100 let R. U. R.

Title in English: Hundred years of R. U. R.: Post-conference proceeding, Faculty of Education, Masaryk University, 11th September 2019. The publication is a post-conference proceeding marking the 100 years since Karel Čapek's first issuance of the science fiction play R. U. R. and the invention of the term robot by his brother Josef. The individual contributions within the proceeding are the result of an individual research of the conference participants. The published texts analyze the connotations of the term “robot” and reflect the social context of robotics, technology, and artificial intelligence. The reflection of the influence of visions from the work of Karel Čapek is also discussed. The papers possess a diverse character, the proceeding contains a philosophical essay, historical probes, philosophical analyzes and pedagogical applications of Čapek’s work and legacy

Desmoplastic Small Round Cell Tumor of the Uterus: A Report of Molecularly Confirmed Case with EWSR1-WT1 Fusion

We report a case of a 49-year-old female with desmoplastic small round cell tumor of the uterus (DSRCT). Histologically, in some areas the tumor showed typical features with ample desmoplastic stroma, while in other areas the tumor cells diffusely infiltrated myometrium with only focal desmoplastic reaction. Immunohistochemically, the tumor cells showed diffuse positivity for desmin, CD56, CD57, EMA and cyclin D1. Focal positivity was present for antibodies against cytokeratin AE1/3, BerEP4, NSE, IFITM1 and CD10. The WT-1 antibody (against the N-terminus) showed cytoplasmic positivity in some tumor cells, while the nuclei were negative. P53 expression was wild-type. The Ki-67 index (MIB1 antibody) was about 55%. Other markers examined including transgelin, myogenin, synaptophysin, chromogranin, h-caldesmon, PAX8, and CD117 were all negative. NGS analysis revealed a fusion transcript of the EWSR1 and WT1 genes. DSRCT of the uterus is a rare neoplasm, as only two cases have been reported so far. However, only one of these cases was examined molecularly with a confirmation of the characteristic EWSR1-WT1 fusion. We report a second case of molecularly confirmed DSRCT of the uterus and discuss its clinical features, differential diagnosis and the significance of molecular testing