16 research outputs found
Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry
Background
The longâterm efficacy and safety of alcohol septal ablation (
ASA
) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the longâterm outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with
ASA
.
Methods and Results
We retrospectively evaluated consecutive patients enrolled in the Euroâ
ASA
registry (1427 patients) and identified 161 patients (53±13 years; 27% women) who were mildly symptomatic (New York Heart Association [
NYHA
] class
II
) preâ
ASA
. The median (interquartile range) followâup was 4.8 (1.7â8.5) years. The clinical outcome was assessed and compared with the ageâ and sexâmatched general population. The 30âday mortality after
ASA
was 0.6% and the annual allâcause mortality rate was 1.7%, which was similar to the ageâ and sexâmatched general population (
P
=0.62). A total of 141 (88%) patients had resting left ventricular outflow tract gradient at the last clinical checkup â€30 mm Hg. Obstruction was reduced from 63±32 to 15±19 mm Hg (
P
<0.01), and the mean
NYHA
class decreased from 2.0±0 to 1.3±0.1 (
P
<0.01); 69%, 29%, and 2% of patients were in
NYHA
class I,
II
, and
III
at the last clinical checkup, respectively.
Conclusions
Mildly symptomatic hypertrophic obstructive cardiomyopathy patients treated with
ASA
had sustained symptomatic and hemodynamic relief with a low risk of developing severe heart failure. Their survival is comparable to the general population.
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