Broadband in rural and remote areas: the impact of Scottish policy initiatives

The ability to participate in the Internet-based economy that is emerging requires access to broadband. However, in many countries, 'digital divides' occur, with those in geographically remote and rural areas being particularly disadvantaged. Through focusing on rural and remote Scotland, the paper identifies three different categories of policy initiatives that have been adopted and their interaction with broader UK and industry wide developments. Whilst these initiatives have encouraged the adoption of broadband, it is argued that UK initiatives are creating a new series of challenges to the adoption of broadband

Hydraulics are a first order control on CO2 efflux from fluvial systems

Evasion of carbon dioxide (CO2) from fluvial systems is now recognized as a significant component of the global carbon cycle. However the magnitude of, and controls on, this flux remain uncertain and improved understanding of both are required to refine global estimates of fluvial CO2 efflux. CO2 efflux data show no pattern with latitude suggesting that catchment biological productivity is not a primary control and that an alternative explanation for inter-site variability is required. It has been suggested that increased flow velocity and turbulence enhance CO2 efflux, but this is not confirmed. Here, using contemporaneous measurements of efflux (range: 0.07 – 107 µmol CO2 m-2 s-1), flow hydraulics (mean velocity range: 0.03 – 1.39 m s-1) and pCO2 (range: 174 – 10712 µatm) at six sites, we find that flow intensity is a primary control on efflux across two climatically different locations (where pH is not a limiting factor) and that the relationship is refined by incorporating the partial pressure of CO2 (pCO2) of the water. A remaining challenge is how to upscale from point to reach or river basin level. Remote imaging or river surface may be worth exploring if subjectivity in interpreting surface state can be overcome

Adolescent Obesity in the United States: Facts for Policymakers

Adolescent obesity in the United States has many important implications for both the health and well-being of the individual and society. Specific negative impacts of obesity on health include increased susceptibility to a host of diseases, chronic health disorders, psychological disorders, and premature death, which in turn add billions of dollars in health care costs each year. Excess medical costs due to overweight adolescents are estimated at more than $14 billion per year. Furthermore, adolescent obesity affects our nation's ability to protect itself; more than a quarter of 17- to 24-year-olds are not fit to enroll in the military due to their weight. Adolescence is a crucial period for establishing healthy behaviors. Many of the habits formed during this developmental stage will last well into adulthood. Although obesity is a complex problem not yet fully understood by researchers, by addressing the known factors that contribute to obesity in adolescence, policymakers can help ensure a healthy and productive adulthood for our nation's youth. Obesity and poor nutrition — combined with mental health disorders and emotional problems, violence and unintentional injury, substance use, and reproductive health problems — form part of a complex web of potential challenges to adolescents' healthy emotional and physical development

Identifying ILI Cases from Chief Complaints: Comparing the Accuracy of Keyword and Support Vector Machine Methods

We compared the accuracy of two methods of identifying ILI cases from chief complaints. We found that a support vector machine method was more accurate than a keyword method

Development of a new scale to measure ambiguity tolerance in veterinary students

The ability to cope with ambiguity and feelings of uncertainty is an essential element of professional practice. Research with physicians has identified that intolerance of ambiguity or uncertainty is linked to stress and some authors have hypothesised that there could be an association between intolerance of ambiguity and burnout (e.g. Cooke et al 2013). We describe the adaptation of the TAMSAD (Tolerance of Ambiguity in Medical Students and Doctors) scale for use with veterinary students. Exploratory factor analysis supports a unidimensional structure for the Ambiguity tolerance construct. Although internal reliability of the 29 item TAMSAD scale is reasonable (α = 0.50), an alternative 27 item scale (drawn from the original 41 items used to develop TAMSAD) shows higher internal reliability for veterinary students (α = 0.67). We conclude that there is good evidence to support the validity of this latter TAVS (Tolerance of Ambiguity in Veterinary students) scale to study ambiguity tolerance in veterinary students

Two key events associated with a transposable element burst occurred during rice domestication

Transposable elements shape genome evolution through periodic bursts of amplification. In this study we exploited knowledge of the components of the mPing/Ping/Pong TE family in four rice strains undergoing mPing bursts to track their copy numbers and distribution in a large collection of genomes from the wild progenitor Oryza rufipogon and domesticated Oryza sativa (rice). We characterized two events that occurred to the autonomous Ping element and appear to be critical for mPing hyperactivity. First, a point mutation near the end of the element created a Ping variant ( Ping16A ) with reduced transposition. The proportion of strains with Ping16A has increased during domestication while the original Ping (Ping16G) has been dramatically reduced. Second, transposition of Ping16A into a Stowaway element generated a locus ( Ping16A_Stow ) whose presence correlates with strains that have high mPing copies. Finally, demonstration that Pong elements have been stably silenced in all strains analyzed indicates that sustained activity of the mPing/Ping family during domestication produced the components necessary for the mPing burst, not the loss of epigenetic regulation

The Epidemiology of Stargardt Disease in the United Kingdom

The authors thank the British Ophthalmological Surveillance Unit (BOSU) for the support received, as well as Mr Barnaby Foot, research coordinator for BOSU, for his help and advice on this project. The authors thank the following ophthalmologists who assisted with data collection for this study: N. Acharya, S. Anwar, V. Bansal, P.N. Bishop, D. Byles, J.S. Chawla, A. Churchill, M. Clarke, B. Dhillon, M. Ekstein, S. George, J. Gillian, J.T. Gillow, D. Gilmour, R. Gray, P.T.S. Gregory, R. Gupta, S.P. Kelly, I.C. Lloyd, A. Lotery, M. McKibbin, R. MacLaren, G. Menon, A.T. Moore, A. Mulvihill, Y. Osoba, R. Pilling, H. Porooshani, A. Raghu Ram, T. Rimmer, I. Russell-Eggitt, M. Sarhan, R. Savides, S. Shafquat, A. Smith, A. Tekriwal, P. Tesha, P. Watts.Peer reviewedPublisher PD