Double polarization hysteresis loop induced by the domain pinning by defect dipoles in HoMnO3 epitaxial thin films

We report on antiferroelectriclike double polarization hysteresis loops in multiferroic HoMnO3 thin films below the ferroelectric Curie temperature. This intriguing phenomenon is attributed to the domain pinning by defect dipoles which were introduced unintentionally during film growth process. Electron paramagnetic resonance suggests the existence of Fe1+ defects in thin films and first principles calculations reveal that the defect dipoles would be composed of oxygen vacancy and Fe1+ defect. We discuss migration of charged point defects during film growth process and formation of defect dipoles along ferroelectric polarization direction, based on the site preference of point defects. Due to a high-temperature low-symmetry structure of HoMnO3, aging is not required to form the defect dipoles in contrast to other ferroelectrics (e.g., BaTiO3).Comment: 4 figure

Production and optical properties of liquid scintillator for the JSNS2^{2} experiment

The JSNS$^{2}$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) experiment will search for neutrino oscillations over a 24 m short baseline at J-PARC. The JSNS$^{2}$ inner detector will be filled with 17 tons of gadolinium-loaded liquid scintillator (LS) with an additional 31 tons of unloaded LS in the intermediate $\gamma$-catcher and outer veto volumes. JSNS$^{2}$ has chosen Linear Alkyl Benzene (LAB) as an organic solvent because of its chemical properties. The unloaded LS was produced at a refurbished facility, originally used for scintillator production by the RENO experiment. JSNS$^{2}$ plans to use ISO tanks for the storage and transportation of the LS. In this paper, we describe the LS production, and present measurements of its optical properties and long term stability. Our measurements show that storing the LS in ISO tanks does not result in degradation of its optical properties.Comment: 7 pages, 4 figures

DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods

Increased appreciation of 5-hydroxymethylcytosine (5hmC) as a stable epigenetic mark, which defines cell identity and disease progress, has engendered a need for cost-effective, but high-resolution, 5hmC mapping technology. Current enrichment-based technologies provide cheap but low-resolution and relative enrichment of 5hmC levels, while single-base resolution methods can be prohibitively expensive to scale up to large experiments. To address this problem, we developed a deep learning-based method, DeepH&M, which integrates enrichment and restriction enzyme sequencing methods to simultaneously estimate absolute hydroxymethylation and methylation levels at single-CpG resolution. Using 7-week-old mouse cerebellum data for training the DeepH&M model, we demonstrated that the 5hmC and 5mC levels predicted by DeepH&M were in high concordance with whole-genome bisulfite-based approaches. The DeepH&M model can be applied to 7-week-old frontal cortex and 79-week-old cerebellum, revealing the robust generalizability of this method to other tissues from various biological time points

Magnetic field dependence of the neutron spin resonance in CeB6

In zero magnetic field, the famous neutron spin resonance in the f-electron superconductor CeCoIn5 is similar to the recently discovered exciton peak in the non-superconducting CeB6. Magnetic field splits the resonance in CeCoIn5 into two components, indicating that it is a doublet. Here we employ inelastic neutron scattering (INS) to scrutinize the field dependence of spin fluctuations in CeB6. The exciton shows a markedly different behavior without any field splitting. Instead, we observe a second field-induced magnon whose energy increases with field. At the ferromagnetic zone center, however, we find only a single mode with a non-monotonic field dependence. At low fields, it is initially suppressed to zero together with the antiferromagnetic order parameter, but then reappears at higher fields inside the hidden-order phase, following the energy of an electron spin resonance (ESR). This is a unique example of a ferromagnetic resonance in a heavy-fermion metal seen by both ESR and INS consistently over a broad range of magnetic fields.Comment: 7 pages, 6 figures including one animation, accepted to Phys. Rev.

CORRELATION BETWEEN LEUKOCYTE TELOMERE LENGTH AND DRUG ELUTING STENT STRUT COVERAGE BY OPTICAL COHERENCE TOMOGRAPHY

El cementiri de Sant Andreu fou inaugurat el 1839 i pertanyia a Sant Andreu del Palomar que formava part del Pla de Barcelona. Sembla que fou la primera població del Pla que va disposar de cementiri desprès de la construcció del de Poblenou

Constraints on the R-parity- and Lepton-Flavor-Violating Couplings from B0 Decats to Two Charged Leptons

We derive the upper bounds on certain products of R-parity- and lepton-flavor-violating couplings from the decays of the neutral $B$ meson into two charged leptons. These modes of $B^0$ decays can constrain the product combinations of the couplings with one or more heavy generation indices. We find that most of these bounds are stronger than the previous ones.Comment: Table is changed; version to appear in Phys. Rev.

Characterizing Glycemic Control and Sleep in Adults with Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness Initiating Hybrid Closed Loop Insulin Delivery

Nocturnal hypoglycemia is life threatening for individuals with type 1 diabetes (T1D) due to loss of hypoglycemia symptom recognition (hypoglycemia unawareness) and impaired glucose counter regulation. These individuals also show disturbed sleep, which may result from glycemic dysregulation. Whether use of a hybrid closed loop (HCL) insulin delivery system with integrated continuous glucose monitoring (CGM) designed for improving glycemic control, relates to better sleep across time in this population remains unknown. The purpose of this study was to describe long-term changes in glycemic control and objective sleep after initiating hybrid closed loop (HCL) insulin delivery in adults with type 1 diabetes and hypoglycemia unawareness. To accomplish this, six adults (median age = 58 y) participated in an 18-month ongoing trial assessing HCL effectiveness. Glycemic control and sleep were measured using continuous glucose monitoring and wrist accelerometers every 3 months. Paired sample t-tests and Cohen’s d effect sizes modeled glycemic and sleep changes and the magnitude of these changes from baseline to 9 months. Reduced hypoglycemia (d = 0:47‐0:79), reduced basal insulin requirements (d = 0:48), and a smaller glucose coefficient of variation (d = 0:47) occurred with medium-large effect sizes from baseline to 9 months. Hypoglycemia awareness improved from baseline to 6 months with medium-large effect sizes (Clarke score (d = 0:60), lability index (d = 0:50), HYPO score (d = 1:06)). Shorter sleep onset latency (d = 1:53; p \u3c 0:01), shorter sleep duration (d = 0:79), fewer total activity counts (d = 1:32), shorter average awakening length (d = 0:46), and delays in sleep onset (d = 1:06) and sleep midpoint (d = 0:72) occurred with medium-large effect sizes from baseline to 9 months. HCL led to clinically significant reductions in hypoglycemia and improved hypoglycemia awareness. Sleep showed a delayed onset, reduced awakening length and onset latency, and maintenance of high sleep efficiency after initiating HCL. Our findings add to the limited evidence on the relationships between diabetes therapeutic technologies and sleep health. This trial is registered with ClinicalTrials.gov (NCT03215914)