Kecenderungan Perilaku Berwirausaha Warga Belajar terhadap Pelatihan Sablon di Pkbm Cahaya Ilmu Kelurahan Tuah Karya Kecamatan Tampan Kota Pekanbaru

This research is motivated by several phenomena that occur in theenvironment PKBM Light Sciences and based on the results of previous observations,which are both associated with a trend towards behavioral entrepreneurship trainingresidents to learn screen printing. Therefore the aim of this study was to determine thebehavior tendencies of entrepreneurship learners to the training of screen printing inPKBM Cahaya Ilmu Kelurahan Tuah Karya Kecamatan Tampan Kota Pekanbaru. Thisresearch is a descriptive qualitative approach. This research was conducted at PKBMCahaya Ilmu Kelurahan Tuah Karya Kecamatan Tampan Kota Pekanbaru. Subjects ofthis study consisted of five persons, namely 2 a key informant who is a national study,two people to become informants who are citizens studying control and one informantobserver are tutor. Data were collected by observation, interview and documentation.The research data that has been analyzed by the data analysis technique based on theopinion of Miles and Huberman, namely data reduction, data model and conclusion.Based on the research method is run, it is the conclusion of this study is the Personalityresidents learned that is well established, the demonstrated high initiative in learningstudied. Citizen have a good relationship and to establish good communication alsowith fellow learners and tutors. Residents learned already can prepare marketingstrategies printing results that are ready to be traded in the market screening. Citizenlearning can organize activities screening become an entrepreneurial interest in themarket. But people do not learn they are better equipped to manage an entrepreneurialscreening. Residents learn yet have adequate capital and yet they are better equipped tomanage the finances

External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction

Background: The early non-invasive discrimination of Type 2 versus Type 1 Myocardial Infarction (T2MI, T1MI) is a major unmet clinical need. We aimed to externally validate a recently derived clinical score (Neumann) combing female sex, no radiating chest pain, and high-sensitivity cardiac troponin I (hs-cTnI) concentration ≤40.8 ng/L. Methods: Patients presenting with acute chest discomfort to the emergency department were prospectively enrolled into an international multicenter diagnostic study. The final diagnoses of T2MI and T1MI were centrally adjudicated by two independent cardiologists using all information including cardiac imaging and serial measurements of hs-cTnT/I according to the fourth universal definition of MI. Model performance for T2MI diagnosis was assessed by formal tests and graphical means of discrimination and calibration. Results: Among 6684 enrolled patients, MI was the adjudicated final diagnosis in 1079 (19%) patients, of which 242 (22%) had T2MI. External validation of the Neumann Score showed a moderate discrimination (C-statistic 0.67 (95%CI 0.64–0.71)). Model calibration showed underestimation of the predicted probabilities of having T2MI for low point scores. Model extension by adding the binary variable heart rate >120/min significantly improved model performance (C-statistic 0.73 (95% CI 0.70–0.76, p 120/min improved the model’s performance

STAT5 Is an Ambivalent Regulator of Neutrophil Homeostasis

BACKGROUND: Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5-/- mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-CSF, allowing myeloid progenitors to overcompensate for their intrinsic survival defect. However, when injected with pro-inflammatory cytokines, mutant mice cannot further increase neutrophil production, display a severe deficiency in peripheral neutrophil survival, and are therefore unable to maintain neutrophil homeostasis. In wild-type mice, inflammatory stimulation induces rapid STAT5 degradation in LECs, G-CSF production by LECs and other cell types, and then sustained mobilization and expansion of long-lived neutrophils. CONCLUSION: We conclude that STAT5 is an ambivalent factor. In cells of the granulocytic lineage, it exerts an antiapoptotic function that is required for maintenance of neutrophil homeostasis, especially during the inflammatory response. In LECs, STAT5 negatively regulates granulopoiesis by directly or indirectly repressing G-CSF expression. Removal of this STAT5-imposed brake contributes to induction of emergency granulopoiesis.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Analysis of the seasonal variation in biochemical composition of

The biochemical composition of Daphnia magna Straus, the dominant planktonic crustacean of the waste stabilisation pond of Differdange (Grand-Duchy of Luxembourg), was quantitatively determined from October 1993 to July 1994. Over the sampling period, the average composition (mean ± S.D.) was 271 ± 64 mg proteins.g-1 dry weight (DW), 100 ± 28 mg lipids.g-1 (DW), 96 ± 58 μg carotenoids.g-1 (DW), 49 ± 14 mg chitin.g-1 (DW) and 125 ± 78 mg ash.g-1 (DW). The seasonal variations of the biochemical composition were related to several ecological variables (water temperature, dissolved oxygen concentration, pH, water transparency, chlorophyll a concentration and D. magna biomass). The chitin content was positively correlated to the water temperature as a result of the strong influence of this later variable on the moulting rate of the daphnids and, subsequently, on the chitin synthesis by these organisms. The carotenoid content was positively correlated to the water transparency as a result of their photoprotective role in daphnids. The fluctuations of the lipid, protein and ash levels in D. magna depended to the food availability. Despite a seasonal variation in the biochemical composition, D. magna appeared to have adequate lipid and protein levels to be used in aquaculture. Its carotenoid content is similar to fish meals used to color salmonid flesh and these organisms could be used for this purpose. The prospect of using D. magna for chitin extraction is worth considering with respect to its significant chitin content, especially if highly valuable applications are aimed

Expression of c-inhibitor of apoptosis protein-2 in the sputum from asthmatic patients

peer reviewe

Anticoagulation in the Very Old: Does Age Matter?

Background: There is a 4.5% annual risk of a thromboembolic stroke in patients with atrial fibrillation (AF) and a CHADS2-VASC score 2 or greater. Among these patients, anticoagulation using Warfarin or a direct oral anticoagulant has been shown to reduce the risk of events by 45%. However, there has been some provider concern about the increased risk of bleeding while on anticoagulation in patients who are older, frailer, and have multiple comorbidities. Previous studies have suggested that anticoagulation is recommended in nearly all patients with a CHADS2-VASC score at 2 or greater. Understanding factors that make patients poor candidates for anticoagulation may help providers with their decision to start patients on therapy. This study attempted to identify characteristics or risk factors that affect anticoagulation treatment success among older patients at Pen Bay Medical Center (PBMC). Methods: Patients aged 70 and older treated with warfarin and managed by the Anticoagulation Services at PBMC were followed for 24 months. Data collected at enrollment and at every 6 months included patient demographics, clinical characteristics, and time in therapeutic range (TTR), a percentage of time that a patient’s International Normalized Ratio (INR) values were in range over a 6-month period, and the primary outcome of interest. TTR was dichotomized at the end of the study as in range (\u3e=60%) or out of range (\u3c60%). Chi-square tests of association were performed to compare characteristics between those in range at least 60% of the time vs. who were not at study end. A regression model is currently being developed in order to identify predictors of TTR in range/out of range. Results: This study enrolled 132 patients aged 70 and older seen at the Anticoagulation Services at PBMC over a 24-month period. Males were significantly more likely than females to be in range at least 60% of the time at study end (92% vs. 72%, respectively, p=0.004). There was no statistically significant difference in age category (p=0.74), mini Cognitive scores (p=0.26), Frailty scores (p=0.09), mobility scale (p=0.51), CHADS2-VASC (p=0.78), living arrangement (p=0.09), or alcohol use (p=0.06) between the two groups. Conclusions: Preliminary results from this analysis indicate that age and other factors among elderly patients, including frailty, cognitive ability, or mobility do not affect whether anticoagulation is successful at the end of a 24-month period. Further work is underway to develop a model to understand how these factors may interact with each other to predict anticoagulation treatment outcomes in this patient population

Impaired accumulation of granulocytes in the lung during ozone adaptation

peer reviewedRespiratory alterations induced by an acute exposure to ozone (O(3)) paradoxically resolve during multiday exposure. This adaptation is characteristically accompanied by a gradual attenuation of lung neutrophilia. As maintenance of neutrophilia at the site of inflammation is due to cytokine-mediated delayed neutrophil apoptosis, which is associated with reduced levels of Bax, a proapoptotic protein, we sought to determine whether defects in these mechanisms could account for O(3) adaptation. Lung granulocytes obtained at different time points from calves exposed to 0.75 ppm O(3) for 12 h/d for 7 consecutive days neither showed enhancement of survival nor Bax deficiency, when compared to blood granulocytes. To further investigate the effects of an exogenous oxidative stress on neutrophil survival, human granulocytes were treated with hydrogen peroxide alone, or in combination with granulocyte/macrophage colony-stimulating factor, an antiapoptotic cytokine. Both treatments led to rapid apoptosis associated with downregulation of Bcl-x(L) and Bcl-2, two antiapoptotic proteins. This study shows that O(3) adaptation is associated with a failure in the mechanisms leading to accumulation of neutrophils at the site of inflammation, and suggests that this defect is due to direct proapoptotic effects of exogenous oxidative stress on granulocyte

Foot progression angle estimation using a single foot-worn inertial sensor

Background: The foot progression angle is an important measure used to help patients reduce their knee adduction moment. Current measurement systems are either lab-bounded or do not function in all environments (e.g., magnetically distorted). This work proposes a novel approach to estimate foot progression angle using a single foot-worn inertial sensor (accelerometer and gyroscope). Methods: The approach uses a dynamic step frame that is recalculated for the stance phase of each step to calculate the foot trajectory relative to that frame, to minimize effects of drift and to eliminate the need for a magnetometer. The foot progression angle (FPA) is then calculated as the angle between walking direction and the dynamic step frame. This approach was validated by gait measurements with five subjects walking with three gait types (normal, toe-in and toe-out). Results: The FPA was estimated with a maximum mean error of ~ 2.6° over all gait conditions. Additionally, the proposed inertial approach can significantly differentiate between the three different gait types. Conclusion: The proposed approach can effectively estimate differences in FPA without requiring a heading reference (magnetometer). This work enables feedback applications on FPA for patients with gait disorders that function in any environment, i.e. outside of a gait lab or in magnetically distorted environments.</p

Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Objective: To determine matrix metalloproteinase-3 (MMP-3) serum levels in patients with rheumatic diseases and to study the relation between MMP-3 and C reactive protein (CRP) levels. Methods: MMP-3 serum levels were determined by enzyme linked immunosorbent assay (ELISA) in (a) patients with active inflammatory rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis, polymyalgia rheumatica, acute crystal arthritis, and ankylosing spondylitis; (b) patients with active inflammatory systemic diseases: cutaneo-articular or renal systemic lupus erythematosus (SLE), systemic sclerosis, and vasculitides; (c) patients with non-inflammatory rheumatic diseases: osteoarthritis and fibromyalgia; (d) critically ill patients without rheumatic diseases, representing an acute inflammatory control group; (e) healthy controls. Results: MMP-3 serum levels were significantly increased in patients with active RA, psoriatic arthritis, and polymyalgia rheumatica, whether treated or not by corticosteroids, and in female patients with acute crystal arthritis. MMP-3 serum levels were normal in steroid-free patients with active cutaneo-articular or renal SLE, systemic sclerosis, and vasculitides but were significantly increased in steroid treated patients. MMP-3 levels were normal in fibromyalgia, osteoarthritis, ankylosing spondylitis, and acute inflammatory controls. MMP-3 was significantly correlated with CRP in RA (r=0.5, p=0.0004) but not in any of the other disease groups. Conclusions: MMP-3 serum levels are increased in inflammatory rheumatic diseases characterised by joint synovitis, such as RA, polymyalgia rheumatica, psoriatic arthritis, and acute crystal arthritis—that is, whether the diseases are acute or chronic, erosive or not. They are normal in SLE, systemic sclerosis, and vasculitides as well as in non-rheumatic inflammatory controls, but are significantly increased by steroids. These data strongly suggest that serum MMP-3 reflects synovial inflammation