4,443 research outputs found
Information Transfer Implies State Collapse
We attempt to clarify certain puzzles concerning state collapse and
decoherence. In open quantum systems decoherence is shown to be a necessary
consequence of the transfer of information to the outside; we prove an upper
bound for the amount of coherence which can survive such a transfer. We claim
that in large closed systems decoherence has never been observed, but we will
show that it is usually harmless to assume its occurrence. An independent
postulate of state collapse over and above Schroedinger's equation and the
probability interpretation of quantum states, is shown to be redundant.Comment: 13 page
Systematics of heavy-ion fusion hindrance at extreme sub-barrier energies
The recent discovery of hindrance in heavy-ion induced fusion reactions at
extreme sub-barrier energies represents a challenge for theoretical models.
Previously, it has been shown that in medium-heavy systems, the onset of fusion
hindrance depends strongly on the "stiffness" of the nuclei in the entrance
channel. In this work, we explore its dependence on the total mass and the
-value of the fusing systems and find that the fusion hindrance depends in a
systematic way on the entrance channel properties over a wide range of systems.Comment: Submitted to Phys. Rev. Lett., 5 pages, 3 figure
Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine program in Cambodia.
OBJECTIVE: Increasing access to highly active antiretroviral therapy to reach all those in need in developing countries (scale up) is slowly expanding to HIV-positive children, but documented experience remains limited. We aimed to describe the clinical, immunologic, and virologic outcomes of pediatric patients with >12 months of highly active antiretroviral therapy in 2 routine programs in Cambodia. METHODS: Between June 2003 and March 2005, 212 children who were younger than 13 years started highly active antiretroviral therapy. Most patients started a standard first-line regimen of lamivudine, stavudine, and nevirapine, using split adult fixed-dosage combinations. CD4 percentage and body weight were monitored routinely. A cross-sectional virologic analysis was conducted in January 2006; genotype resistance testing was performed for patients with a detectable viral load. RESULTS: Mean age of the subjects was 6 years. Median CD4 percentage at baseline was 6. Survival was 92% at 12 months and 91% at 24 months; 13 patients died, and 4 were lost to follow-up. A total of 81% of all patients had an undetectable viral load. Among the patients with a detectable viral load, most mutations were associated with resistance to lamivudine and non-nucleoside reverse-transcriptase inhibitor drugs. Five patients had developed extensive antiretroviral resistance. Being an orphan was found to be a predictor of virologic failure. CONCLUSIONS: This study provides additional evidence of the effectiveness of integrating HIV/AIDS care with highly active antiretroviral therapy for children in a routine setting, with good virologic suppression and immunologic recovery achieved by using split adult fixed-dosage combinations. Viral load monitoring and HIV genotyping are valuable tools for the clinical follow-up of the patients. Orphans should receive careful follow-up and extra support
Argon tagging of doubly transition metal doped aluminum clusters: The importance of electronic shielding
The interaction of argon with doubly transition metal doped aluminum clusters, AlnTM2+ (n = 1â18, TM = V, Nb, Co, Rh), is studied experimentally in the gas phase via mass spectrometry. Density functional theory calculations on selected sizes are used to understand the argon affinity of the clusters, which differ depending on the transition metal dopant. The analysis is focused on two pairs of consecutive sizes: Al6,7V2+ and Al4,5Rh2+, the largest of each pair showing a low affinity toward Ar. Another remarkable observation is a pronounced drop in reactivity at n = 14, independent of the dopant element. Analysis of the cluster orbitals shows that this feature is not a consequence of cage formation but is electronic in nature. The mass spectra demonstrate a high similarity between the size-dependent reactivity of the clusters with Ar and H2. Orbital interactions provide an intuitive link between the two and further establish the importance of precursor states in the reactions of the clusters with hydrogen
Electronic structure of triangular, hexagonal and round graphene flakes near the Fermi level
The electronic shell structure of triangular, hexagonal and round graphene
quantum dots (flakes) near the Fermi level has been studied using a
tight-binding method. The results show that close to the Fermi level the shell
structure of a triangular flake is that of free massless particles, and that
triangles with an armchair edge show an additional sequence of levels ("ghost
states"). These levels result from the graphene band structure and the plane
wave solution of the wave equation, and they are absent for triangles with an
zigzag edge. All zigzag triangles exhibit a prominent edge state at the Fermi
level, and few low-energy conduction electron states occur both in triangular
and hexagonal flakes due to symmetry reasons. Armchair triangles can be used as
building blocks for other types of flakes that support the ghost states. Edge
roughness has only a small effect on the level structure of the triangular
flakes, but the effect is considerably enhanced in the other types of flakes.
In round flakes, the states near the Fermi level depend strongly on the flake
radius, and they are always localized on the zigzag parts of the edge
Enhanced transmission versus localization of a light pulse by a subwavelength metal slit: Can the pulse have both characteristics?
The existence of resonant enhanced transmission and collimation of light
waves by subwavelength slits in metal films [for example, see T.W. Ebbesen et
al., Nature (London) 391, 667 (1998) and H.J. Lezec et al., Science, 297, 820
(2002)] leads to the basic question: Can a light be enhanced and simultaneously
localized in space and time by a subwavelength slit? To address this question,
the spatial distribution of the energy flux of an ultrashort (femtosecond)
wave-packet diffracted by a subwavelength (nanometer-size) slit was analyzed by
using the conventional approach based on the Neerhoff and Mur solution of
Maxwell's equations. The results show that a light can be enhanced by orders of
magnitude and simultaneously localized in the near-field diffraction zone at
the nm- and fs-scales. Possible applications in nanophotonics are discussed.Comment: 5 figure
On radiative corrections for unpolarized electron proton elastic scattering
A statistical analysis of the elastic unpolarized electron proton scattering
data shows that, at large momentum transfer, the size and the
dependence of the radiative corrections, as traditionally calculated and
applied, may induce large correlations of the parameters of the Rosenbluth fit,
which prevent a correct extraction of the electric proton form factor. Using
the electron QED structure (radiation) function approach the cross section of
elastic electron-proton scattering in leading and next-to leading
approximations is calculated and expressed as a correction to the Born cross
section, which is different for the electric and the magnetic contribution.
When properly applied to the data, it may give the solution to the problem of
the discrepancy of the polarized and unpolarized results on electron proton
scattering.Comment: 11 pagex, 5 figure
Psychometric properties of the Internalized Stigma of Mental Illness (ISMI-10) scale in a Dutch sample of employees with mental illness
BACKGROUND: Internalized stigma can have numerous negative effects on the well-being and employment of people with mental illness. Brief, valid, and reliable measures are needed to get a better understanding of self-stigmatization. The aim of this study is to translate the brief version of the Internalized Stigma of Mental Illness (ISMI-10) scale into a Dutch version and to assess the reliability and validity of this Dutch version in a sample of employees with mental illness. METHODS: The ISMI-10 was translated into Dutch using the forward-backward translation procedure. The sample consisted of 161 employees with mental illness. Internal consistency was evaluated and the retest reliability was tested with 68 respondents. The construct validity was evaluated by testing convergent and divergent validity. RESULTS: The Dutch ISMI-10 showed good internal consistency (αâ=â0.83) and good test-retest reliability (râ=â0.73). The Dutch ISMI-10 demonstrated excellent convergent validity; high correlations were found between the Dutch ISMI-10 and hope (r = -0.54), anxiety and depression (râ=â0.59), self-esteem (r = -0.56), and empowerment (râ=âââ0.59). Acceptable divergent validity was indicated; small correlations were found between the Dutch ISMI-10 and the physical functioning subscale (r = -0.27) and the role limitation due to physical problems subscale (r = -0.21), and medium correlations were found between the Dutch ISMI-10 and the general health subscale (r = -0.36). CONCLUSION: The Dutch ISMI-10 demonstrated adequate psychometric properties for assessing internalized stigma and can be used by researchers in Dutch speaking countries to get a better understanding of self-stigmatization among people with mental illness. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-04284-5
Secondary pulmonary alveolar proteinosis treated by lung transplant: A case report.
Pulmonary alveolar proteinosis (PAP) is a pulmonary disease characterized by disruption of surfactant homeostasis resulting in its accumulation in the alveoli. PAP is classically classified into three categories (Table 1): 1/primary (or autoimmune) with antibodies targeting the GM-CSF pathway, 2/secondary to another disease, typically a hematologic malignancy, and 3/genetic.
A 30 year-old woman received an allogenic hematopoietic stem cell transplantation (HSCT) after treatment for acute myeloid leukemia (AML). Within the first 6 months post HSCT, she developed an ocular, oral, digestive and hepatic graft-versus-host disease associated with a mixed ventilatory defect with a very severe obstructive syndrome and a severe CO diffusion impairment. High resolution computed tomography showed a classical "crazy paving" pattern. Aspect and differential cell count of BAL were normal. All microbiological samples remained culture negative. Histo-pathological analysis of transbronchial biopsies was unremarkable. Because of the severity of the respiratory insufficiency, open-lung biopsy (OBL) could not be performed. Despite multiple immunosuppressive therapies, lung function deteriorated rapidly; the patient also developed an excavated fungal lesion unresponsive to treatment. She underwent a bilateral lung transplant 48 months after HSCT. Histo-pathological analysis of explanted lungs showed obliterative bronchiolitis (OB), diffuse PAP and invasive cavitary pulmonary aspergillosis.
This case illustrates the simultaneous occurrence of OB, PAP and a fungal infection in a 30-year old female patient who underwent HSCT for acute myeloid leukemia (AML). To our knowledge this is the only documented case of PAP associated with OB treated by lung transplantation
An octacoordinated Nb atom in the NbAl<sub>8</sub>H<sub>8</sub><sup>+</sup> cluster
The NbAl8H8+ cluster was formed in a molecular beam and characterized by mass spectrometry and infrared spectroscopy. Density functional theory calculations show the lowest-energy isomer is a high symmetry singlet with the Nb atom placed at the center of a distorted hexagonal Al ring and coordinated by two AlH moieties, therefore exhibiting octacoordination. The unprecedented high-symmetric geometry is attributed to the 20 valence electrons; the central Nb atom adheres to the 18-electron rule and two additional delocalized electrons stabilize the hexagonal ring
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