1,574 research outputs found
The Cosmic Infrared Background at 1.25 and 2.2 Microns Using DIRBE and 2MASS: A Contribution Not Due to Galaxies?
Using the 2MASS second incremental data release and the zodiacal subtracted mission average maps of COBE/DIRBE, we estimate the cosmic background in the J (1.25 μm) and K (2.2 μm) bands using selected areas representing ~550 deg^2 of sky. We find a J background of 22.9 ± 7.0 kJy sr^(-1) (54.0 ± 16.8 nW m^(-2) sr^(-1)) and a K background of 20.4 ± 4.9 kJy sr^(-1) (27.8 ± 6.7 nW m^(-2) sr^(-1)). This large-scale study shows that the main uncertainty comes from the residual zodiacal emission. The cosmic background we obtain is significantly higher than integrated galaxy counts (3.6 ± 0.8 kJy sr^(-1) and 5.3 ± 1.2 kJy sr^(-1) for J and K, respectively), suggesting either an increase of the galaxy luminosity function for magnitudes fainter than 30 mag or the existence of another contribution to the cosmic background from primeval stars, black holes, or relic particle decay
Optical Spectroscopic Survey of High-latitude WISE-selected Sources
We report on the results of an optical spectroscopic survey at high Galactic latitude (|b| ≥ 30°) of a sample of WISE-selected targets, grouped by WISE W1 (λ_eff = 3.4 μm) flux, which we use to characterize the sources WISE detected. We observed 762 targets in 10 disjoint fields centered on ultraluminous infrared galaxy candidates using DEIMOS on Keck II. We find 0.30 ± 0.02 galaxies arcmin–2 with a median redshift of z = 0.33 ± 0.01 for the sample with W1 ≥ 120 μJy. The foreground stellar densities in our survey range from 0.23 ± 0.07 arcmin–2 to 1.1 ± 0.1 arcmin–2 for the same sample. We obtained spectra that produced science grade redshifts for ≥90% of our targets for sources with W1 flux ≥120 μJy that also had an i-band flux gsim 18 μJy. We used this for targeting very preliminary data reductions available to the team in 2010 August. Our results therefore present a conservative estimate of what is possible to achieve using WISE's Preliminary Data Release for the study of field galaxies
Galaxies behind the Galactic plane: First results and perspectives from the VVV Survey
Vista Variables in The Via Lactea (VVV) is an ESO variability survey that is
performing observations in near infrared bands (ZYJHKs) towards the Galactic
bulge and part of the disk with the completeness limits at least 3 mag deeper
than 2MASS. In the present work, we searched in the VVV survey data for
background galaxies near the Galactic plane using ZYJHKs photometry that covers
1.636 square degrees. We identified 204 new galaxy candidates by analyzing
colors, sizes, and visual inspection of multi-band (ZYJHKs) images. The galaxy
candidates colors were also compared with the predicted ones by star counts
models considering a more realistic extinction model at the same completeness
limits observed by VVV. A comparison of the galaxy candidates with the expected
one by Milennium simulations is also presented. Our results increase the number
density of known galaxies behind the Milky Way by more than one order of
magnitude. A catalog with galaxy properties including ellipticity, Petrosian
radii and ZYJHKs magnitudes is provided, as well as comparisons of the results
with other surveys of galaxies towards Galactic plane.Comment: 27 pages, 10 figures, 2 tables; in press at The Astronomical Journa
Caltech Faint Field Galaxy Redshift Survey IX: Source detection and photometry in the Hubble Deep Field Region
Detection and photometry of sources in the U_n, G, R, and K_s bands in a 9x9
arcmin^2 region of the sky, centered on the Hubble Deep Field, are described.
The data permit construction of complete photometric catalogs to roughly
U_n=25, G=26, R=25.5 and K_s=20 mag, and significant photometric measurements
somewhat fainter. The galaxy number density is 1.3x10^5 deg^{-2} to R=25.0 mag.
Galaxy number counts have slopes dlog N/dm=0.42, 0.33, 0.27 and 0.31 in the
U_n, G, R and K_s bands, consistent with previous studies and the trend that
fainter galaxies are, on average, bluer. Galaxy catalogs selected in the R and
K_s bands are presented, containing 3607 and 488 sources, in field areas of
74.8 and 59.4 arcmin^2, to R=25.5 and and K_s=20 mag.Comment: Accepted for publication in ApJS; some tables and slightly nicer
figures available at http://www.sns.ias.edu/~hogg/deep
Identification of novel subgroup a variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus
<b>BACKGROUND:</b>
The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycoprotein that result in a shift in the receptor usage and the cell tropism of the virus. The factors that influence the transition from subgroup A to subgroup C remain unclear, one possibility is that a selective pressure in the host drives the acquisition of mutations in the RBD, creating A/C intermediates with enhanced abilities to interact with the FeLV-C receptor, FLVCR. In order to understand further the emergence of FeLV-C in the infected cat, we examined primary isolates of FeLV-C for evidence of FeLV-A variants that bore mutations consistent with a gradual evolution from FeLV-A to FeLV-C.<p></p>
<b>RESULTS:</b>
Within each isolate of FeLV-C, we identified variants that were ostensibly subgroup A by nucleic acid sequence comparisons, but which bore mutations in the RBD. One such mutation, N91D, was present in multiple isolates and when engineered into a molecular clone of the prototypic FeLV-A (Glasgow-1), enhanced replication was noted in feline cells. Expression of the N91D Env on murine leukaemia virus (MLV) pseudotypes enhanced viral entry mediated by the FeLV-A receptor THTR1 while soluble FeLV-A Env bearing the N91D mutation bound more efficiently to mouse or guinea pig cells bearing the FeLV-A and -C receptors. Long-term in vitro culture of variants bearing the N91D substitution in the presence of anti-FeLV gp70 antibodies did not result in the emergence of FeLV-C variants, suggesting that additional selective pressures in the infected cat may drive the subsequent evolution from subgroup A to subgroup C.<p></p>
<b>CONCLUSIONS:</b>
Our data support a model in which variants of FeLV-A, bearing subtle differences in the RBD of Env, may be predisposed towards enhanced replication in vivo and subsequent conversion to FeLV-C. The selection pressures in vivo that drive the emergence of FeLV-C in a proportion of infected cats remain to be established
Modeling Amyloid Beta Peptide Insertion into Lipid Bilayers
Inspired by recent suggestions that the Alzheimer's amyloid beta peptide (A
beta) can insert into cell membranes and form harmful ion channels, we model
insertion of the 40 and 42 residue forms of the peptide into cell membranes
using a Monte Carlo code which is specific at the amino acid level. We examine
insertion of the regular A-beta peptide as well as mutants causing familial
Alzheimer's disease, and find that all but one of the mutants change the
insertion behavior by causing the peptide to spend more simulation steps in
only one leaflet of the bilayer. We also find that A-beta 42, because of the
extra hydrophobic residues relative to A-beta 40, is more likely to adopt this
conformation than A-beta 40 in both wild-type and mutant forms. We argue
qualitatively why these effects happen. Here, we present our results and
develop the hypothesis that this partial insertion increases the probability of
harmful channel formation. This hypothesis can partly explain why these
mutations are neurotoxic simply due to peptide insertion behavior. We further
apply this model to various artificial A-beta mutants which have been examined
experimentally, and offer testable experimental predictions contrasting the
roles of aggregation and insertion with regard to toxicity of A-beta mutants.
These can be used through further experiments to test our hypothesis.Comment: 14 pages; 8 figures; 2nd revisio
Infrared luminosities of galaxies in the Local Volume
Near-infrared properties of 451 galaxies with distances D \leq 10 Mpc are
considered basing on the all-sky two micron survey (2MASS). A luminosity
function of the galaxies in the K-band is derived within [-25,-11] mag. The
local (D < 8 Mpc) luminosity density is estimated to be 6.8*10^8 L_sun/Mpc^3
that exceeds (1.5+-0.1) times the global cosmic density in the K-band. Virial
mass-to-K-luminosity ratios are determined for nearby groups and clusters. In
the luminosity range of (5*10^{10} - 2*10^{13})L_sun, the groups and clusters
follow the relation \lg(M/L_K) propto (0.27+-0.03) lg(L_K) with a scatter of
\~0.1 comparable to errors of the observables. The mean ratio ~=
(20-25) M_sun/L_sun for the galaxy systems turns out to be significantly lower
than the global ratio, (80-90)M_sun/L_sun, expected in the standard
cosmological model with the matter density of Omega_m =0.27. This discrepancy
can be resolved if most of dark matter in the universe is not associated with
galaxies and their systems.Comment: 15 pages, 7 figures. Astronomy Letters, submitte
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