Bayesian clinical trial designs : Another option for trauma trials?

The UK-REBOA Trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 14/199/09). PP was supported by the MRC Network of Hubs for Trials Methodology Research (MR/L004933/1-R/N/P/B1).Peer reviewedPublisher PD

A model for spatio-temporal injury surveillance : implications for the evolution of a trauma system

The authors thank the Scottish Ambulance Service for giving us access to the data for this study, and NHS Grampian Endowments for funding this research.Peer reviewedPostprin

Behavioural optimisation to address trial conduct challenges : case study in the UK-REBOA trial

Acknowledgements We thank the UK-REBOA site staf for dedicating their time to be interviewedPeer reviewedPublisher PD

The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage : study protocol for a randomised clinical trial (the UK-REBOA trial)

Acknowledgements The UK-REBOA trial grantholders include Jan O. Jansen, University of Aberdeen, UK, and University of Alabama at Birmingham, USA; Marion K. Campbell, University of Aberdeen, UK; Chris Moran, Nottingham University Hospital Trust, UK; Karim Brohi, Queen Mary University of London, UK; Fiona Lecky, University of Sheffield, UK; Robbie Lendrum, Bart’s Health NHS Trust, UK; Graeme MacLennan, University of Aberdeen, UK; Jonathan J. Morrison, University of Maryland, USA; Nigel Tai, Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, UK; Tim Harris, Bart’s Health NHS Trust, UK; John Norrie, University of Edinburgh, UK; Dwayne Boyers, University of Aberdeen, UK; Alan Paterson, University of Strathclyde, UK; and Nick Welch. Funding {4} This study/project is funded by the National Institute for Health Research (NIHR) HTA Programme (reference 14/199/09). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funder has/had no role in the design of the study; the collection, analysis, and interpretation of data; or writing the manuscript. The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates.Peer reviewedPublisher PD

Peripheral blood cytopenias in the aging general population and risk of incident hematological disease and mortality

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How the carrying capacity of the Wadden Sea regulates the number of wintering waders at Banc d’Arguin

Omdat veel van de in Afrika overwinterende steltlopers gebruik maken van de Waddenzee als opvetstation, zou de voedselsituatie in de Waddenzee wel eensvan invloed kunnen zijn op het aantal in Afrika overwinterende steltlopers. Om dit te onderzoeken wordt in dit artikel gekeken naar Kanoeten en hun voedsel, inde Wad denzee en op de Banc d’Arguin, vroeger en nu, daarbij gebruikmakend van de rigoureuze veranderingen die de laatste jaren in de Waddenzee hebben plaats gehad.The number of Red Knots Calidris canutus wintering at the Banc d'Arguin, Mauritania, has declined over the last two decades. The fact that food densities in this relatively undisturbed ecosystem have increased suggests that the reason for the declining Knot abundance needs to be sought elsewhere along the flyway. With the Wadden Sea acting as a major stopover site for Red Knots wintering at the Banc d'Arguin (at least in spring), we hypothesize that the declining food stocks in the Wadden Sea are responsible for the reduced number of Red Knots wintering in Mauritania. Speculating further, we bring up the idea that the declining Red Knot population has led to reduced predation pressure on the bivalve stocks at the Banc d'Arguin, which may be the reason why food densities in Mauritania have gone up. Others have brought up an alternative, but non-mutually exclusive, hypothesis explaining this increase by an increased algal production. With production rates in individual shellfish presumably being under strong density-dependent control, the reduced predation hypothesis (in contrast to the alternative hypothesis) predicts lower per capita shellfish production rates nowadays than two decades ago.</p