The UK-REBOA Trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 14/199/09). PP was supported by the MRC Network of Hubs for Trials Methodology Research (MR/L004933/1-R/N/P/B1).Peer reviewedPublisher PD

Campbell, Marion K.

Jansen, Jan O.

MacLennan, Graeme

Pallmann, Philip

UK-REBOA Trial Investigators

Journal of Trauma and Acute Care Surgery

English

Conducting clinical trials in trauma care is challenging. As new treatments become available, we are faced with the dilemma of how to confirm their effectiveness and strengthen the evidence base. Randomized controlled trials are the criterion standard, but target groups in trauma care are often small and specialized, making the classic approach to trial design difficult. Bayesian designs represent an innovative means of increasing trial efficiency and conducting trials with more realistic sample sizes. This article examines the design of such trials, using the UK-REBOA Trial as an example

Online Research @ Cardiff

Bayesian clinical trial designs: Another option for trauma trials?

The UK-REBOA Trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 14/199/09). PP was supported by the MRC Network of Hubs for Trials Methodology Research (MR/L004933/1-R/N/P/B1).Peer reviewe

The Open University

Bayesian clinical trial designs : Another option for trauma trials?

Jan O. Jansen

Philip Pallmann

Graeme MacLennan

Marion K. Campbell

Crossref

Bayesian clinical trial designs

https://aura.abdn.ac.uk/bitstream/2164/9434/1/Bayesian_clinical_trial_designs_Another_option.26_1_.pdf

Bayesian clinical trial designs : Another option for trauma trials?

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Online Research @ Cardiff

The Open University

Crossref