Estimated cost of the building structure

Zadáno téma "Odhad nákladů stavebního objektu". Teoretická část je zaměřena na projektové řízení ve stavebnictví, náklady v projektech výstavby a realizační náklady. V praktické části je řešen odhad cen tří rodinných domů dle různých ukazatelů. V závěru práce je provedeno porovnání cen orientačních a cen získaných dle ukazatelů a porovnání indexů k roku 2005 v jednotlivých letech.Given subject "Estimated cost of the building structure". The theoretical part is focused on project management in construction, costs in construction projects and implementation costs. In the practical part is the estimate price of three houses according to various indicators. The present work is the comparison of indicative prices and prices received by indicators and indices compared to 2005 for each year.

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the question of feedback regulation of NOS activity and expression by its own product was raised. Since then, a number of trials have verified the existence of negative feedback loop both in vitro and in vivo. NO, whether released from exogenous donors or applied in authentic NO solution, is able to inhibit NOS activity and also intervenes in NOS expression processes by its effect on transcriptional nuclear factor NF-κB. The existence of negative feedback regulation of NOS may provide a powerful tool for experimental and clinical use, especially in inflammation, when massive NOS expression may be detrimental