149 research outputs found

    The Future of Government: Lessons Learned from around the World

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    The report provides a summary of the discussions that have taken place within the framework of Forum activities on how the strategies, structures and practices of governments must change in the coming years, and how new networks and technologies can be leveraged to transform government capacity. It includes a series of policy briefs, which distils some of the most current and vital information for government modernization available, and concludes with case studies from around the world

    Are youth mentoring programs good value-for-money? An evaluation of the Big Brothers Big Sisters Melbourne Program

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    Background : The Big Brothers Big Sisters (BBBS) program matches vulnerable young people with a trained, supervised adult volunteer as mentor. The young people are typically seriously disadvantaged, with multiple psychosocial problems.Methods : Threshold analysis was undertaken to determine whether investment in the program was a worthwhile use of limited public funds. The potential cost savings were based on US estimates of life-time costs associated with high-risk youth who drop out-of-school and become adult criminals. The intervention was modelled for children aged 10&ndash;14 years residing in Melbourne in 2004.Results : If the program serviced 2,208 of the most vulnerable young people, it would cost AUD 39.5 M. Assuming 50% were high-risk, the associated costs of their adult criminality would be AUD 3.3 billion. To break even, the program would need to avert high-risk behaviours in only 1.3% (14/1,104) of participants.Conclusion : This indicative evaluation suggests that the BBBS program represents excellent \u27value for money\u27.<br /

    The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

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    The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

    The difficulties of Healthcare.gov need to be seen in the context of an acrimonious political climate and the poor record of large and complex IT projects

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    The past week has seen enormous criticism leveled at the rollout of the Affordable Care Act’s online enrollment platform, HealthCare.gov. Jane E. Fountain looks at the development of HealthCare.gov, and argues that the present delays and difficulties must be seen in the wider context of an incredibly complex system across public and private sectors, involving 55 contractors, five government agencies, 300 insurers and the integration of many new and old software components. With enrollments continuing, and the Obama administration’s attention focused on the problem, current critiques should be seen as making political theatre out of bumps in the road
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