Cassini Observations of Saturn's Magnetospheric Cusp

The magnetospheric cusp is a funnel-shaped region where shocked solar wind plasma is able to enter the high latitude magnetosphere via the process of magnetic reconnection. The first in-situ analysis of the cusp region at Saturn is presented using data from the Cassini spacecraft, primarily from particle instruments and magnetic field observations. The analysis is presented in three sections. Firstly, two high-latitude spacecraft crossings are confirmed to be cusp observations by: (i) comparing the observed plasma with that of the magnetosheath and the adjacent magnetosphere, (ii) investigating the direction of the observed ions and (iii) analysing the composition of the plasma. The ion observations are shown to be a result of `bursty' reconnection occurring at the dayside magnetopause. The field-aligned distances to the reconnection site are calculated from the observed energy-pitch angle dispersions. Secondly, all the observations of the cusp are presented for the high latitude spacecraft orbits between 2007 and 2013. A comparison of the observations is made as well as classification into groups due to varying characteristics. The locations of the reconnection site are calculated and compared to the literature. The events are also compared to solar wind propagation models to investigate any correlations. Finally, the magnetic field observations of the cusps are analysed, focusing on the diamagnetic depressions. This characteristic is not observed in all of the cusps, and the possible explanations for this are discussed. The data are subtracted from a magnetic field model, and the calculated magnetic pressure deficits are compared to the particle pressures. A high plasma pressure layer in the magnetosphere adjacent to the cusp is discovered to also depress the magnetic field. A summary of the consequences of this work is discussed specifically regarding the ongoing debate of the role of reconnection at Saturn and its influence on magnetospheric dynamics

Detection of negative pickup ions at Saturn's moon Dione

We investigate a possible negative ion feature observed by the Cassini Plasma Spectrometer (CAPS) during a flyby of Saturn's moon Dione that occurred on April 7, 2010. By examining possible particle trajectories, we find that the observed particles are consistent with negative pick‐up ions originating near the moon's surface. We find that the mass of the negative pick‐up ions is in the range of 15 – 25 u and tentatively identify this species as O‐, likely resulting from ionization and subsequent pick‐up from Dione's O2‐CO2 exosphere. Our estimates show that the negative ion density is ~3 x 10‐3 cm‐3. This is comparable to, but slightly smaller than, that previously reported for the density of O2+ pick‐up ions for the same flyby, indicating that negative pick‐up ions may represent a major loss channel for Dione's exosphere

A transient enhancement of Mercury's exosphere at extremely high altitudes inferred from pickup ions

Mercury has a global dayside exosphere, with measured densities of 10-2 cm-3 at ~1500 km. Here we report on the inferred enhancement of neutral densities (<102 cm-3) at high altitudes (~5300 km) by the MESSENGER spacecraft. Such high-altitude densities cannot be accounted for by the typical exosphere. This event was observed by the Fast-Imaging Plasma Spectrometer (FIPS), which detected heavy ions of planetary origin that were recently ionized, and "picked up" by the solar wind. We estimate that the neutral density required to produce the observed pickup ion fluxes is similar to typical exospheric densities found at ~700 km altitudes. We suggest that this event was most likely caused by a meteroid impact. Understanding meteoroid impacts is critical to understanding the source processes of the exosphere at Mercury, and the use of plasma spectrometers will be crucial for future observations with the Bepi-Colombo mission

A systematic review of the safety of lisdexamfetamine dimesylate

BACKGROUND: Here we review the safety and tolerability profile of lisdexamfetamine dimesylate (LDX), the first long-acting prodrug stimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). METHODS: A PubMed search was conducted for English-language articles published up to 16 September 2013 using the following search terms: (lisdexamfetamine OR lisdexamphetamine OR SPD489 OR Vyvanse OR Venvanse OR NRP104 NOT review [publication type]). RESULTS: In short-term, parallel-group, placebo-controlled, phase III trials, treatment-emergent adverse events (TEAEs) in children, adolescents, and adults receiving LDX were typical for those reported for stimulants in general. Decreased appetite was reported by 25-39 % of patients and insomnia by 11-19 %. The most frequently reported TEAEs in long-term studies were similar to those reported in the short-term trials. Most TEAEs were mild or moderate in severity. Literature relating to four specific safety concerns associated with stimulant medications was evaluated in detail in patients receiving LDX. Gains in weight, height, and body mass index were smaller in children and adolescents receiving LDX than in placebo controls or untreated norms. Insomnia was a frequently reported TEAE in patients with ADHD of all ages receiving LDX, although the available data indicated no overall worsening of sleep quality in adults. Post-marketing survey data suggest that the rate of non-medical use of LDX was lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations. Small mean increases were seen in blood pressure and pulse rate in patients receiving LDX. CONCLUSIONS: The safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants

Automated force-free flux rope identification

We describe a method developed to automatically identify quasi force‐free magnetotail flux ropes from in situ spacecraft magnetometer data. The method locates significant (greater than 1σ) deflections of the north‐south component of the magnetic field coincident with enhancements in other field components. The magnetic field data around the deflections are then processed using Minimum Variance Analysis (MVA) to narrow the selection down to those that exhibit the characteristics of flux ropes. The subset of candidates that fulfills the requirements are then compared to a cylindrical, linear (constant‐α) force‐free model. Those that can be well approximated as force free are then accepted. The model fit also provides a measure of the physical parameters that describe the flux rope (i.e., core field and radius). This process allows for the creation of a repeatable, consistent catalog of flux ropes. Automation allows a greater volume of data to be covered, saving time and allowing the exploration of potential selection biases. The technique is applied to MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) magnetometer data in the Hermean magnetotail and successfully locates flux ropes, some of which match previously known encounters. Assumptions of the method and potential future applications are discussed

Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+

The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the pi- pi- pi+ final state using a 190 GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data show a significant natural parity exchange production of a resonance with spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The resonant nature of this wave is evident from the mass-dependent phase differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2 is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged; version 3 updated authors, text shortened, data unchange

The Hide-and-Seek of Grain Boundaries from Moire Pattern Fringe of Two-Dimensional Graphene

Grain boundaries (GBs) commonly exist in crystalline materials and affect various properties of materials. The facile identification of GBs is one of the significant requirements for systematical study of polycrystalline materials including recently emerging two-dimensional materials. Previous observations of GBs have been performed by various tools including high resolution transmission electron microscopy. However, a method to easily identify GBs, especially in the case of low-angle GBs, has not yet been well established. In this paper, we choose graphene bilayers with a GB as a model system and investigate the effects of interlayer rotations to the identification of GBs. We provide a critical condition between adjacent moire fringe spacings, which determines the possibility of GB recognition. In addition, for monolayer graphene with a grain boundary, we demonstrate that low-angle GBs can be distinguished easily by inducing moire patterns deliberately with an artificial reference overlayopen0

Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major histocompatibility complex (MHC) class II molecules for CD4+ T cell inspection. However, the processing and presentation of proinsulin by antigen-presenting cells (APC) in humans is only partially understood. Here we demonstrate that the processing of proinsulin by B cell or myeloid dendritic cell (mDC1)-derived lysosomal cathepsins resulted in several proinsulin-derived intermediates. These intermediates were similar to those obtained using purified CatG and, to a lesser extent, CatD, S, and V in vitro. Some of these intermediates polarized T cell activation in peripheral blood mononuclear cells (PBMC) from T1D patients indicative for naturally processed T cell epitopes. Furthermore, CatG activity was found to be elevated in PBMC from T1D patients and abrogation of CatG activity resulted in functional inhibition of proinsulin-reactive T cells. Our data suggested the notion that CatG plays a critical role in proinsulin processing and is important in the activation process of diabetogenic T cells