The effect of an iodine restricted including no sea foods diet, on technetium-99m thyroid scintigraphy: A neglected issue in nuclear medicine practice

Although it is recommended to patients to avoid sea food and iodine-containing medications prior to iodine-131 ( 131I) scanning, the efficacy of this diet as for technetium-99m pertechnetate ( 99mTc-P) thyroid scintigraphy is not well addressed in the literature. We evaluated a self-managed, outpatients, iodine restricted diet (IRD) designed to reduce total body iodine in preparation for such a scan. We have studied 39 patients who referred to our Department for multinodular goiter, 30 females and 9 males, aged: 14-54 years and their 99mTc-P thyroid scintigraphy showed poor visualization of the thyroid gland. These patiens were living in regions with high consumption of sea foods went underwent a two-weeks iodine restriction including restriction of sea food diet for the reduction of iodine body content. These patients were called for a repeated scan after going on a IRD for at least two weeks. The two scans were compared visually, and by semiquantitative analysis. Semiquantitative analysis was applied in 8 regions of interest (ROI) by using Wilcoxon signed rank test. Thirty-six subjects had better quality scintigraphy images in the post IRD thyroid scan, as was visually assessed by two nuclear medicine physicians. Semiquantitatetively, there was a significant difference in the mean counts of ROI of the right and the left thyroid lobes in favor of the post IRD scans (P<0.05). In conclusion, this study suggests that in patients with multinodular goiter, living in regions with high consumption of sea foods a two-weeks diet for the reduction of iodine body content induces in most of the cases a slightly better diagnostic thyroid 99mTc-P scan

99mTc-MIBI Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study

The differentiation of active inflammatory processes from an inactive form of the disease is of great value in the management of interstitial lung disease (ILD). The aim of this investigation was to assess the efficacy of 99mTc-methoxy-isobutyl-isonitrile (99mTc-MIBI) scans in distinguishing the severity of the disease compared to radiological and clinical parameters.In total, 19 known cases of ILD were included in this study and were followed up for 1 year. Five patients without lung disease were considered as the control group. The patients underwent pulmonary function tests (PFTs) and high-resolution computed tomography scans, followed by 99mTc-MIBI scanning. The 99mTc-MIBI scans were analyzed either qualitatively (subjectively) or semiquantitatively.All 19 ILD patients demonstrated a strong increase in 99mTc-MIBI uptake in the lungs compared to the control group. The 99mTc-MIBI scan scores were higher in the patient group in both the early phase (0.240.19-0.31 vs 0.110.10-0.15, P 0.14). The 99mTc-MIBI scan scores were not significantly correlated with the PFT findings (P > 0.05). In total, 5 patients died and 14 patients were still alive over the 1-year follow-up period. There was also a significant difference between the uptake intensity of 99mTc-MIBI and the outcome in the early phase (dead: 0.320.29-0.43 vs alive: 0.210.18-0.24, P < 0.05) and delayed phase (dead: 0.270.22-0.28 vs alive: 0.100.07-0.19, P < 0.05).The washout rate was ~40 min starting from 20 min up to 60 min and this rate was significantly different in our 2 study groups (ILD: 46.6115.61-50.39 vs NL: 70.9127.09-116.36, P = 0.04).The present study demonstrated that 99mTc-MIBI lung scans might distinguish the severity of pulmonary involvement in early views, which were well correlated with HRCT findings. These results also revealed that 99mTc-MIBI lung scans might be used as a complement to other diagnostic and clinical examinations in terms of functional information in ILD; however, further investigations are strongly required

The role of 99mTc-Ubiquicidin (UBI) and 99mTc-IgG scintigraphies in diagnosis of acute appendicitis: A preliminary result

Introduction: Appendicitis is one of the most common surgical emergencies. In spite of the relatively high rate of negative appendectomy, as a result of miss diagnosis, uncertainty of diagnosis still continues to challenge physicians. The objective of this prospective study was to investigate the role of 99mTc-Ubiquicidin (UBI) scintigraphy in the diagnosis of acute appendicitis and to compare 99mTc-UBI scintigraphy with 99mTc-IgG scintigraphy. Methods: Twelve patients with right lower quadrant pain and suspicious of acute appendicitis were referred to the nuclear medicine imaging center. Radionuclide imaging was performed with 99mTc-UBI in 8 and 99mTc-IgG in 4 patients. Ultrasonography, Alvarado scoring and histopathological examinations were also performed as additional diagnostic tests. Results: Reports from 99mTc-IgG and 99mTc-UBI scintigraphies of all patients were negative. Conclusion: This study may conclude that 99mTc-IgG scintigraphy and 99mTc-UBI scintigraphy in the detection of appendicitis do not have adequate efficacy. However, in order to better evaluate 99mTc-IgG and 99mTc-UBI scintigraphy, a comprehensive study on a large number of patients with clinical suspicious of acute appendicitis would be more helpful

Effect of Mono Ethylene Glycol Solution on Mechanical Behavior of a Clay Soil

This is the author accepted manuscript. The final version is available from ASTM International via the DOI in this record This article presents the results of an investigation into the behavior of a clay soil contaminated with mono ethylene glycol (MEG) through a program of experimental tests. Soil specimens were prepared with water or different concentrations (10, 25 and 40 %) of MEG by the slurry method. One-dimensional consolidation and consolidated undrained (CU) triaxial tests were performed on the specimens. The results of the consolidation tests showed that the preconsolidation pressure is increased and the value of λ (slope of normal consolidation line) is decreased with an increase in the concentration of MEG. In addition, the results of the CU triaxial tests indicated that the friction angles (in term of total and effective stresses) are greater for the MEG solution than for water as pore fluid, and their values are increased with an increase in the concentration of the MEG solution. It was also shown that Roscoe surface exists for contaminated soil in q, p′, v space, and its position in this space is dependent on the concentration of pore fluid

Relation between clinical features and gastric emptying time in diabetic patients

BACKGROUND: Gastroparesis is characterized by delayed gastric emptying. This pathology is usually observed in patients with diabetes. One standard approach to quantitative assessment of gastric emptying is scintigraphic study. The aim of present study was to perform scintigraphic study of gastric emptying time in patient with diabetes and to find its correlation with patients' characteristics. MATERIALS AND METHODS: Gastric emptying was assessed in 19 patients with type 2 diabetes (mean age of 61.04 ± 6.09 years) and 6 healthy volunteers. Characteristics of the patients were sex, age, duration of diabetes, blood sugar and serum HbA1c level. RESULTS: Results of present study revealed that gastric emptying half time was significantly larger in patients with type 2 diabetes as compared with healthy volunteers (P-value < 0.05). While correlation of sex, age, duration of diabetes and blood sugar with gastric emptying time was not statistically significant, HbA1c level had significant effect on gastric emptying time. CONCLUSION: Results of this prospective study indicated that level of serum HbA1c is an effecting factor on gastric emptying time in patients with type 2 diabetes; however, these preliminary findings should be validated in larger and well-designed studies. Copyright © 2015 Via Medica

The association of increased stomach wall radiotracer uptake with prolonged use of Omeprazole capsules on myocardial perfusion imaging (MPI) using 99mTc-sestamibi SPECT

Myocardial perfusion imaging (MPI) is widely used in routine practice for diagnosis and risk stratification of coronary artery disease (CAD). Intense curvilinear activity in the stomach wall of a patient was seen on MPI raw data. This phenomenon was completely dissimilar to the familiar intraluminal gastric reflux of sestamibi. This observed activity could have resulted in false-positive or false-negative artifacts - and inaccurate diagnosis - of the inferior wall of the left ventricle after MPI processing. On further exploration, the current researchers found that the patient had a history of 10-year Omeprazole capsule consumption. The authors present this infrequent case of intense stomach uptake to stress the related clinical and diagnostic implications with the aim to stimulate acute awareness of possible, unexpected infringements on image quality that could potentially interfere with accurate interpretation of the data. Copyright © 2013 Via Medica

Strength of a clay soil and soil-cement mixture with resin

This is the final version of the article. Available from European Geosciences Union via the DOI in this record.A series of laboratory experiments were carried out to investigate the effect of resin on the strength of a clay soil and soil-cement mixtures. One group of tests were carried out on samples of the clay soil that were prepared with different resin contents. Another group of tests were conducted on mixtures of soil-cement and soil-cement-resin with specified resin contents. The results show that adding more than 10% resin increases the strength of the soil, whereas at resin contents below 10% no significant effect was observed. The strengths of the samples of soil, soil- cement mixture and soil-cement-resin mixture increased with increasing percentages of cement and resin. The results also show that the increase in strength is a function of percentage of agents and curing time

Concurrent papillary thyroid cancer and parathyroid adenoma as a rare condition: A case report

Although the pathological relationship between parathyroid and thyroid diseases is common, an association between parathyroid adenoma and thyroid cancer is rare. Concomitant thyroid cancer in patients with primary hyperparathyroidism (pHPT) has been reported at varying frequencies. WE present here a 23-year-old man who had papillary thyroid carcinoma in the right thyroid lobe and a parathyroid adenoma in the left thyroid lobe, which were confirmed surgically. Copyright © 2012 Via Medica

Efficient out-coupling of high-purity single photons from a coherent quantum dot in a photonic-crystal cavity

We demonstrate a single-photon collection efficiency of $(44.3\pm2.1)\%$ from a quantum dot in a low-Q mode of a photonic-crystal cavity with a single-photon purity of $g^{(2)}(0)=(4\pm5)\%$ recorded above the saturation power. The high efficiency is directly confirmed by detecting up to $962\pm46$ kilocounts per second on a single-photon detector on another quantum dot coupled to the cavity mode. The high collection efficiency is found to be broadband, as is explained by detailed numerical simulations. Cavity-enhanced efficient excitation of quantum dots is obtained through phonon-mediated excitation and under these conditions, single-photon indistinguishability measurements reveal long coherence times reaching $0.77\pm0.19$ ns in a weak-excitation regime. Our work demonstrates that photonic crystals provide a very promising platform for highly integrated generation of coherent single photons including the efficient out-coupling of the photons from the photonic chip.Comment: 13 pages, 8 figures, submitte

The role of gated myocardial perfusion scintigraphy (GMPS) in myocarditis: A case report and review of the literature

Acute myocarditis is one of the most challenging diagnoses and treatments in cardiology. The acute viral myocarditis diagnosis is usually based on high suspicion, history taking, and physical examination. Likewise, the use of chest radiography, electrocardiography (ECG), and echocardiography is helpful in making a final diagnosis, but all are non-specific. In addition, in imaging query, magnetic resonance imaging (MRI) depicts some degree of cardiac inflammation in the course of myocarditis. Myocardial perfusion imaging (MPI) has also been shown to be useful in diagnosis, and this noninvasive technique diminishes the need for myocardial biopsy. The current study presents the diagnostic and prognostic role of MPI in a 25-year-old patient with suspected myocarditis. The patient underwent gated-technetium-99m-lablled, methoxyisobutyl isonitrile, single photon emission computed tomography (Gated 99mTc-MIBI SPECT) that showed nonheterogeneous absorption with remarkable decreased radiotracer uptake in the myocardium in both stress and rest phases. In addition, the gated mode demonstrated decreased wall motion and thickening of the myocardium with a sum motion score (SMS) of 28, a sum thickening score (STS) of 15, and a measured LVEF of 34%. The study concludes that 99mTC-MIBI SPECT imaging is a useful modality in the preparation of supplementary diagnostic and prognostic information in viral myocarditis. Copyright © 2011 Via Medica