A structural VAR model of the New Zealand business cycle

This paper develops a new open economy structural VAR model of the New Zealand economy. The model adopts techniques introduced by Cushman and Zha (1997) and Dungey and Pagan (2000) to identify international and domestic shocks and dynamic responses to these shocks in a small open economy. The international variables are block exogenous and the model includes restrictions on contemporaneous and lagged variables. Novel features include the introduction of an expanded set of domestic financial variables not captured in previous New Zealand VAR models, the use of a forward looking Taylor Rule to identify monetary policy, and the introduction of a climate variable to capture the impact of climatic conditions on the business cycle. Key results to emerge are the significant influence of international variables on the New Zealand business cycle, the importance of separately identifying import price and export price shocks, and the significant influence of climate.Open economy; structural VAR models; business cycles; climate; commodity prices; international linkages; financial conditions.

Chikungunya Occurrence among a Religious Missions Trip to Haiti in the Summer of 2014 and Implications for Community Health

As global travel becomes more common, the risk of spreading infectious diseases is increasing. Vectors too are spreading and becoming invasive species in environmental niches where they had previously been absent. The potential continues to grow for people to bring back diseases and infect local naive insect populations, which over time will increase the likelihood of the disease transmission occurring locally. This article evaluates the impact of a mission’s trip to Haiti and the return to a region of the United States that just recently became invaded by Aedes aegypti. The attack rate among the missionaries was approximately 20% (n=2), but this brings into question precautions that missionaries and other travelers will want to take upon return from tropical regions with endemic vector borne disease. Providers as well as travel clinics should educate patients regarding their viremic period and the potential to bring back diseases with them. While it would take hundreds of people to be viremic and to be bitten by the naive vector to establish local transmission, the preventative action is minor and would require travelers from endemic areas to continue to apply insect repellant for 7 days after return from an endemic region

Periodontal-Systemic Disease Education in United States Dental Hygiene Programs

The relationship between periodontal disease and systemic disease has gained much attention in recent years in the dental profession and from national health care agencies. Two third-party providers are now modifying their dental reimbursements for patients who have periodontal disease and are pregnant or have cardiovascular disease. However, there are few reports in the dental or dental hygiene literature about how students are taught this information and how it is incorporated into the didactic and clinical aspects of the curriculum. A thirty-item survey and cover letter on these subjects were emailed to the directors of the 286 accredited dental hygiene programs in the United States in 2007. The response rate was 63 percent. According to these responses, the three most emphasized topics regarding oral-systemic disease are diabetes, tobacco use, and cardiovascular disease. Most programs (90 percent) use journal articles for instructional content, and 87 percent use the American Academy of Periodontology website for reference. Only 4 percent have content taught jointly with nursing, medical, or allied health students. The majority of directors (87 percent) indicated they could use more evidence-based educational materials to help teach the concepts to students. Only 9 percent of survey respondents thought that nurses and physicians are knowledgeable about the relationship of oral health to systemic disease. The findings indicate that dental hygiene program directors are confident about the education on oral-systemic content provided to their dental hygiene students, but would like additional evidence-based materials to help their students learn this topic

Geometric anomaly detection in data

This paper describes the systematic application of local topological methods for detecting interfaces and related anomalies in complicated high-dimensional data. By examining the topology of small regions around each point, one can optimally stratify a given dataset into clusters, each of which is in turn well-approximable by a suitable submanifold of the ambient space. Since these approximating submanifolds might have different dimensions, we are able to detect non-manifold like singular regions in data even when none of the data points have been sampled from those singularities. We showcase this method by identifying the intersection of two surfaces in the 24-dimensional space of cyclo-octane conformations, and by locating all the self-intersections of a Henneberg minimal surface immersed in 3-dimensional space. Due to the local nature of the required topological computations, the algorithmic burden of performing such data stratification is readily distributable across several processors

Plant-forward diets and the social cultural milieu

Humanity’s window for climate action is closing rapidly (Tollefson, 2022). Given the ecological footprint associated with animal husbandry, scholars and non-governmental organisations have called for a transition to a more sustainable food system: an increased focused on plant-derived proteins (Clark et al., 2022; Willett et al., 2019). Such a transformation will require the collaboration of many actors both in- and outside of academia (e.g., social scientists, food technologists, businesspeople, and advocates). The field of Psychology has a unique role to play in studying human behaviour and cognition as it pertains to societal eating norms and the acceptance of plant-forward diets. Research of this kind has demonstrated that decisions to forgo animal-derived foods constitute a social eating norm violation and as such ought to be understood against the wider context in which they exist. Indeed, food-related decision-making occurs at various levels of society and food systems – including at the micro- (e.g., an individual’s own attitudes, motivations, and capabilities), meso- (e.g., family roles, relational dynamics) and distal-level (e.g., societal, and cultural norms around food; Boulet et al., 2021). Yet, to the authors knowledge, there is limited psychological literature that has considered these processes as they relate to plant-forward diets, specifically. Accordingly, the current thesis presents a rich exploration into the influence that one’s social-cultural milieu has on their food-related cognitions and decision making as they pertain to plant-forward eating. Study 1 employed smartphone-based experience sampling methodology and engaged in a micro-level analysis, investigating an individual’s commitment to reducing their meat consumption as influences by the experience of social support. In summary, we were unable to demonstrate the facilitative effects of social support in study 1. The results of this study highlighted the need to differentiate between types of social support (incl. structural, functional, and enacted means of support) and prompted a progression of our research focus: a move from studying food decision-making at the micro- to the meso-level. Study 2 and 3 employed a mix of survey and experience-sampling methodology with an elevated focus on the meso-level (i.e., the household), where we considered the influence of one’s primary social units (i.e., family members and romantic partners) on decisions pertaining to plant-forward diets. Here we demonstrated that micro-level food decision-making takes place within the broader context of intra-family negotiations and is subject to the established leadership style and emotional connection of the relationship. Finally, study 4 and 5 considered the intergroup and social-cultural context of plant-forward diets at the distal-level. Specifically, we employed a mix of survey methodology, text, and behaviour analytics to investigate the collective identity and ideological motivations of individuals actively engaged in overt antagonism or opposition towards vegan ideology. Together, this body of research advances current knowledge of the social and cultural milieu of plant-forward by demonstrating how decisions around plant-forward diets depend upon the relational climate of cohabiting units and highlighting the importance of identity and inter-group processes in the wider societal debate about sustainable diets

Netrin-3: Tracking the Elusive Antimitotic Signal on the Western Frontier

Netrin-3 is a guidance protein expressed throughout the animal kingdom, and involved in the development of branched structures such as the nervous system, lung, and mammary gland. We have previously shown that peptides derived from this protein serve as chemorepellents and mitotic inhibitors in Tetrahymena thermophila. Our previous work shows that Tetrahymena synthesize and secrete a netrin-3-like protein, as detected by ELISA. In this study, we find that a netrin-3-like protein is present in whole cell extract and secreted protein, as detected by Western blotting. A protein of approximately 48 kD is consistently detected in our Western blots. In addition, we often detect a protein of 52 kD, which may be the netrin-1-like protein of Tetrahymena that we have previously described. Further studies will enable us to determine whether the 52-kD protein is indeed the netrin-1 like protein of Tetrahymena

Netrin-3 Signals Through Serine Phosphorylation in Tetrahymena thermophila

The netrin family of proteins are structurally related to laminin and, while first discovered in the nematode Caenorhabditis elegans, are now known to be present in species throughout the animal kingdom, including humans. These proteins also have a wide variety of roles that include inhibition of apoptosis, chemorepulsion, and axonal guidance. Due to the results of previous studies involving netrin-1 in vertebrate systems, the current prevailing assumption is that netrins, when acting as chemorepellents, signal using tyrosine kinases. However, data that we gathered through phosphoserine-targeting ELISA assays and immunofluorescence microscopy demonstrates that the netrin-3 peptides signal Tetrahymena thermophila through serine phosphorylation instead, causing the ciliate protists to avoid netrin-3 peptides in response. Treatment with netrin-3 peptides also seems to cause mitotic inhibition in Tetrahymena, which can be reversed by addition of a serine kinase inhibitor. This new information suggests that netrin-3 may have physiological roles that have previously been unexplored

Radiological and clinical features of vein of Galen malformations.

BackgroundVein of Galen malformations (VOGMs) are rare and complex congenital arteriovenous fistulas. The clinical and radiological features of VOGMs and their relation to clinical outcomes are not fully characterized.ObjectiveTo examine the clinical and radiological features of VOGMs and the predictors of outcome in patients.MethodsWe retrospectively reviewed the available imaging and medical records of all patients with VOGMs treated at the University of California, San Francisco between 1986 and 2013. Radiological and clinical features were identified. We applied the modified Rankin Scale to determine functional outcome by chart review. Predictors of outcome were assessed by χ(2) analyses.ResultsForty-one cases were confirmed as VOGM. Most patients (78%) had been diagnosed with VOGM in the first year of life. Age at treatment was bimodally distributed, with predominantly urgent embolization at <10 days of age and elective embolization after 1 year of age. Patients commonly presented with hydrocephalus (65.9%) and congestive heart failure (61.0%). Mixed-type (31.7%) VOGM was more common in our cohort than purely mural (29.3%) or choroidal (26.8%) types. The most common feeding arteries were the choroidal and posterior cerebral arteries. Transarterial embolization with coils was the most common technique used to treat VOGMs at our institution. Functional outcome was normal or only mildly disabled in 50% of the cases at last follow-up (median=3 years, range=0-23 years). Younger age at first diagnosis, congestive heart failure, and seizures were predictive of adverse clinical outcome. The survival rate in our sample was 78.0% and complete thrombosis of the VOGM was achieved in 62.5% of patients.ConclusionsVOGMs continue to be challenging to treat and manage. Nonetheless, endovascular approaches to treatment are continuing to be refined and improved, with increasing success. The neurodevelopmental outcomes of affected children whose VOGMs are treated may be good in many cases

Racial differences in C-reactive protein levels during normal pregnancy

Characterization of serum C-Reactive Protein (CRP) levels in a diverse population of healthy pregnant women using a high sensitivity assay

Appearance normalization of histology slides

This paper presents a method for automatic color and intensity normalization of digitized histology slides stained with two different agents. In comparison to previous approaches, prior information on the stain vectors is used in the plane estimation process, resulting in improved stability of the estimates. Due to the prevalence of hematoxylin and eosin staining for histology slides, the proposed method has significant practical utility. In particular, it can be used as a first step to standardize appearance across slides and is effective at countering effects due to differing stain amounts and protocols and counteracting slide fading. The approach is validated against non-prior plane-fitting using synthetic experiments and 13 real datasets. Results of application of the method to adjustment of faded slides are given, and the effectiveness of the method in aiding statistical classification is shown