6,295 research outputs found
Resonant Inelastic X-Ray Scattering at the K Edge of Ge
We study the resonant inelastic x-ray scattering (RIXS) at the edge of
Ge. We measure RIXS spectra with systematically varying momenta in the final
state. The spectra are a measure of exciting an electron-hole pair. We find a
single peak structure (except the elastic peak) as a function of photon energy,
which is nearly independent of final-state momenta. We analyze the experimental
data by means of the band structure calculation. The calculation reproduces
well the experimental shape, clarifying the implication of the spectral shape.Comment: 17 pages,9 figures, Please also see our related paper:
cond-mat/040500
A bi-dimensional finite mixture model for longitudinal data subject to dropout
In longitudinal studies, subjects may be lost to follow-up, or miss some of
the planned visits, leading to incomplete response sequences. When the
probability of non-response, conditional on the available covariates and the
observed responses, still depends on unobserved outcomes, the dropout mechanism
is said to be non ignorable. A common objective is to build a reliable
association structure to account for dependence between the longitudinal and
the dropout processes. Starting from the existing literature, we introduce a
random coefficient based dropout model where the association between outcomes
is modeled through discrete latent effects. These effects are outcome-specific
and account for heterogeneity in the univariate profiles. Dependence between
profiles is introduced by using a bi-dimensional representation for the
corresponding distribution. In this way, we define a flexible latent class
structure which allows to efficiently describe both dependence within the two
margins of interest and dependence between them. By using this representation
we show that, unlike standard (unidimensional) finite mixture models, the non
ignorable dropout model properly nests its ignorable counterpart. We detail the
proposed modeling approach by analyzing data from a longitudinal study on the
dynamics of cognitive functioning in the elderly. Further, the effects of
assumptions about non ignorability of the dropout process on model parameter
estimates are (locally) investigated using the index of (local) sensitivity to
non-ignorability
What influences the speed of prototyping? An empirical investigation of twenty software startups
It is essential for startups to quickly experiment business ideas by building
tangible prototypes and collecting user feedback on them. As prototyping is an
inevitable part of learning for early stage software startups, how fast
startups can learn depends on how fast they can prototype. Despite of the
importance, there is a lack of research about prototyping in software startups.
In this study, we aimed at understanding what are factors influencing different
types of prototyping activities. We conducted a multiple case study on twenty
European software startups. The results are two folds, firstly we propose a
prototype-centric learning model in early stage software startups. Secondly, we
identify factors occur as barriers but also facilitators for prototyping in
early stage software startups. The factors are grouped into (1) artifacts, (2)
team competence, (3) collaboration, (4) customer and (5) process dimensions. To
speed up a startups progress at the early stage, it is important to incorporate
the learning objective into a well-defined collaborative approach of
prototypingComment: This is the author's version of the work. Copyright owner's version
can be accessed at doi.org/10.1007/978-3-319-57633-6_2, XP2017, Cologne,
German
Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever
There is a debate whether post-streptococcal reactive arthritis (PSRA) is a separate entity or a condition on the spectrum of acute rheumatic fever (ARF). We believe that PSRA is a distinct entity and in this paper we review the substantial differences between PSRA and ARF. We show how the demographic, clinical, genetic and treatment characteristics of PSRA differ from ARF. We review diagnostic criteria and regression formulas that attempt to classify patients with PSRA as opposed to ARF. The important implication of these findings may relate to the issue of prophylactic antibiotics after PSRA. However, future trials will be necessary to conclusively answer that question
Complex nature of SNP genotype effects on gene expression in primary human leucocytes.
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Genome wide association studies have been hugely successful in identifying disease risk variants, yet most variants do not lead to coding changes and how variants influence biological function is usually unknown. METHODS: We correlated gene expression and genetic variation in untouched primary leucocytes (n = 110) from individuals with celiac disease - a common condition with multiple risk variants identified. We compared our observations with an EBV-transformed HapMap B cell line dataset (n = 90), and performed a meta-analysis to increase power to detect non-tissue specific effects. RESULTS: In celiac peripheral blood, 2,315 SNP variants influenced gene expression at 765 different transcripts (< 250 kb from SNP, at FDR = 0.05, cis expression quantitative trait loci, eQTLs). 135 of the detected SNP-probe effects (reflecting 51 unique probes) were also detected in a HapMap B cell line published dataset, all with effects in the same allelic direction. Overall gene expression differences within the two datasets predominantly explain the limited overlap in observed cis-eQTLs. Celiac associated risk variants from two regions, containing genes IL18RAP and CCR3, showed significant cis genotype-expression correlations in the peripheral blood but not in the B cell line datasets. We identified 14 genes where a SNP affected the expression of different probes within the same gene, but in opposite allelic directions. By incorporating genetic variation in co-expression analyses, functional relationships between genes can be more significantly detected. CONCLUSION: In conclusion, the complex nature of genotypic effects in human populations makes the use of a relevant tissue, large datasets, and analysis of different exons essential to enable the identification of the function for many genetic risk variants in common diseases.Coeliac UKNetherlands Organization for Scientific ResearchCeliac Disease Consortium (an innovative cluster approved by the Netherlands Genomics Initiative and partly funded by the Dutch government)Netherlands Genomics InitiativeWellcome Trus
The 'not-so-strange' body in the mirror: : A principal components analysis of direct and mirror self-observation
This document is the Accepted Manuscript version of the following article: Paul M. Jenkinson, and Catherine Preston, âThe ânot-so-strangeâ body in the mirror: A principal components analysis of direct and mirror self-observationâ, Consciousness and Cognition, Vol. 48, pp. 262-272, first published online 4 January 2017, doi: http://dx.doi.org/10.1016/j.concog.2016.12.007 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.In this study we adopted a psychometric approach to examine how the body is subjectively experienced in a mirror. One hundred and twenty-four healthy participants viewed their body for five minutes directly or via a mirror, and then completed a 20-item questionnaire designed to capture subjective experiences of the body. PCA revealed a two-component structure for both direct and mirror conditions, comprising body evaluations (and alienation) and unusual feelings and perceptions. The relationship between these components and pre-existing tendencies for appearance anxiety, body dysmorphic-type beliefs, dissociative symptomatology, self-objectification and delusion ideation further supported the similarity between direct and mirror conditions; however, the occurrence of strange experiences like those reported to occur during prolonged face viewing was not confirmed. These results suggest that, despite obvious differences in visual feedback, observing the body via a mirror (as an outside observer) is subjectively equivalent to observing the body directly (from our own viewpoint).Peer reviewedFinal Accepted Versio
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