1,149 research outputs found
Macrophages in homeostatic immune function
Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders
Spin-Valley Kondo Effect in Multi-electron Silicon Quantum Dots
We study the spin-valley Kondo effect of a silicon quantum dot occupied by electrons, with up to four. We show that the Kondo
resonance appears in the Coulomb blockade regimes, but not
in the one, in contrast to the spin-1/2 Kondo effect, which
only occurs at odd. Assuming large orbital level spacings, the
energy states of the dot can be simply characterized by fourfold spin-valley
degrees of freedom. The density of states (DOS) is obtained as a function of
temperature and applied magnetic field using a finite-U equation-of-motion
approach. The structure in the DOS can be detected in transport experiments.
The Kondo resonance is split by the Zeeman splitting and valley splitting for
double- and triple-electron Si dots, in a similar fashion to single-electron
ones. The peak structure and splitting patterns are much richer for the
spin-valley Kondo effect than for the pure spin Kondo effect.Comment: 8 pages, 4 figures, in PRB format. This paper is a sequel to the
paper published in Phys. Rev. B 75, 195345 (2007
Screening Breakdown on the Route toward the Metal-Insulator Transition in Modulation Doped Si/SiGe Quantum Wells
Exploiting the spin resonance of two-dimensional (2D) electrons in SiGe/Si
quantum wells we determine the carrier-density-dependence of the magnetic
susceptibility. Assuming weak interaction we evaluate the density of states at
the Fermi level D(E_F), and the screening wave vector, q_TF. Both are constant
at higher carrier densities n, as for an ideal 2D carrier gas. For n < 3e11
cm-2, they decrease and extrapolate to zero at n = 7e10 cm-2. Calculating the
mobility from q_TF yields good agreement with experimental values justifying
the approach. The decrease in D(E_F) is explained by potential fluctuations
which lead to tail states that make screening less efficient and - in a
positive feedback - cause an increase of the potential fluctuations. Even in
our high mobility samples the fluctuations exceed the electron-electron
interaction leading to the formation of puddles of mobile carriers with at
least 1 micrometer diameter.Comment: 4 pages, 3 figure
ZHP-3 Acts at Crossovers to Couple Meiotic Recombination with Synaptonemal Complex Disassembly and Bivalent Formation in C. elegans
Crossover recombination and the formation of chiasmata normally ensure the proper segregation of homologous chromosomes during the first meiotic division. zhp-3, the Caenorhabditis elegans ortholog of the budding yeast ZIP3 gene, is required for crossover recombination. We show that ZHP-3 protein localization is highly dynamic. At a key transition point in meiotic prophase, the protein shifts from along the length of the synaptonemal complex (SC) to an asymmetric localization on the SC and eventually becomes restricted to foci that mark crossover recombination events. A zhp-3::gfp transgene partially complements a null mutation and reveals a separation of function; although the fusion protein can promote nearly wild-type levels of recombination, aneuploidy among the progeny is high, indicating defects in meiotic chromosome segregation. The structure of bivalents is perturbed in this mutant, suggesting that the chromosome segregation defect results from an inability to properly remodel chromosomes in response to crossovers. smo-1 mutants exhibit phenotypes similar to zhp-3::gfp mutants at higher temperatures, and smo-1; zhp-3::gfp double mutants exhibit more severe meiotic defects than either single mutant, consistent with a role for SUMO in the process of SC disassembly and bivalent differentiation. We propose that coordination of crossover recombination with SC disassembly and bivalent formation reflects a conserved role of Zip3/ZHP-3 in coupling recombination with SC morphogenesis
Orbital mechanisms of electron spin manipulation by an electric field
A theory of spin manipulation of quasi-two-dimensional (2D) electrons by a
time-dependent gate voltage applied to a quantum well is developed. The
Dresselhaus and Rashba spin-orbit coupling mechanisms are shown to be rather
efficient for this purpose. The spin response to a perpendicular-to-plane
electric field is due to a deviation from the strict 2D limit and is controlled
by the ratios of the spin, cyclotron and confinement frequencies. The
dependence of this response on the magnetic field direction is indicative of
the strenghts of the competing spin-orbit coupling mechanisms
Elementary immunology: Na(+) as a regulator of immunity
The skin can serve as an interstitial Na(+) reservoir. Local tissue Na(+) accumulation increases with age, inflammation and infection. This increased local Na(+) availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na(+) availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na(+) levels bears broad therapeutic potential: increasing local Na(+) availability may help in treating infections, while lowering tissue Na(+) levels may be used to treat, for example, autoimmune and cardiovascular diseases
Lattice dynamics reveals a local symmetry breaking in the emergent dipole phase of PbTe
Local symmetry breaking in complex materials is emerging as an important
contributor to materials properties but is inherently difficult to study. Here
we follow up an earlier structural observation of such a local symmetry broken
phase in the technologically important compound PbTe with a study of the
lattice dynamics using inelastic neutron scattering (INS). We show that the
lattice dynamics are responsive to the local symmetry broken phase, giving key
insights in the behavior of PbTe, but also revealing INS as a powerful tool for
studying local structure. The new result is the observation of the unexpected
appearance on warming of a new zone center phonon branch in PbTe. In a harmonic
solid the number of phonon branches is strictly determined by the contents and
symmetry of the unit cell. The appearance of the new mode indicates a crossover
to a dynamic lower symmetry structure with increasing temperature. No
structural transition is seen crystallographically but the appearance of the
new mode in inelastic neutron scattering coincides with the observation of
local Pb off-centering dipoles observed in the local structure. The observation
resembles relaxor ferroelectricity but since there are no inhomogeneous dopants
in pure PbTe this anomalous behavior is an intrinsic response of the system. We
call such an appearance of dipoles out of a non-dipolar ground-state
"emphanisis" meaning the appearance out of nothing. It cannot be explained
within the framework of conventional phase transition theories such as
soft-mode theory and challenges our basic understanding of the physics of
materials
Sodium and its manifold impact on our immune system
The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate components of the immune system, potentially exacerbating certain autoimmune diseases, or alternatively, improving defenses against certain infections, such as cutaneous leishmaniasis. However, recent findings show that an experimental HSD may also aggravate other infections (e.g., pyelonephritis or systemic listeriosis). Here, we discuss the modulatory effects of a HSD on the microbiota, metabolic signaling, hormonal responses, local sodium concentrations, and their effects on various immune cell types in different tissues. We describe how these factors are integrated, resulting either in immune stimulation or suppression in various tissues and disease settings
Experimental probing of exchange interactions between localized spins in the dilute magnetic insulator (Ga,Mn)N
The sign, magnitude, and range of the exchange couplings between pairs of Mn
ions is determined for (Ga,Mn)N and (Ga,Mn)N:Si with x < 3%. The samples have
been grown by metalorganic vapor phase epitaxy and characterized by
secondary-ion mass spectroscopy; high-resolution transmission electron
microscopy with capabilities allowing for chemical analysis, including the
annular dark-field mode and electron energy loss spectroscopy; high-resolution
and synchrotron x-ray diffraction; synchrotron extended x-ray absorption
fine-structure; synchrotron x-ray absorption near-edge structure; infra-red
optics and electron spin resonance. The results of high resolution magnetic
measurements and their quantitative interpretation have allowed to verify a
series of ab initio predictions on the possibility of ferromagnetism in dilute
magnetic insulators and to demonstrate that the interaction changes from
ferromagnetic to antiferromagnetic when the charge state of the Mn ions is
reduced from 3+ to 2+.Comment: 12 pages, 14 figures; This version contains the detailed
characterization of the crystal structure as well as of the Mn distribution
and charge stat
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