A case of advanced infantile myofibromatosis harboring a novel MYH10‐RET fusion

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137282/1/pbc26377_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137282/2/pbc26377.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137282/3/pbc26377-sup-0002-text.pd

Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors

A pediatric study has established a maximum tolerated dose (MTD) for temsirolimus (Tem) of more than 150 mg/m2 IV/week. A phase I trial was conducted to establish the MTD for Tem in combination with valproic acid (VPA) in children and adolescents with refractory solid tumors. Secondary aims included expression of mTOR markers on archival tumor tissue; Tem pharmacokinetics (PK); assessment of histone acetylation (HA); and tumor response

Spatial and temporal patterns of herbaceous primary production in semi-arid shrublands: a remote sensing approach

Questions: Can herbaceous above-ground net primary production (ANPP) be estimated from remote sensing when woody and herbaceous plants are intermingled? How does herbaceous ANPP change in space and time in an ecosystem dominated by woody species? What are the main controls of herbaceous ANPP to paddock scale?. Location: Native plant communities and buffelgrass roller chopped pastures of the Arid Chaco, western Argentina (28–32° S, 64–67° W; area: 100 000 km2). Methods: We decomposed normalized difference vegetation index (NDVI) data from MODIS (pixel size: 250 m × 250 m) into woody (W) and herbaceous (H) components. We calibrated the relationship between field estimates of herbaceous ANPP and the H component of NDVI using linear regression. The regression model fitted was applied to a 10-yr MODIS database for four paddocks to estimate herbaceous ANPP. We analysed the relationship between herbaceous ANPP and watering point distance and growing season precipitation. Results: The annual integral of NDVI × proportion of the herbaceous component [H/(H + W)] explained 71% and 91% of herbaceous ANPP variation in native plant communities and buffelgrass roller chopped pastures, respectively. The regression model fitted, however, differed (P < 0.05) between the two types of system. The NDVI annual integral explained a higher proportion of herbaceous ANPP variations than the NDVI annual peak or the growing season (December–April) integral. For native plant communities, herbaceous production increased significantly (P < 0.05) with watering point distance, and marginally significantly (P < 0.10) with growing season precipitation. For buffelgrass roller chopped pastures, the herbaceous production increased significantly (P < 0.05) with growing season precipitation. Conclusion: Our model was able to estimate herbaceous ANPP from the decomposition of an NDVI time series that included woody components. Thus, the model provides the basis for more accurate monitoring of spatial and temporal variability of herbaceous ANPP in areas where herbaceous and woody plant components co-exist. Applying our models, we detected clear spatial and temporal patterns of herbaceous ANPP. The possibility of describing in a spatially explicit way the past 14 yrs of herbaceous ANPP allows designing livestock management strategies and devise alternatives to control degradation processes in the Arid Chaco.Fil: Blanco, Lisandro Javier. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Catamarca-La Rioja. Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Paruelo, José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de Agronomía. ; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información; ArgentinaFil: Oesterheld, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura. Universidad de Buenos Aires. Facultad de Agronomía. ; ArgentinaFil: Biurrun, Fernando N.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Catamarca-La Rioja. Estación Experimental Agropecuaria La Rioja; Argentin

Radiation use efficiency of the herbaceous layer of dry Chaco shrublands and woodlands: Spatial and temporal patterns

Aims: Monitoring rangeland above-ground net primary production (ANPP) requires information on the variation of radiation use efficiency (RUE). We studied the spatial and temporal variations of RUE of the herbaceous layer (RUEH) in woodlands and shrublands and its association with grazing regime, environmental, and vegetation variables. Location: We worked in the Arid Chaco (Argentina), an ecotone region between the Chaco and Monte phytogeographic provinces. Woody and herbaceous species coexist in variable proportions in relation to a regional precipitation gradient and local edaphic variations. Methods and results: Over eight growing seasons, we estimated RUEH at 12 sites, each with two contrasting grazing regimes (moderate and severe). To do this, we related estimated ANPPH from biomass harvests and APARH (absorbed photosynthetically active radiation of the herbaceous layer) calculated from the MODIS normalized difference vegetation index (NDVI). Then we linked the RUEH with precipitation, physiognomy, soil, and landscape data. Most of the spatial variability of RUEH was accounted for by the grazing regime. Moderately grazed areas had a three times greater RUEH than severely grazed ones (0.507 and 0.180 g MJ−1 respectively). They also exhibited different proportions of herbaceous functional types. Physiognomic characteristics of the woody layer explained a significant proportion of the spatial variation of RUEH not explained by grazing regime. RUEH was between 30 and 150% greater in woodlands than in shrublands depending on whether the sites were under moderate or severe grazing respectively. Conclusion: Grazing regime and woody physiognomy accounted for most of the variation in herbaceous radiation use efficiency. Our results show that RUEH may be predicted with greater accuracy from a combination of vegetation maps and information on grazing regime. Thus, our models could be incorporated into web platforms that provide ANPPH (forage) monitoring services based on satellite data, in order to improve their estimates in woodlands, shrublands and savanna ecosystems.EEA La RiojaFil: Blanco, Lisandro Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Paruelo, José María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Paruelo, José María. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Paruelo, José María. Instituto Nacional de Investigación Agropecuaria (INIA). El Semillero; UruguayFil: Oesterheld, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Oesterheld, Martin. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura; ArgentinaFil: Agüero, Walter Damian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; Argentin

Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors

A pediatric study has established a maximum tolerated dose (MTD) for temsirolimus (Tem) of more than 150 mg/m2 IV/week. A phase I trial was conducted to establish the MTD for Tem in combination with valproic acid (VPA) in children and adolescents with refractory solid tumors. Secondary aims included expression of mTOR markers on archival tumor tissue; Tem pharmacokinetics (PK); assessment of histone acetylation (HA); and tumor response