Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8–7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues. © 1999 Cancer Research Campaig

Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives

Gastroenteropancreatic neuroendocrine tumours (GEP NETs) are rare tumours that present many clinical features

Narrative Personae and Visual Signs: Reading Leonard’s intimate photo-memoir. a/b: Auto/Biography Studies.

In this paper, I look at Joanne Leonard’s Being in Pictures and engage in a critical dialogue with an assemblage of visual and textual narratives that comprise her intimate photo memoir. In doing this I draw on Hannah Arendt’s take on narratives as tangible traces of uniqueness and plurality, political traits par excellence in the cultural histories of the human condition. Being aware of my role as a reader/viewer/interpreter of a woman artist’s auto/biographical narratives, I move beyond dilemmas of representation or questions of unveiling “the real Leonard”. The artist is instead configured as a narrative persona, whose narratives respond to three interrelated themes of inquiry, namely the visualization of spatial technologies, vulnerability and the gendering of memory. Key words: gendered memories, narrative persona, spatial technologies, photo memoir, vulnerabilit

Management and outcomes of atrial fibrillation in 241 healthy children and young adults: Revisiting lone atrial fibrillation-a multi-institutional PACES collaborative study

BACKGROUND: Atrial fibrillation (AF) in healthy children and young adults is rare. Risk of recurrence and treatment efficacy are not well defined. OBJECTIVE: The purpose of this study was to assess recurrence patterns and treatment efficacy in AF. METHODS: A retrospective multicenter cohort study including 13 congenital heart centers was facilitated by the Pediatric & Congenital Electrophysiology Society (PACES). Patients ≤21 years of age with documented AF from January 2004 to December 2018 were included. Demographics, family and clinical history, medications, electrophysiological study parameters, and outcomes related to the treatment of AF were recorded and analyzed. Patients with contributory diseases were excluded. RESULTS: In 241 subjects (83% male; mean age at onset 16 years), AF recurred in 94 patients (39%) during 2.1 ± 2.6 years of follow-up. In multivariable analysis, predictors of AF recurrence were family history in a first-degree relative(odds ratio [OR] 1.9; P = .047) and longer PR interval in sinus rhythm (OR 1.1 per 10 ms; P = .037). AF recurrence was similar whether patients began no treatment (39/125 [31%]), began daily antiarrhythmic therapy (24/63 [38%]), or had an ablation at any time (14/53 [26%]; P = .39). Ablating non-AF substrate with supraventricular tachycardia improved freedom from AF recurrence (P = .013). CONCLUSION: Recurrence of AF in the pediatric population is common, and the incidence of recurrence was not impacted by no treatment, medication only, or ablation treatment strategy. Ablation of pathways and other reentrant targets was the only intervention that decreased AF recurrence in children and young adults

SPHERE+, Imaging young planets down to the snow line

International audience<p>SPHERE, the high contrast imaging facility at the VLT has contributed significantly to the exploration of planetary systems, by revealing many details in proto-planetary and debris disks, by measuring the atmospheric properties of young giant planets and by deriving constraints on the giant planet population in long orbital periods. Such achievements allow us to provide a better understanding of planetary formation and evolution. The versatility of SPHERE also enables various secondary and sometimes unexpected science cases owing to a large spectral coverage from the visible to the near IR, and the availability of several observing modes as imaging, spectroscopy and polarimetry. Yet the access to the region where planets are expected to form, is not complete and still represents a challenge. To overcome this limitation larger contrasts at shorter separations are definitely required.<span class="Apple-converted-space"> </span></p> <p>The SPHERE+ concept precisely aims to provide the capabilities to primarily access the bulk of the young giant planet population down to the snowline<span class="Apple-converted-space">  </span>in order to bridge the gap with complementary techniques. As a second objective, SPHERE+ should be able to observe an increased sample of targets, fainter and redder than those observed in the first survey. Finally, SPHERE+ will provide a higher level of characterization of planet’s atmospheres. To achieve these goals, SPHERE should be upgraded with a faster Adaptive Optics system to reach<span class="Apple-converted-space">  </span>high contrasts at closer angular separations, together with a more sensitive wavefront sensor in the infrared to observe redder targets. Medium and high spectral resolution in the near infrared will be brought by a dedicated IFU spectrograph or taking advantage of the HiRISE project to combined SPHERE and CRIRES+. We will present the science cases and the technical solutions that are foreseen to reach the appropriate performances, and provide potential ways for such an upgrade. <span class="Apple-converted-space"> </span></p&gt