sputum eosinophilia, the prevalence of this diagnosis was elevated to 73% (n = 109, p < 0.001). The diagnosis of COPD increased from 40 to 66% in patients with neutrophilia (n = 29, p < 0.01).</p> <p>Thirty-three of the 108 patients were excluded from the prospective part (26 insufficient samples, 7 incomplete questionnaires). In 48/75 cases the confidence into a diagnosis was raised after knowing sputum cytology, and in 15/75 cases the diagnosis was changed as cytology provided new clues.</p> <p>Conclusion</p> <p>Our data suggest that spontaneous sputum cytology is capable of assisting in the diagnosis of inflammatory airway diseases in the outpatient setting. Despite the limitations by the semiquantitative assessment and lower sputum quality, the supportive power and the low economic effort needed can justify the use of this method, particularly if the diagnosis in question is thought to have an allergic background.</p