Prognostic impact of hyperglycemia at onset of methicillin-sensitive Staphylococcus aureus bacteraemia

Previous reports have associated hyperglycemia to poor outcome among aged and comorbid Staphylococcus aureus bacteraemia (SAB) patients. However, the prognostic impact of hyperglycemia in SAB irrespective of age and underlying conditions including a diagnosis of diabetes has received little attention. The objective here was to evaluate the prognostic relevance of hyperglycemia at onset of methicillin-sensitive SAB (MS-SAB). It was a retrospective study of MS-SAB patients. Blood glucose was measured within 24 h of positive blood cultures. The patient cohort was analyzed en bloc and by categorization according to age, underlying conditions and a diagnosis of diabetes. Altogether 161 patients were identified. High initial blood glucose levels were observed among diabetics (p <0.001), patients with deep infections (p <0.05) and poor outcome at 28- or 90-days (p <0.05). Receiver operating characteristics presented the glucose cut-off level of 7.2 mmol/L as a significant predictor of mortality with an area under the curve of 0.63 (95% CI 0.52-0.75, p <0.05). Blood glucose ae7.2 mmol/L connected to higher 28- (9 vs. 20%, p <0.05) and 90-day (14 vs. 29%, p <0.01) mortality. In Cox proportional hazard regression the blood glucose cut-off value of 7.2 mmol/L significantly predicted 90-day mortality (HR, 2.12; 95% CI, 1.01-4.46; p <0.05). Among young and healthy non-diabetics the negative prognostic impact of high glucose was further accentuated (HR 7.46, p <0.05). High glucose levels had no prognostic impact among diabetics. Hyperglycemia at SAB onset may associate to poor outcome. The negative prognostic impact is accentuated among young and healthy non-diabetics.Peer reviewe

A search for the presence of magnetic fields in the two Supergiant Fast X-ray Transients IGR J08408-4503 and IGR J11215-5952

A significant fraction of high-mass X-ray binaries are supergiant fast X-ray transients (SFXTs). The prime model for the physics governing their X-ray behaviour suggests that the winds of donor OB supergiants are magnetized. To investigate if magnetic fields are indeed present in the optical counterparts of such systems, we acquired low-resolution spectropolarimetric observations of the two optically brightest SFXTs, IGR J08408-4503 and IGR J11215-5952 with the ESO FORS2 instrument during two different observing runs. No field detection at a significance level of 3sigma was achieved for IGR J08408-4503. For IGR J11215-5952, we obtain 3.2sigma and 3.8sigma detections (_hydr = -978+-308G and _hydr = 416+-110G) on two different nights in 2016. These results indicate that the model involving the interaction of a magnetized stellar wind with the neutron star magnetosphere can indeed be considered to characterize the behaviour of SFXTs. We detected long-term spectral variability in IGR J11215-5952, while for IGR J08408-4503 we find an indication of the presence of short-term variability on a time scale of minutes.Comment: 5 pages, 1 table, 7 figures, accepted for publication in MNRA

Bloodstream infections following different types of surgery in a Finnish tertiary care hospital, 2009-2014

The risk and outcome of bloodstream infections (BSIs) were evaluated following surgery. BSIs were identified in Helsinki University Hospital during 2009-2014 as part of the national surveillance. Of 711 BSIs identified, 51% were secondary and 49% primary. The rate was highest after cardiovascular surgery (8.7 per 1000 procedures) and lowest after gynaecologic (1.0 per 1000). Surgical site infection was the most frequent source of secondary BSIs (34%) and 45% of primary BSIs were central-line-associated. The 28-day case fatality ranged from zero in gynaecology/obstetrics to 21% in cardiovascular surgery. Besides BSIs related to surgical site infections, half of BSIs were primary, providing additional foci for prevention. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.Peer reviewe

An efficient algorithm for learning to rank from preference graphs

In this paper, we introduce a framework for regularized least-squares (RLS) type of ranking cost functions and we propose three such cost functions. Further, we propose a kernel-based preference learning algorithm, which we call RankRLS, for minimizing these functions. It is shown that RankRLS has many computational advantages compared to the ranking algorithms that are based on minimizing other types of costs, such as the hinge cost. In particular, we present efficient algorithms for training, parameter selection, multiple output learning, cross-validation, and large-scale learning. Circumstances under which these computational benefits make RankRLS preferable to RankSVM are considered. We evaluate RankRLS on four different types of ranking tasks using RankSVM and the standard RLS regression as the baselines. RankRLS outperforms the standard RLS regression and its performance is very similar to that of RankSVM, while RankRLS has several computational benefits over RankSVM

Spectroscopic signatures of magnetospheric accretion in Herbig Ae/Be stars. I. The case of HD101412

Models of magnetically-driven accretion and outflows reproduce many observational properties of T Tauri stars. This concept is not well established for the more massive Herbig Ae/Be stars. We intend to examine the magnetospheric accretion in Herbig Ae/Be stars and search for rotational modulation using spectroscopic signatures, in this first paper concentrating on the well-studied Herbig Ae star HD101412. We used near-infrared spectroscopic observations of the magnetic Herbig Ae star HD101412 to test the magnetospheric character of its accretion disk/star interaction. We reduced and analyzed 30 spectra of HD101412, acquired with the CRIRES and X-shooter spectrographs installed at the VLT (ESO, Chile). The spectroscopic analysis was based on the He I lambda 10,830 and Pa gamma lines, formed in the accretion region. We found that the temporal behavior of these diagnostic lines in the near-infrared spectra of HD101412 can be explained by rotational modulation of line profiles generated by accreting gas with a period P = 20.53+-1.68 d. The discovery of this period, about half of the magnetic rotation period P_m = 42.076 d previously determined from measurements of the mean longitudinal magnetic field, indicates that the accreted matter falls onto the star in regions close to the magnetic poles intersecting the line-of-sight two times during the rotation cycle. We intend to apply this method to a larger sample of Herbig Ae/Be stars.Comment: 8 pages, 1 table, 7 figures, accepted for publication in A&