„Zielone kompetencje” młodzieży

Artykuł zamieszczony jest w : Życie Uczelni : biuletyn informacyjny Politechniki Łódzkiej, nr 155, Luty 2021W obliczu zmian klimatycznych i dynamicznie zmieniającej się gospodarki poszukiwane są rozwiązania, które wspierają dążenie do bardziej zrównoważonego, „zielonego” świata. Na te potrzeby odpowiada europejski projekt Design4Climate, którego koordynatorem jest Politechnika Łódzka. Jest on finansowany z programu Erasmus+ i wiąże się z rozwijaniem „zielonych kompetencji” młodzieży kształcącej się w szkolnictwie technicznym i zawodowym

Multisystem presentation of Late Onset Pompe Disease: what every consulting neurologist should know

Introduction. Pompe disease is a rare, autosomal recessive, lysosomal disorder caused by deficiency of alpha glucosidase (GAA). It leads to the accumulation of glycogen in body tissues, with severe myopathy and cardiomegaly as a hallmark of the classic infantile form. Non-classical, or late onset, Pompe disease (LOPD) manifests after 12 months of age or in adulthood. Material and methods. The clinical heterogeneity of LOPD causes delay in diagnosis and pharmacological treatment. In the Polish population, it is still underdiagnosed, and the time from onset to diagnosis remains a cause for concern. Clinical implications. Although typically patients present with proximal muscle weakness, high CK or early respiratory insufficiency, they can also suffer from multiple symptoms from other organs. Patients may present with arrhythmias, vascular abnormalities including aneurysms or dilative arteriopathy, gastric or urinary symptoms, or musculoskeletal pathologies. Results. A high index of suspicion among neurologists consulting internal medicine wards would aid early diagnosis of LOPD, while a multidisciplinary approach with the involvement of other specialists can reduce the risk of complications and improve the prognosis for LOPD patients. Patients who manifest with musculoskeletal and respiratory symptoms are prone to be diagnosed sooner than individuals with non-muscular symptoms, and therefore it is important to raise awareness of other manifestations of this disease

Conflict Behavior in Show Jumping Horses: A Field Study

peer-reviewedThe study objective was to determine if there was a relationship between behavioral and physiological stress measures in sport horses and their performance. Nineteen horses competed in show jumping events (6 housed at the center and 13 transported), while 5 horses at home training served as controls. The competition horses were assigned to “light” (obstacles ≤100 cm) and “difficult” class (obstacles >100 cm). The conflict behaviors (CBs/min) in two rounds were calculated. Total faults were classified as “less faults” (≤one fault) or “more faults” (>one fault). Salivary cortisol concentration (SCC) before the first round (SCC-SP1), 20 minutes (SCC-SP2), and 60 minutes after the second round (SCC-SP3) was measured. The increase (SCC-in) and decrease (SCC-dec) in SCC were calculated. No effect of competition was found. Horses that waited longer for the second round had greater CB (P < .05). Conflict behavior was more frequent in horses from the “more faults” (P = .05) and “difficult” (a tendency; P = .06) classes. No correlation of CB with SCC was found. SCC-SP2 was greater in “more faults” (P < .01) and “transported” (P < .01) horses. Competition increased the SCC (P < .05), whereas SCC-SP2 was greater in less successful horses (P < .05). Transported horses and horses with more faults had the greatest SCC-SP2 and SCC-dec (P < .05). Our results suggest that horses which presented stress response were also less successful in competition. The adoption of effective methods to reduce transport and competition stress could enhance welfare and performance of sport horses during competition

The effect of multiple nutritional factors on hypothyroidism - a systemic review

Objective: The study aims to investigate the impact of various supplements, namely selenium, vitamin D, zinc, magnesium, vitamin A, iodine, L-carnitine, and proteolytic enzymes, on the management of hypothyroidism, with a particular focus on Hashimoto’s thyroiditis. Materials and Methods: The PubMed database was searched using the keywords „Hashimoto,” „hypothyroidism,” „sport,” „physical activity,” and „diet.” Results: Several studies show that supplements can help manage hypothyroidism. Vitamin D lowers TSH levels, with varying effects on thyroid hormones. Selenium reduces TPOAb, TGAb, and TSH levels, and boosts antioxidant activity, indicating potential immune benefits. Zinc is crucial for thyroid hormone synthesis, with supplementation improving fT3 levels. Magnesium and vitamin A together enhance thyroid function and reduce inflammation. Adequate iodine intake supports thyroid function, while both deficiency and excess can cause thyroid issues. L-carnitine reduces fatigue by enhancing energy metabolism, and proteolytic enzymes have anti-inflammatory effects, aiding autoimmune thyroid disease management. Conclusions: The study highlights the potential benefits of supplementing mentioned nutrients in managing hypothyroidism by improving thyroid function, reducing inflammation, and better overall health in hypothyroid patients. Further large-scale, long-term studies are required to confirm these findings and determine optimal dosages and combinations for better effectiveness

Comprehensive Insights into Neuropsychiatric Systemic Lupus Erythematosus

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, often affecting women of childbearing age, with periods of exacerbations and remissions. SLE can impact multiple organs, causing a range of clinical symptoms. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes symptoms like headaches, seizures, anxiety disorders, cognitive dysfunctions, psychosis, and neuropathies. Its diagnosis is challenging, and treatment is complex. Purpose: This study aims to explain the pathophysiology of NPSLE, describe diagnostic methods, and summarize current treatment methods based on recent research. Methods: Databases such as PubMed, Medline, and ResearchGate were used. State of current knowledge: Early and accurate diagnosis of SLE is crucial for optimal patient management. The 2019 EULAR/ACR classification criteria have improved diagnostic precision with a weighted scoring system for diverse disease manifestations. Therapy of neuropsychiatric lupus focuses on symptom control and causal treatment, considering anti-inflammatory action or counteracting ischemic incidents. It involves immunosuppressive agents and antiplatelet or anticoagulant substances. Non-pharmacological interventions and lifestyle modifications are also important. The dynamic criteria reflect ongoing advancements in understanding SLE, emphasizing continuous research and collaboration. Conclusions: The diagnosis of NPSLE requires excluding other causes of neuropsychiatric symptoms, such as infections, endocrine disorders, or drug reactions. Diagnostic methods vary based on symptoms, including lumbar puncture, CSF analysis, EEG, cognitive function assessment, and MRI. The treatment of NPSLE focuses on symptom control and causal treatment, with therapy individualized based on symptom severity and patient burden

THE RELATION BETWEEN EMOTIONAL INTELLIGENCE AND INTERNET ADDICTION IN KATOWICE HIGH SCHOOL STUDENTS

Backgroud: Emotional intelligence (EI) is described as the capacity to be aware of, control, and express one\u27s emotions, and to handle interpersonal relationships judiciously and empathetically. It is considered as one of the most important predictors of success, quality of relationships, and overall happiness. Dynamically changing environment of the youth and young adults in recent years may influence their EI development, affecting their lives significantly. The purpose of this study was to analyse the way how the Internet is used by high school students, to determine the amount of time they spend on the Internet, identify the level of EI and to explore if there is any correlation between those factors. Subjects and methods: 1450 high school students from Katowice, at the age from 18 to 21 years took part in an anonymous survey consisting of three parts: The Trait Emotional Intelligence Questionnaire – Short Form (TEIQue-SF), Internet Addiction Test and authorial test giving information about the way of spending time online. The questionnaires were collected from May 2018 to January 2019. Results: 1.03% of the respondents fulfilled the Internet addiction criteria. Students at risk for addiction (33.5%) turned out to be a larger group. A statistically significant correlation between TEIQue-SF and Internet Addiction Test score (P<0.0001, r=-0.3308) was observed. Another significant correlation was found between TEIQue-SF score and amount of time spend on the Internet (p<0.0001, r=-0.162). Conclusion: A significant part of high school students used Internet excessively. Such behaviours were positively correlated with lower EI test results

New phosphorus analogs of bevirimat: synthesis, evaluation of anti-HIV-1 activity and molecular docking study

Since the beginning of the human immunodeficiency virus (HIV) epidemic, many groups of drugs characterized by diverse mechanisms of action have been developed, which can suppress HIV viremia. 3-O-(3′,3′-Dimethylsuccinyl) betulinic acid, known as bevirimat (BVM), was the first compound in the class of HIV maturation inhibitors. In the present work, phosphate and phosphonate derivatives of 3-carboxyacylbetulinic acid were synthesized and evaluated for anti-HIV-1 activity. In vitro studies showed that 30-diethylphosphonate analog of BVM (compound 14a) has comparable effects to BVM (half maximal inhibitory concentrations (IC50) equal to 0.02 μM and 0.03 μM, respectively) and is also more selective (selectivity indices: 3450 and 967, respectively). To investigate the possible mechanism of antiviral effect of 14a, molecular docking was carried out on the C-terminal domain (CTD) of HIV-1 capsid (CA)–spacer peptide 1 (SP1) fragment of Gag protein, designated as CTD-SP1, which was described as a molecular target for maturation inhibitors. Compared with interactions between BVM and the protein, an increased number of strong interactions between ligand 14a and protein, generated by the phosphonate group, was observed

The Use of GLP-1 Receptor Agonists in the Treatment of Obesity in Women with PCOS

Introduction and aim of study: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting young women. It is diagnosed in individuals who meet 2 of the following 3 criteria: hyperandrogenism, ovarian dysfunction or polycystic ovarian morphology on ultrasound. A common component of this disease is obesity that leads to many serious health complications. This review paper aims to discuss the use of glucagon-like peptide-1 (GLP-1) receptor agonists as a therapeutic option to treat obesity in female patients with PCOS. Materials and Methods: The authors conducted a comprehensive review of the literature available in databases: PubMed and Medline focusing on the terms “PCOS”, “GLP-1”, “obesity”. Results: The first-line treatment of metabolic disorders in the course of PCOS is lifestyle modification. In patients who do not achieve sufficient results pharmacotherapy is recommended. Therapy with GLP-1 receptor agonists shows beneficial effects not only on weight loss, but also on metabolic and endocrine disorders. Studies have proven the superiority of these medications over metformin in the treatment of obesity associated with PCOS. However, the simultaneous use of GLP-1 receptor agonists and metformin may be beneficial for the patients. Conclusions: GLP-1 receptor agonists appear to be a promising therapeutic option in obese women with PCOS according to safety profile and effectiveness proven in studies

Niespokrewnieni dawcy komórek macierzystych — motywacja i satysfakcja w procesie donacji komórek krwiotwórczych

Background. Poland has the most rapidly growing population of registered stem cell donors worldwide. The aim of the study was the analysis of motivation, ways of recruitment, major side effects and general satisfaction related to donation process among unrelated hematopoietic stem cell (HSC) donors at a major stem cell facility in Poland. Material and methods. The prospective study was based on data from online questionnaire completed by unrelated HSC donors — before and after donation. The study included 109 questionnaires completed prior to donation and 80 questionnaires completed after donation. Results. The wish to help others was motivation for registration in 84% of the donors. The most common recruitment site were local actions (49%), the Internet however has also become a major source of registration — 42% of donors were recruited through the Internet based service. The most common side effects or general discomforts related to donation as reported by donors were: G-CSF injections (45%) and duration of the procedure (29%) in the case of peripheral blood stem cell donors (PBSC) and in the case of bone marrow harvest in general anesthesia — weakness after donation (27%), duration of hospital stay (27%) as well as pain after intubation (18%). Pain related to G-CSF mobilization procedure was higher than that reported after bone marrow harvest (1.51 vs 0.67; p = 0,83). Only 6% PBSC donors regarded this pain as significant compared to 9% of marrow donors. Conclusion. The outcome of the study provides a positive overview of stem cell donation in Poland. Stem cell donors report satisfaction with information provided by health care personnel on recruitment, qualification and donation procedure, the procedure-related side effects and discomforts are few and the sense of contentment and satisfaction is high.Wstęp. W ostatnich latach polski rejestr niespokrewnionych dawców komórek krwiotwórczych był najszybciej rozwijającym się rejestrem w skali świata. Celem niniejszej pracy jest analiza procesu rekrutacji i pobierania komórek macierzystych od dawców. Analizę tę przeprowadzono w największym ośrodku pobierającym w Polsce — w Samodzielnym Publicznym Centralnym Szpitalu Klinicznym. Materiał i metody. Przeprowadzono badanie ankietowe online wśród niespokrewnionych dawców komórek krwiotwórczych przed donacją i po. Łącznie dawcy wypełnili 109 kwestionariuszy przed donacją i 80 kwestionariuszy po donacji. Wyniki. Chęć niesienia pomocy drugiemu człowiekowi była głównym powodem rejestracji dla 84% dawców. Najczęściej rekrutowano ich podczas lokalnych akcji (49% dawców) i przez Internet — poprzez kwestionariusze dostępne w sieci (42%). Najczęściej zgłaszanymi przez dawców niedogodnościami związanymi z pobraniem komórek były: konieczność wykonywania zastrzyków czynnika wzrostu granulocytów (45%) i czas trwania procedury (29%) — wśród dawców komórek krwiotwórczych z krwi obwodowej — oraz osłabienie po pobraniu (27%), konieczność pobytu w szpitalu (27%) i ból gardła po intubacji (18%) związane z pobraniem szpiku w znieczuleniu ogólnym. Natężenie bólu zgłaszanego przez dawców w trakcie pobrania komórek z krwi obwodowej było większe niż u dawców po pobraniu szpiku, ale nie była to różnica istotna statystycznie (1,51 vs 0,67; p = 0,83). Tylko 6% dawców komórek z krwi obwodowej uważało ten ból za istotny w porównaniu do 9% dawców, od których pobierano szpik. Wnioski. Wyniki pracy pokazują pozytywny obraz donacji komórek krwiotwórczych. Zadowolenie z otrzymanych informacji w trakcie rekrutacji, kwalifikacji i donacji, mała liczba niekorzystnych doświadczeń dawców oraz ogólne zadowolenie z przebiegu donacji przyczyniają się do kształtowania pozytywnego obrazu dawstwa i przeszczepiania szpiku w Polsce