3 research outputs found
Epidemiology of Normal Pressure Hydrocephalus - Prevalence, Risk Factors, Diagnosis and Prognosis
The number of older persons and individuals with cognitive impairment is expected to increase dramatically in most parts of the world. It is therefore important to learn more about disorders that affect cognition. Idiopathic normal pressure hydrocephalus (iNPH) mainly occurs in older persons and symptoms include cognitive impairment, gait disturbance and urinary symptoms. The aim of this thesis was to examine various aspects regarding the epidemiology of iNPH.
The sample comprised data from the Gothenburg population studies. Study participants underwent comprehensive clinical and neuropsychiatric examinations between 1986 and 2009. iNPH was diagnosed in concordance with criteria from international consensus guidelines.
Study I: The prevalence of iNPH was higher than previously reported. More than one in twenty, among 80-year-olds, had signs and symptoms consistent with probable iNPH. Study II: Vascular risk factors and markers of cerebrovascular disease were associated with iNPH. Hypertension was related to an almost three-fold increased chance of having imaging signs of iNPH. For diabetes, it was more than four-fold. The strongest relation to iNPH was for cerebral white matter lesions, which were associated with a more than six-fold increased chance. Study III: More than one fifth of the sample had ventricular enlargement, defined by current cut-off values for Evans Index. In addition, men aged 80 years or more, had on average, values equal to or higher than what is currently considered pathological. Study IV: Persons who fulfilled criteria for probable iNPH had an almost four-fold increased risk of death. In those with radiological signs of iNPH, the risk of dementia was almost three-fold increased.
iNPH is probably more common than previously supposed. Many older persons have clinical and imaging signs consistent with iNPH. These findings are important considering that iNPH is a treatable disorder. Vascular factors are probably involved in the pathophysiology. Current cut- off values for ventricular enlargement, using Evans Index, ought to be reappraised in order to improve diagnostic possibilities. Untreated iNPH is associated with a poor prognosis with a high risk of death or dementia. Radiological signs of iNPH may have a greater prognostic importance than previously presumed
Nationwide prevalence of primary dystonia, progressive ataxia and hereditary spastic paraplegia
Objective: To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden. Methods: We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a diagnosis of primary dystonia, ataxia or HSP. We excluded patients with an additional diagnosis possibly indicating secondary causes, and determined the proportion of wrongly diagnosed patients at our own tertiary center by patient examination or chart review. We analyzed patients’ age and disorder subtypes, geographical distribution of patients within Sweden and the country of birth of all patients. Results: Nationwide, we identified 4239 patients (31.6% male) with a diagnosis of primary dystonia. Of 347 patients with dystonia at our center, 20.2% may have had a different final diagnosis. Extrapolation of this uncertainty rate to the national population resulted in a prevalence for primary dystonia of 35.1/100,000. There were 672 patients (49.6% male) with ataxia in NPR, and the diagnostic uncertainty rate among 81 patients in our center was 13.6% (prevalence 6.0/100,000). HSP was diagnosed in 235 patients nationwide (52.3% male, prevalence 2.4/100,000). Patients were distributed relatively evenly throughout the country. The proportions of patients with these diagnoses who were born outside of Sweden were lower (8.0–12.7%) than the proportion of all Swedish residents born abroad (15.9%). Conclusions: In this large, nationwide study, the prevalence of dystonia was high compared to previous studies, which partly may be explained by the high coverage of NPR