SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE

The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed

Importance of Different Regions of H-2 for MLC Stimulation 1

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65829/1/j.1399-0039.1973.tb01008.x.pd

There are No Unfilled Shells in Hartree-Fock Theory

Hartree-Fock theory is supposed to yield a picture of atomic shells which may or may not be filled according to the atom's position in the periodic table. We prove that shells are always completely filled in an exact Hartree-Fock calculation. Our theorem generalizes to any system having a two-body interaction that, like the Coulomb potential, is repulsive.Comment: 5 pages, VBEHLMLJPS--16/July/9

Mixed lymphocyte culture reactivity and H-2 histocompatibility loci differences,

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34061/1/0000339.pd