Developing Entrepreneurial Rural Communities

Rural communities in the United States have diversified and their dependence onagriculture has decreased substantially. In the 1980s, rural deindustrialization occurredand rural areas continued to become more service oriented: employment opportunitiesdeclined because of shifts in the world and U.S. economies, and anti-rural publicpolicies. In response, some rural communities have become entrepreneurial communities,whose characteristics include: healthy acceptance of controversy; a degree ofeconomic surplus to allow for risk-taking; willingness of community to tax itself tomaintain infrastructure and schools; the ability to define community broadly and tonetwork both vertically and horizontally to obtain resources; and dispersed communityleadership. Entrepreneurial behavior in the context of more favorable state and federalpolicies could help stabilize many rural communities

Field to Family Community Food Project

Community-supported agriculture (CSA) is a local food system in which farmers provide fresh food, fiber, and related products directly to the consumers in their area. The Field to Family Community Food Project began in 1997 and was intended to support the Magic Beanstalk CSA project by forming partnerships with other local organizations such as churches, social service organizations, Iowa State University, and other community groups

Toward a new Homestead Act: Designing a farmstead transfer and leasing program for high-value farming and farmstead preservation

Finding ways to make farming more accessible for would-be farmers involves working with existing landowners and potential tenants/buyers to educate both groups on the possibilities open to them. Surveys, focus groups and personal interviews were used to determine what tactics would be more effective in engaging both groups

Small Towns and Welfare Reform: Iowa Case Studies of Families and Communities

Since passage of the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) in 1996, public discussion of welfare reform and most research efforts to assess the effects of new policies have focused on urban areas. Major studies and frequent newspaper headlines have portrayed the dimensions of welfare reform in Los Angeles, Miami, Boston, and other urban settings (e.g., Burton et al. 1998; Quint et al. 1999). Little attention is being paid to the consequences of the new policies for rural families and communities.This book chapter is published as 2002 Fletcher, C. N., Flora, J. L., Gaddis, B. J., Winter, M., and J. S. Litt. “Small Towns and Welfare Reform: Iowa Case Studies of Families and Communities.” In Bruce A. Weber, Greg J. Duncan and Leslie A. Whitener (eds.) Rural Dimensions of Welfare Reform: Welfare, Food Assistance and Poverty in Rural America (pp. 201-229). Kalamazoo, MI: Upjohn Press. 10.17848/9781417508884 </p

Exploring the meanings of food and agriculture for Latino youth through the use of PhotoVoice in three Iowa cities

Presentation made at Latinos in the Heartland (11th : 2013 : Columbia, Mo.) and published in the annual conference proceedings.Using PhotoVoice as a tool for participatory action research, 10 Latino high school students, from three different cities of Iowa, Des Moines, Council Bluffs and Ottumwa, completed a project developed by Iowa State University Sociology Extension. The students explored the cultural meanings of food and agriculture within their families and in their communities. Participants were asked to reflect on and describe their pictures, incorporating their points of view on the different elements that integrated local food systems. We coded their final essays in NVIVO using the Community Capital Framework (CCF) to evaluate students' experiences and perceptions of food-value chains in their communities. The results showed cultural capital and bonding social capital to be the dominant themes, followed by health and nutrition (human capital) and natural capital (emphasis on home gardens and fresh vegetables). Financial capital, built and political capital indicators were mentioned incidentally to other capitals. Recommendations in this paper center on improving the use of PhotoVoice among Latino youth

Ubiquitin D regulates IRE1 α/c-Jun N-terminal kinase (JNK) protein-dependent apoptosis in pancreatic beta cells

Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes at least in part by inducing endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). It remains to be determined what causes the transition from "physiological" to "apoptotic" UPR, but accumulating evidence indicates that signaling by the ER transmembrane protein IRE1 alpha is critical for this transition. IRE1 alpha activation is regulated by both intra-ER and cytosolic cues. We evaluated the role for the presently discovered cytokine-induced and IRE1 alpha-interacting protein ubiquitin D (UBD) on the regulation of IRE1 alpha and its downstream targets. UBD was identified by use of a MAPPIT (mammalian protein-protein interaction trap)-based IRE1 alpha interactome screen followed by comparison against functional genomic analysis of human and rodent beta cells exposed to pro-inflammatory cytokines. Knockdown ofUBDin human and rodent beta cells and detailed signal transduction studies indicated that UBD modulates cytokine-induced UPR/IRE1 alpha activation and apoptosis. UBD expression is induced by the pro-inflammatory cytokines interleukin (IL)-1 beta and interferon (IFN)-gamma in rat and human pancreatic beta cells, and it is also up-regulated in beta cells of inflamed islets from non-obese diabetic mice. UBD interacts with IRE1 alpha in human and rodent beta cells, modulating IRE1 alpha-dependent activation of JNK and cytokine-induced apoptosis. Our data suggest that UBD provides a negative feedback on cytokine-induced activation of the IRE1 alpha/JNK pro-apoptotic pathway in cytokine-exposed beta cells

Community Health and Socioeconomic Issues Surrounding Concentrated Animal Feeding Operations

A consensus of the Workgroup on Community and Socioeconomic Issues was that improving and sustaining healthy rural communities depends on integrating socioeconomic development and environmental protection. The workgroup agreed that the World Health Organization’s definition of health, “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity,” applies to rural communities. These principles are embodied in the following main points agreed upon by this workgroup. Healthy rural communities ensure a) the physical and mental health of individuals, b) financial security for individuals and the greater community, c) social well-being, d ) social and environmental justice, and e) political equity and access. This workgroup evaluated impacts of the proliferation of concentrated animal feeding operations (CAFOs) on sustaining the health of rural communities. Recommended policy changes include a more stringent process for issuing permits for CAFOs, considering bonding for manure storage basins, limiting animal density per watershed, enhancing local control, and mandating environmental impact statements

Reproducibility of arterial spin labeling cerebral blood flow image processing:A report of the ISMRM open science initiative for perfusion imaging (OSIPI) and the ASL MRI challenge

Purpose: Arterial spin labeling (ASL) is a widely used contrast-free MRI method for assessing cerebral blood flow (CBF). Despite the generally adopted ASL acquisition guidelines, there is still wide variability in ASL analysis. We explored this variability through the ISMRM-OSIPI ASL-MRI Challenge, aiming to establish best practices for more reproducible ASL analysis. Methods: Eight teams analyzed the challenge data, which included a high-resolution T1-weighted anatomical image and 10 pseudo-continuous ASL datasets simulated using a digital reference object to generate ground-truth CBF values in normal and pathological states. We compared the accuracy of CBF quantification from each team's analysis to the ground truth across all voxels and within predefined brain regions. Reproducibility of CBF across analysis pipelines was assessed using the intra-class correlation coefficient (ICC), limits of agreement (LOA), and replicability of generating similar CBF estimates from different processing approaches. Results: Absolute errors in CBF estimates compared to ground-truth synthetic data ranged from 18.36 to 48.12 mL/100 g/min. Realistic motion incorporated into three datasets produced the largest absolute error and variability between teams, with the least agreement (ICC and LOA) with ground-truth results. Fifty percent of the submissions were replicated, and one produced three times larger CBF errors (46.59 mL/100 g/min) compared to submitted results. Conclusions: Variability in CBF measurements, influenced by differences in image processing, especially to compensate for motion, highlights the significance of standardizing ASL analysis workflows. We provide a recommendation for ASL processing based on top-performing approaches as a step toward ASL standardization.</p

Consensus guidelines for lumbar puncture in patients with neurological diseases

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate