Transnational Surfistas and the Development of Nicaragua’s Emerald Coast

This article weaves together data from the Nicaraguan Institute of Tourism (INTUR), online mainstream media sources, and surfing magazines, to tell the story of the development of the Emerald Coast, a historically overlooked periphery in southwestern Nicaragua that evolved into one of the country’s most high-profile and sought-after tourism destinations. The argument is that it is impossible to effectively explain the development of the Emerald Coast without first understanding the role surfing played in this phenomenon. This also serves to contextualize these foreign surfers as part of another wave of transnational engagement with Nicaragua, a country that has long been impacted by foreign actors from the United States and Europe. The convergence of opportunity – cultural, economic, and political forces – and environment facilitated the rise of Nicaragua’s surf tourism industry, which in turn engendered subsequent forms of leisure tourism. Over the course of three decades, this new industry shifted the economic focus of Nicaragua, as tourism became the leading contributor, in terms of revenue, to Nicaragua’s overall Gross Domestic Product (GDP). This article places foreign surfers at the center of this phenomenon by telling the story of the development and evolution of the Emerald Coast through the lens of surfing

Empire at Play: The United States’ Cultural Influence on Nicaragua’s National Sports’ Identity

‘Empire at Play’ seeks to contextualize the inception of a Nicaraguan surfing subculture in the first decade of the twenty-first century by situating it within the broader scope of the United States’ influence on Nicaragua’s sporting history. By weaving together primary and secondary sources, as well as oral histories from expatriate surfers, Nicaraguan nationals, and members from the local indigenous communities, this article shows how international actors from the United States introduced Nicaragua to three of their major sports: baseball, boxing, and surfing—all of which became part of Nicaragua’s cultural identity. As these three sports grew in popularity domestically, so too did the infrastructure capable of hosting major international events, subsequently garnering international recognition as authentically Nicaraguan sports. While these activities are merely extracurricular in and of themselves, examining their proliferation as part of the expansion of American empire in the twentieth century helps to underscore the varying forms of American imperialism that facilitated each sport’s introduction and popularization—surfing being the most recent of the three

Hα star formation main sequence in cluster and field galaxies at z ∼ 1.6

We calculate Hα-based star formation rates and determine the star formation rate–stellar mass relation for members of three Spitzer Adaptation of the Red-Sequence Cluster Survey (SpARCS) clusters at z ∼ 1.6 and serendipitously identified field galaxies at similar redshifts to the clusters. We find similar star formation rates in cluster and field galaxies throughout our range of stellar masses. The results are comparable to those seen in other clusters at similar redshifts, and consistent with our previous photometric evidence for little quenching activity in clusters. One possible explanation for our results is that galaxies in our z ∼ 1.6 clusters have been accreted too recently to show signs of environmental quenching. It is also possible that the clusters are not yet dynamically mature enough to produce important environmental quenching effects shown to be important at low redshift, such as ram-pressure stripping or harassment

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke: Clinical and genomic study of nonsmokers with oral tongue cancer

Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use

The Distribution of Prion Protein Allotypes Differs Between Sporadic and Iatrogenic Creutzfeldt-Jakob Disease Patients

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent of the human prion diseases, which are fatal and transmissible neurodegenerative diseases caused by the infectious prion protein (PrP(Sc)). The origin of sCJD is unknown, although the initiating event is thought to be the stochastic misfolding of endogenous prion protein (PrP(C)) into infectious PrP(Sc). By contrast, human growth hormone-associated cases of iatrogenic CJD (iCJD) in the United Kingdom (UK) are associated with exposure to an exogenous source of PrP(Sc). In both forms of CJD, heterozygosity at residue 129 for methionine (M) or valine (V) in the prion protein gene may affect disease phenotype, onset and progression. However, the relative contribution of each PrP(C) allotype to PrP(Sc) in heterozygous cases of CJD is unknown. Using mass spectrometry, we determined that the relative abundance of PrP(Sc) with M or V at residue 129 in brain specimens from MV cases of sCJD was highly variable. This result is consistent with PrP(C) containing an M or V at residue 129 having a similar propensity to misfold into PrP(Sc) thus causing sCJD. By contrast, PrP(Sc) with V at residue 129 predominated in the majority of the UK human growth hormone associated iCJD cases, consistent with exposure to infectious PrP(Sc) containing V at residue 129. In both types of CJD, the PrP(Sc) allotype ratio had no correlation with CJD type, age at clinical onset, or disease duration. Therefore, factors other than PrP(Sc) allotype abundance must influence the clinical progression and phenotype of heterozygous cases of CJD

The Politics of Waves: A Transnational and Cultural Surfing History of Popoyo, Nicaragua

During the 1970s and 1980s, as surfers were carving out new international surf spaces around the globe, Nicaragua was on a much different trajectory—one that engendered the Sandinista guerrilla insurgency that deposed a four-decade-long, US-backed dictatorship in 1979. In response, the United States waged a decade-long, low-intensity counterinsurgency against the Sandinista government. While other surfing destinations were growing in popularity, notably neighboring Costa Rica, Nicaragua was, by most accounts, considered off-limits due to the conflict. In 1990, a watershed moment fostered an environment conducive to international tourism and foreign investment. The election of Violeta Barrios Torres de Chamorro ushered in a time of peace unseen for decades. Chamorro’s embrace of market-driven economics created a scenario welcoming for international visitors and their foreign capital. A perhaps unforeseen beneficiary of these policies were surfers, who started gravitating to the once rural peripheries of southwestern Nicaragua. This radically changed the economic and cultural character of these historically indigenous communities. Over the course of three decades, surfing and its subculture permeated virtually all parts of these coastal pueblos, resulting in a profound and largely irreversible sociocultural and economic transformation. This dissertation places surfers and surfing at the center of this phenomenon, tracing the evolution of the Popoyo area, and the Tola Municipality more broadly, from an undeveloped stretch of Pacific coastline to an international epicenter for surf tourism and expatriate communities