Interpretable detection of unstable smart TV usage from power state logs

Power state logs from smart TVs are collected in order to construct a time-series representation of their usage. Time-series that belong to a TV exhibiting instability problems are classified accordingly. To do so, an automated feature extraction approach is used, together with linear classification methods in order to realise interpretable classification decisions. A normalized true positive rate of 0.84 ± 0.10 is obtained for the classification. The normalized true negative rate equals 0.80 ± 0.03. The final model returns a regularity statistic called the Approximate Entropy as its most important feature

Knowledge of the Concept Light Rail Transit: Determinants of the Cognitive Mismatch between Actual and Perceived Knowledge

peer reviewedThe Flemish public transport company “De Lijn” is planning the development of a new Light Rail network for medium range distance trips (10 to 40km). A challenge exists in the fact that the concept of Light Rail Transit (LRT) is relatively unknown in Flanders. Therefore this paper explores the knowledge of the concept ‘Light Rail Transit’ among the Flemish population. To investigate the knowledge, two separate binary logit models are estimated to explore the determinants of the overall actual knowledge and the determinants of a cognitive mismatch. The results show that age, sex, public transit use, household size, bicycle ownership and weekly number of shopping activities contribute significantly to the overall actual knowledge of the LRT-concept. Besides, cognitive mismatch is only significantly affected by age and gender. Moreover, the results reveal a serious lack of knowledge of the concept of LRT. Consequently, a successful implementation of the LRT-system in Flanders may be jeopardized and thus it is of crucial importance to raise the level of knowledge. A first option is knowledge acquisition based on experience of the transit network. In this view, it can be a good idea to develop “travel-one-day-for-free” marketing actions. Second, it is important to provide information to the travelers by contriving information campaigns based on the determinants identified by the models. How the campaigns should be constructed from an intrinsic and psychological point of view and deliberating between the methods of communication to reach the various target groups are some important considerations for further research

Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice

IntroductionNeuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone homeostasis. Indeed, osteoblasts and osteoclasts express NRP2 and male and female global Nrp2 knockout mice have a reduced bone mass accompanied by reduced osteoblast and increased osteoclast counts.MethodsWe first examined the in vitro effect of the calciotropic hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on Nrp2 transcription in osteoblasts. We next generated mice with a conditional deletion of Nrp2 in the osteoblast cell lineage under control of the paired related homeobox 1 promoter and mice with a conditional Nrp2 knockdown in osteoclasts under control of the Lysozyme promoter. Mice were examined under basal conditions or after treatment with either the bone anabolic vitamin D3 analog WY 1048 or with 1,25(OH)2D3.Results and discussionWe show that Nrp2 expression is induced by 1,25(OH)2D3 in osteoblasts and is associated with enrichment of the vitamin D receptor in an intronic region of the Nrp2 gene. In male mice, conditional deletion of Nrp2 in osteoblast precursors and mature osteoblasts recapitulated the bone phenotype of global Nrp2 knockout mice, with a reduced cortical cross-sectional tissue area and lower trabecular bone content. However, female mice with reduced osteoblastic Nrp2 expression display a reduced cross-sectional tissue area but have a normal trabecular bone mass. Treatment with the vitamin D3 analog WY 1048 (0.4 μg/kg/d, 14 days, ip) resulted in a similar increase in bone mass in both genotypes and genders. Deleting Nrp2 from the osteoclast lineage did not result in a bone phenotype, even though in vitro osteoclastogenesis of hematopoietic cells derived from mutant mice was significantly increased. Moreover, treatment with a high dose of 1,25(OH)2D3 (0.5 μg/kg/d, 6 days, ip), to induce osteoclast-mediated bone resorption, resulted in a similar reduction in trabecular and cortical bone mass. In conclusion, osteoblastic Nrp2 expression is suggested to regulate bone homeostasis in a sex-specific manner

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV

The dual role of weather forecasts on changes in activity-travel behavior

In previous studies, conflicting results could be found regarding the impact of weather forecasts on travel decisions, e.g. Khattak and De Palma (1997) found no significant effect of acquiring forecasted weather information on the probability of adapting mode and departure time, whereas the results reported by Hagens (2005), Niina (2009) and Kilpelainen and Summala (2007) indicated that weather forecast do play an important role. Therefore this paper investigates the changes in activity-travel behavior in response to weather forecasts. The data for this study is collected by means of a stated adaptation survey, which is both administered on the internet and via a traditional paper and pencil questionnaire. In total, 595 respondents completed the survey. To obtain an optimal correspondence between the true population and the sample weights are assigned to the observation. Results indicate that weather information plays a dual role. On the one hand people do alter their activity-travel behavior in response to weather information, albeit these changes are not as pronounced when compared to actual weather. On the other hand the extent (frequency and media type) to which people are exposed to these weather forecasts appears to play only a marginal role. This dual role weather information plays in this study appears to be supported by the conflicting international literature and therefore revealing the underlying psychological motivations to change one's activity-travel behavior is a key challenge for further research

Analyzing Access, Egress, and Main Transport Mode of Public Transit Journeys: Evidence from the Flemish National Household Travel Survey

peer reviewedThe primary objective of this paper is to explore the influence of socio-demographic and contextual variables on the multimodal character of public transit journeys. Accounting for multimodality in public transit journeys is important from a demand modeling point of view, especially in the assessment of new projected public transit infrastructure. To meet the objective, data from the national household travel survey of Flanders (Belgium) is analyzed. Based on 2,202 public transit journeys, the main public transit mode choice (bus/tram/metro or train) and access/egress mode choice are simultaneously estimated using a multinomial logit model, and by explicitly making a distinction between unimodal and multimodal transit journeys. The results indicate that various socio-demographical (e.g. age, gender, level of education, household income) and contextual factors (e.g. journey distance, journey motive, urbanization degree, car availability) significantly influence the joint decision process. Total journey distance and car availability are identified as the most important explanatory variables. In terms of model performance, the model appears to yield satisfactory predictions, justifying the integration of the model in more general demand modeling frameworks